SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u2x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 4u2x IMPORTIN SUBUNIT
ALPHA-6
(Homo
sapiens) 		3 / 3 TRP D 403
VAL D 363
TRP D 361
 None
 1.40A 1gmkC-4u2xD:
undetectable
1gmkD-4u2xD:
undetectable		 1gmkC-4u2xD:
8.13
1gmkD-4u2xD:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4u2x IMPORTIN SUBUNIT
ALPHA-6
(Homo
sapiens) 		5 / 10 LEU D 423
GLY D 424
LEU D 420
ILE D 405
PHE D 383
 None
 1.10A 2f8dA-4u2xD:
undetectable		 2f8dA-4u2xD:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 4u2x IMPORTIN SUBUNIT
ALPHA-6
(Homo
sapiens) 		3 / 3 LEU D 336
GLU D 358
ILE D 355
 None
 0.52A 3czhA-4u2xD:
undetectable		 3czhA-4u2xD:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 4u2x IMPORTIN SUBUNIT
ALPHA-6
(Homo
sapiens) 		5 / 12 LEU D 479
LEU D 445
LEU D 448
LEU D 452
LEU D 485
 None
 1.02A 3hm1A-4u2xD:
undetectable		 3hm1A-4u2xD:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4u2x IMPORTIN SUBUNIT
ALPHA-6
(Homo
sapiens) 		4 / 5 TYR D 504
ILE D 482
PRO D 468
THR D 409
 None
 1.27A 4ze1A-4u2xD:
undetectable		 4ze1A-4u2xD:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 4u2x IMPORTIN SUBUNIT
ALPHA-6
(Homo
sapiens) 		4 / 6 ARG D 398
ALA D 444
THR D 406
ALA D 401
 None
 1.03A 6ma6A-4u2xD:
undetectable		 6ma6A-4u2xD:
14.77