SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u33'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3001_1
(SERUM ALBUMIN)		 4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 11 PRO A 175
LEU A 176
LEU A 205
ARG A 134
ALA A 196
 None
 1.23A 1hk3A-4u33A:
2.2		 1hk3A-4u33A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 8 MET A 527
LEU A 523
ARG A 473
PRO A 495
 None
 1.10A 2qd2A-4u33A:
undetectable		 2qd2A-4u33A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 582
ILE A 579
ALA A 681
VAL A 626
MET A 516
 None
 1.10A 2qo4A-4u33A:
undetectable		 2qo4A-4u33A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 GLN A 510
THR A 501
TRP A 472
 None
 1.18A 2rctA-4u33A:
undetectable		 2rctA-4u33A:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 537
ALA A 267
ALA A 524
THR A 526
LEU A 582
 None
 1.19A 2x2nB-4u33A:
undetectable		 2x2nB-4u33A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 MET A 237
LEU A 343
PHE A 256
ALA A 334
ALA A 259
 None
 1.12A 3c6gB-4u33A:
undetectable		 3c6gB-4u33A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 MET A 237
PHE A 256
VAL A 331
ALA A 334
ALA A 259
 None
 1.11A 3dl9B-4u33A:
undetectable		 3dl9B-4u33A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 312
ASP A 326
PRO A 239
VAL A 341
LEU A 276
 None
 0.83A 3m6wA-4u33A:
undetectable		 3m6wA-4u33A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 9 PRO A 529
GLY A 232
ALA A 530
TRP A 234
LEU A 497
 None
 1.44A 3ur0C-4u33A:
undetectable		 3ur0C-4u33A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 172
LEU A 204
LEU A 205
ALA A 206
ARG A 134
 None
 1.10A 4fn9A-4u33A:
undetectable		 4fn9A-4u33A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 172
LEU A 204
LEU A 205
ALA A 206
ARG A 134
 None
 1.07A 4fn9B-4u33A:
undetectable		 4fn9B-4u33A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 263
LEU A 343
PHE A 327
PRO A 277
ASP A 326
 None
 1.46A 4j7xJ-4u33A:
undetectable		 4j7xJ-4u33A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 172
LEU A 204
LEU A 205
ALA A 206
ARG A 134
 None
 1.10A 4ltwA-4u33A:
undetectable		 4ltwA-4u33A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 8 MET A 269
ALA A 267
MET A 339
THR A 242
 None
 0.97A 4ltwA-4u33A:
undetectable		 4ltwA-4u33A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 240
HIS A 253
SER A 241
 None
 0.71A 4mjwA-4u33A:
undetectable
4mjwB-4u33A:
undetectable		 4mjwA-4u33A:
23.11
4mjwB-4u33A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 SER A 241
ARG A 240
HIS A 253
 None
 0.71A 4mjwA-4u33A:
undetectable
4mjwB-4u33A:
undetectable		 4mjwA-4u33A:
23.11
4mjwB-4u33A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 231
SER A 528
ALA A 530
LEU A 595
 None
 1.32A 5dzkg-4u33A:
2.8
5dzku-4u33A:
undetectable		 5dzkg-4u33A:
13.12
5dzku-4u33A:
1.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 330
LEU A 337
ALA A 334
TYR A 235
ILE A 266
 None
 1.42A 5ljbA-4u33A:
undetectable		 5ljbA-4u33A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 5 TYR A 691
ALA A 617
GLN A 110
THR A 112
 None
 1.36A 5n4iA-4u33A:
undetectable		 5n4iA-4u33A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 11 PRO A 495
PRO A 590
ALA A 591
PRO A 616
ALA A 617
 None
 1.19A 6bm5A-4u33A:
undetectable		 6bm5A-4u33A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 396
ASP A 392
GLN A 361
VAL A 317
 None
 1.14A 6bzoF-4u33A:
undetectable		 6bzoF-4u33A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 273
PHE A 414
PHE A 498
ASN A 496
VAL A 417
 None
 1.50A 6iblA-4u33A:
undetectable		 6iblA-4u33A:
20.36