SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u36'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		3 / 3 TRP A 155
VAL A 160
TRP A 153
 None
 1.30A 1c4dA-4u36A:
undetectable
1c4dB-4u36A:
undetectable		 1c4dA-4u36A:
5.47
1c4dB-4u36A:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		3 / 3 TRP A 153
VAL A 160
TRP A 155
 None
 1.34A 1c4dC-4u36A:
undetectable
1c4dD-4u36A:
undetectable		 1c4dC-4u36A:
5.47
1c4dD-4u36A:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		5 / 11 SER A 147
LEU A 107
GLY A 139
HIS A 221
GLU A 219
 MN  A 301 ( 4.2A)
None
None
None
None
 1.45A 1iolA-4u36A:
undetectable		 1iolA-4u36A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		5 / 12 GLY A 105
GLY A 139
GLU A 146
VAL A 189
ASP A 125
 TNR  A 303 (-3.2A)
None
None
None
CA  A 302 ( 2.1A)
 0.88A 2wa2B-4u36A:
undetectable		 2wa2B-4u36A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		3 / 3 SER A 128
THR A  85
PHE A  75
 CIT  A 308 (-4.5A)
CIT  A 308 (-4.8A)
None
 0.75A 2x91A-4u36A:
undetectable		 2x91A-4u36A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		3 / 3 TRP A 153
VAL A 160
TRP A 155
 None
 1.06A 2xdcC-4u36A:
undetectable
2xdcD-4u36A:
undetectable		 2xdcC-4u36A:
5.47
2xdcD-4u36A:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		3 / 3 TRP A 153
VAL A 160
TRP A 155
 None
 1.09A 2xdcE-4u36A:
undetectable
2xdcF-4u36A:
undetectable		 2xdcE-4u36A:
5.47
2xdcF-4u36A:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		3 / 3 TRP A 153
VAL A 160
TRP A 155
 None
 1.08A 2y5mE-4u36A:
undetectable
2y5mF-4u36A:
undetectable		 2y5mE-4u36A:
5.47
2y5mF-4u36A:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		3 / 3 TRP A 153
VAL A 160
TRP A 155
 None
 1.09A 2y6nC-4u36A:
undetectable
2y6nD-4u36A:
undetectable		 2y6nC-4u36A:
5.47
2y6nD-4u36A:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		3 / 3 TRP A 153
VAL A 160
TRP A 155
 None
 1.08A 2y6nE-4u36A:
undetectable
2y6nF-4u36A:
undetectable		 2y6nE-4u36A:
5.47
2y6nF-4u36A:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		3 / 3 PHE A 207
TYR A  52
LEU A  47
 None
 0.79A 3sueB-4u36A:
undetectable		 3sueB-4u36A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		5 / 12 PHE A  69
GLY A 206
ILE A  56
VAL A 203
ALA A  90
 None
 1.10A 4a6eA-4u36A:
undetectable		 4a6eA-4u36A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		4 / 7 ALA A  90
ALA A 176
GLY A 139
ILE A 138
 None
 0.68A 4eatA-4u36A:
undetectable		 4eatA-4u36A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		4 / 5 ALA A 121
ILE A 145
LEU A 107
ASN A 141
 None
 1.18A 4g19A-4u36A:
undetectable		 4g19A-4u36A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		5 / 12 LEU A  51
GLY A 206
VAL A 120
THR A  71
VAL A 163
 None
 1.33A 4okwA-4u36A:
undetectable		 4okwA-4u36A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		5 / 12 LEU A  51
GLY A 206
VAL A 120
THR A  71
VAL A 163
 None
 1.32A 4okxA-4u36A:
undetectable		 4okxA-4u36A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		4 / 8 ALA A 209
ILE A  18
GLY A 206
VAL A 163
 None
 0.85A 4r20A-4u36A:
undetectable		 4r20A-4u36A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		5 / 12 GLY A 105
GLY A 139
GLU A 146
VAL A 189
ASP A 125
 TNR  A 303 (-3.2A)
None
None
None
CA  A 302 ( 2.1A)
 0.84A 5njvD-4u36A:
undetectable		 5njvD-4u36A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		3 / 3 HIS A  57
GLU A 201
TRP A 202
 None
 1.19A 5odiD-4u36A:
undetectable		 5odiD-4u36A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		3 / 3 HIS A  57
GLU A 201
TRP A 202
 None
 1.15A 5odqD-4u36A:
undetectable		 5odqD-4u36A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		3 / 3 HIS A  57
GLU A 201
TRP A 202
 None
 1.17A 5odrD-4u36A:
undetectable		 5odrD-4u36A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		4 / 5 ASP A  87
PRO A  42
GLU A  78
THR A 220
 TNR  A 303 (-2.7A)
None
None
None
 1.37A 5uxcA-4u36A:
undetectable		 5uxcA-4u36A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		5 / 12 GLY A 105
GLY A 139
GLU A 146
VAL A 189
ASP A 125
 TNR  A 303 (-3.2A)
None
None
None
CA  A 302 ( 2.1A)
 0.98A 5wz1C-4u36A:
undetectable		 5wz1C-4u36A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		5 / 12 GLY A 105
GLY A 139
GLU A 146
VAL A 189
ASP A 125
 TNR  A 303 (-3.2A)
None
None
None
CA  A 302 ( 2.1A)
 0.98A 5wz1D-4u36A:
undetectable		 5wz1D-4u36A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		5 / 12 GLY A 105
GLY A 139
GLU A 146
VAL A 189
ASP A 125
 TNR  A 303 (-3.2A)
None
None
None
CA  A 302 ( 2.1A)
 0.94A 5wz1E-4u36A:
undetectable		 5wz1E-4u36A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		5 / 12 GLY A 105
GLY A 139
GLU A 146
VAL A 189
ASP A 125
 TNR  A 303 (-3.2A)
None
None
None
CA  A 302 ( 2.1A)
 0.98A 5wz1F-4u36A:
undetectable		 5wz1F-4u36A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		5 / 12 GLY A 105
GLY A 139
GLU A 146
VAL A 189
ASP A 125
 TNR  A 303 (-3.2A)
None
None
None
CA  A 302 ( 2.1A)
 0.99A 5wz1G-4u36A:
undetectable		 5wz1G-4u36A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		5 / 12 GLY A 105
GLY A 139
GLU A 146
VAL A 189
ASP A 125
 TNR  A 303 (-3.2A)
None
None
None
CA  A 302 ( 2.1A)
 0.96A 5wz1H-4u36A:
undetectable		 5wz1H-4u36A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		3 / 3 ARG A 136
LYS A 152
TYR A 187
 CIT  A 308 (-4.0A)
None
None
 1.28A 6gnaA-4u36A:
undetectable		 6gnaA-4u36A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4u36 SEED LECTIN
(Vatairea
macrocarpa) 		3 / 3 ARG A 136
LYS A 152
TYR A 187
 CIT  A 308 (-4.0A)
None
None
 1.28A 6gnbA-4u36A:
undetectable		 6gnbA-4u36A:
18.73