SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u3a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ARG A 124
VAL A 317
TRP A 347
 None
 1.03A 1qw6A-4u3aA:
undetectable		 1qw6A-4u3aA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ARG A 124
VAL A 317
TRP A 347
 None
 1.05A 1qwcA-4u3aA:
0.5		 1qwcA-4u3aA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ARG A 124
VAL A 317
TRP A 347
 None
 1.08A 1vagA-4u3aA:
undetectable		 1vagA-4u3aA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		3 / 3 TRP A 155
LEU A 157
LYS A 198
 None
 1.21A 1yajK-4u3aA:
undetectable		 1yajK-4u3aA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ARG A 124
VAL A 317
TRP A 347
 None
 1.03A 1zviA-4u3aA:
undetectable		 1zviA-4u3aA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		5 / 12 PHE A 115
VAL A 123
ILE A 125
GLU A  96
ALA A 360
 None
 1.34A 3apwA-4u3aA:
undetectable		 3apwA-4u3aA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		4 / 5 VAL A 239
THR A 163
THR A 236
ARG A 231
 None
 1.21A 3bjwG-4u3aA:
undetectable		 3bjwG-4u3aA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		4 / 5 VAL A 239
THR A 163
THR A 236
ARG A 231
 None
 1.09A 3bjwD-4u3aA:
undetectable		 3bjwD-4u3aA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		5 / 10 VAL A 153
ASP A 154
LEU A 203
PHE A 204
THR A 236
 None
 1.20A 3j6gB-4u3aA:
undetectable		 3j6gB-4u3aA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		5 / 10 VAL A 153
ASP A 154
LEU A 203
PHE A 204
THR A 236
 None
 1.19A 3j6gD-4u3aA:
2.6		 3j6gD-4u3aA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		5 / 10 VAL A 153
ASP A 154
LEU A 203
PHE A 204
THR A 236
 None
 1.20A 3j6gF-4u3aA:
undetectable		 3j6gF-4u3aA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		5 / 10 VAL A 153
ASP A 154
LEU A 203
PHE A 204
THR A 236
 None
 1.20A 3j6gH-4u3aA:
undetectable		 3j6gH-4u3aA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		5 / 10 VAL A 153
ASP A 154
LEU A 203
PHE A 204
THR A 236
 None
 1.20A 3j6gJ-4u3aA:
undetectable		 3j6gJ-4u3aA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		5 / 10 VAL A 153
ASP A 154
LEU A 203
PHE A 204
THR A 236
 None
 1.20A 3j6gL-4u3aA:
undetectable		 3j6gL-4u3aA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		5 / 10 VAL A 153
ASP A 154
LEU A 203
PHE A 204
THR A 236
 None
 1.20A 3j6gN-4u3aA:
undetectable		 3j6gN-4u3aA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		5 / 10 VAL A 153
ASP A 154
LEU A 203
PHE A 204
THR A 236
 None
 1.20A 3j6gP-4u3aA:
undetectable		 3j6gP-4u3aA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		5 / 10 VAL A 153
ASP A 154
LEU A 203
PHE A 204
THR A 236
 None
 1.20A 3j6gR-4u3aA:
undetectable		 3j6gR-4u3aA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ARG A 340
ASP A 304
ASP A 297
 None
 0.89A 3jayA-4u3aA:
undetectable		 3jayA-4u3aA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		4 / 8 PRO A 210
HIS A 168
ILE A 240
ARG A 124
 None
 0.94A 3sfeB-4u3aA:
undetectable
3sfeC-4u3aA:
undetectable		 3sfeB-4u3aA:
19.42
3sfeC-4u3aA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A 191
TRP A 129
VAL A 127
LEU A  91
PHE A 115
 None
 1.15A 3w67C-4u3aA:
undetectable		 3w67C-4u3aA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A 191
TRP A 129
VAL A 127
LEU A  91
PHE A 115
 None
 1.20A 3w68C-4u3aA:
2.7		 3w68C-4u3aA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		4 / 5 TYR A 120
LEU A 338
ASP A 331
VAL A 292
 None
 1.32A 4nkvA-4u3aA:
undetectable		 4nkvA-4u3aA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		4 / 5 TYR A 139
ARG A 183
ASP A 170
GLU A 185
 None
 1.33A 4nkvB-4u3aA:
undetectable		 4nkvB-4u3aA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 350
ASP A 370
ILE A 361
VAL A 346
ARG A 326
 None
 1.18A 4u8vB-4u3aA:
undetectable		 4u8vB-4u3aA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ASP A 297
SER A 301
ARG A 340
TRP A 302
 None
 0.86A 4uhxA-4u3aA:
undetectable		 4uhxA-4u3aA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ASP A 297
SER A 301
ARG A 340
TRP A 302
 None
 0.86A 4uhxA-4u3aA:
undetectable		 4uhxA-4u3aA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		4 / 7 THR A 140
TYR A 139
PRO A 138
THR A 136
 None
 1.27A 5b6iA-4u3aA:
undetectable		 5b6iA-4u3aA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		5 / 9 VAL A 153
VAL A 149
ILE A 191
PHE A 204
LEU A 202
 None
 1.35A 5e4dA-4u3aA:
undetectable		 5e4dA-4u3aA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ARG A 124
VAL A 317
TRP A 347
 None
 1.03A 5fvoA-4u3aA:
undetectable		 5fvoA-4u3aA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4u3a ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		5 / 12 VAL A 153
ASP A 154
LEU A 203
PHE A 204
THR A 236
 None
 1.33A 5hnxB-4u3aA:
undetectable		 5hnxB-4u3aA:
19.79