SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u3j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4u3j PROTEIN STU2
(Saccharomyces
cerevisiae) 		5 / 10 PHE C 526
GLY C 522
ASN C 482
VAL C 504
PHE C 538
 None
 1.26A 3ay0B-4u3jC:
undetectable		 3ay0B-4u3jC:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4u3j PROTEIN STU2
(Saccharomyces
cerevisiae) 		3 / 3 ALA C 517
ARG C 519
LYS C 549
 None
 1.01A 3kp3B-4u3jC:
undetectable		 3kp3B-4u3jC:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4u3j PROTEIN STU2
(Saccharomyces
cerevisiae) 		3 / 3 ALA C 517
ARG C 519
LYS C 549
 None
 0.97A 3kp5B-4u3jC:
undetectable		 3kp5B-4u3jC:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 4u3j PROTEIN STU2
(Saccharomyces
cerevisiae) 		5 / 11 ASP C 447
LEU C 449
THR C 494
GLY C 491
ASP C 490
 None
 1.44A 3sfuC-4u3jC:
undetectable		 3sfuC-4u3jC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 4u3j PROTEIN STU2
(Saccharomyces
cerevisiae) 		4 / 5 SER C 493
GLU C 488
THR C 494
ASP C 447
 None
 1.39A 3zs3A-4u3jC:
undetectable		 3zs3A-4u3jC:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CUT_A_TYLA2971_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 4u3j PROTEIN STU2
(Saccharomyces
cerevisiae) 		4 / 4 VAL C 507
VAL C 503
ASN C 482
ILE C 528
 None
 1.47A 4cutA-4u3jC:
undetectable		 4cutA-4u3jC:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 4u3j PROTEIN STU2
(Saccharomyces
cerevisiae) 		4 / 8 TYR C 369
ASP C 326
VAL C 355
LEU C 362
 None
 1.01A 4f8hA-4u3jC:
2.5
4f8hB-4u3jC:
2.5		 4f8hA-4u3jC:
21.19
4f8hB-4u3jC:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 4u3j PROTEIN STU2
(Saccharomyces
cerevisiae) 		4 / 8 TYR C 369
ASP C 326
VAL C 355
LEU C 362
 None
 1.05A 4f8hC-4u3jC:
2.5
4f8hD-4u3jC:
2.6		 4f8hC-4u3jC:
21.19
4f8hD-4u3jC:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 4u3j PROTEIN STU2
(Saccharomyces
cerevisiae) 		4 / 8 TYR C 369
ASP C 326
VAL C 355
LEU C 362
 None
 1.03A 4f8hD-4u3jC:
2.6
4f8hE-4u3jC:
2.5		 4f8hD-4u3jC:
21.19
4f8hE-4u3jC:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 4u3j PROTEIN STU2
(Saccharomyces
cerevisiae) 		4 / 8 VAL C 355
LEU C 362
TYR C 369
ASP C 326
 None
 1.07A 4f8hA-4u3jC:
2.5
4f8hE-4u3jC:
2.5		 4f8hA-4u3jC:
21.19
4f8hE-4u3jC:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 4u3j PROTEIN STU2
(Saccharomyces
cerevisiae) 		3 / 3 ASN C 455
SER C 452
SER C 451
 None
 0.78A 5gsnA-4u3jC:
undetectable		 5gsnA-4u3jC:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 4u3j PROTEIN STU2
(Saccharomyces
cerevisiae) 		5 / 12 GLU C 487
LEU C 495
GLY C 491
PHE C 417
ILE C 462
 None
 1.34A 5tuiB-4u3jC:
undetectable		 5tuiB-4u3jC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 4u3j PROTEIN STU2
(Saccharomyces
cerevisiae) 		5 / 12 GLY C 522
SER C 525
GLU C 524
LEU C 529
PHE C 523
 None
 1.36A 5vlmF-4u3jC:
1.8		 5vlmF-4u3jC:
21.40