SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u3v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1V_A_H4BA700_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.04A 1d1vA-4u3vA:
undetectable
1d1vB-4u3vA:
undetectable		 1d1vA-4u3vA:
19.43
1d1vB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1V_B_H4BB701_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.07A 1d1vA-4u3vA:
undetectable
1d1vB-4u3vA:
undetectable		 1d1vA-4u3vA:
19.43
1d1vB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1W_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.05A 1d1wA-4u3vA:
undetectable
1d1wB-4u3vA:
undetectable		 1d1wA-4u3vA:
19.43
1d1wB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1W_B_H4BB601_1
(NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.09A 1d1wA-4u3vA:
undetectable
1d1wB-4u3vA:
undetectable		 1d1wA-4u3vA:
19.43
1d1wB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1X_A_H4BA600_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME DOMAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.06A 1d1xA-4u3vA:
undetectable
1d1xB-4u3vA:
undetectable		 1d1xA-4u3vA:
19.43
1d1xB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1X_B_H4BB601_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME DOMAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.08A 1d1xA-4u3vA:
undetectable
1d1xB-4u3vA:
undetectable		 1d1xA-4u3vA:
19.43
1d1xB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DM8_A_H4BA1600_1
(NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.04A 1dm8A-4u3vA:
undetectable
1dm8B-4u3vA:
undetectable		 1dm8A-4u3vA:
19.43
1dm8B-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DM8_B_H4BB2600_1
(NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.09A 1dm8A-4u3vA:
undetectable
1dm8B-4u3vA:
undetectable		 1dm8A-4u3vA:
19.43
1dm8B-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 8 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.11A 1dmiA-4u3vA:
undetectable
1dmiB-4u3vA:
undetectable		 1dmiA-4u3vA:
19.43
1dmiB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_B_BHSB2610_1
(NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.13A 1dmiA-4u3vA:
undetectable
1dmiB-4u3vA:
undetectable		 1dmiA-4u3vA:
19.43
1dmiB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOP_A_H4BA1600_1
(NITRIC-OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.06A 1fopA-4u3vA:
undetectable
1fopB-4u3vA:
undetectable		 1fopA-4u3vA:
19.43
1fopB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOP_B_H4BB2600_1
(NITRIC-OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.10A 1fopA-4u3vA:
undetectable
1fopB-4u3vA:
undetectable		 1fopA-4u3vA:
19.43
1fopB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSE_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.02A 1nseA-4u3vA:
undetectable
1nseB-4u3vA:
undetectable		 1nseA-4u3vA:
19.43
1nseB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSE_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 1nseA-4u3vA:
undetectable
1nseB-4u3vA:
undetectable		 1nseA-4u3vA:
19.43
1nseB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6L_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.10A 1p6lA-4u3vA:
undetectable
1p6lB-4u3vA:
undetectable		 1p6lA-4u3vA:
20.05
1p6lB-4u3vA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6L_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.08A 1p6lA-4u3vA:
undetectable
1p6lB-4u3vA:
undetectable		 1p6lA-4u3vA:
20.05
1p6lB-4u3vA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6M_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.07A 1p6mA-4u3vA:
undetectable
1p6mB-4u3vA:
undetectable		 1p6mA-4u3vA:
20.05
1p6mB-4u3vA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6M_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 1p6mA-4u3vA:
undetectable
1p6mB-4u3vA:
undetectable		 1p6mA-4u3vA:
20.05
1p6mB-4u3vA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6N_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.10A 1p6nA-4u3vA:
undetectable
1p6nB-4u3vA:
undetectable		 1p6nA-4u3vA:
20.05
1p6nB-4u3vA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6N_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.07A 1p6nA-4u3vA:
undetectable
1p6nB-4u3vA:
undetectable		 1p6nA-4u3vA:
20.05
1p6nB-4u3vA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q2O_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.05A 1q2oA-4u3vA:
undetectable
1q2oB-4u3vA:
undetectable		 1q2oA-4u3vA:
20.24
1q2oB-4u3vA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q2O_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.07A 1q2oA-4u3vA:
undetectable
1q2oB-4u3vA:
undetectable		 1q2oA-4u3vA:
20.24
1q2oB-4u3vA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS8_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.08A 1rs8A-4u3vA:
undetectable
1rs8B-4u3vA:
undetectable		 1rs8A-4u3vA:
20.24
1rs8B-4u3vA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS8_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.05A 1rs8A-4u3vA:
undetectable
1rs8B-4u3vA:
undetectable		 1rs8A-4u3vA:
20.24
1rs8B-4u3vA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS9_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.02A 1rs9A-4u3vA:
undetectable
1rs9B-4u3vA:
undetectable		 1rs9A-4u3vA:
20.24
1rs9B-4u3vA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS9_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.03A 1rs9A-4u3vA:
undetectable
1rs9B-4u3vA:
undetectable		 1rs9A-4u3vA:
20.24
1rs9B-4u3vA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 8 THR A 146
CYH A 220
LEU A 222
MET A 180
 None
 1.37A 1uw6A-4u3vA:
undetectable
1uw6B-4u3vA:
undetectable		 1uw6A-4u3vA:
20.20
1uw6B-4u3vA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 8 THR A 146
CYH A 220
LEU A 222
MET A 180
 None
 1.32A 1uw6D-4u3vA:
undetectable
1uw6E-4u3vA:
undetectable		 1uw6D-4u3vA:
20.20
1uw6E-4u3vA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 8 THR A 146
CYH A 220
LEU A 222
MET A 180
 None
 1.32A 1uw6G-4u3vA:
undetectable
1uw6H-4u3vA:
undetectable		 1uw6G-4u3vA:
20.20
1uw6H-4u3vA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 8 THR A 146
CYH A 220
LEU A 222
MET A 180
 None
 1.35A 1uw6P-4u3vA:
undetectable
1uw6Q-4u3vA:
undetectable		 1uw6P-4u3vA:
20.20
1uw6Q-4u3vA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 8 THR A 215
CYH A 220
LEU A 163
MET A 180
 None
 1.26A 1uw6P-4u3vA:
undetectable
1uw6Q-4u3vA:
undetectable		 1uw6P-4u3vA:
20.20
1uw6Q-4u3vA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 8 LEU A 163
MET A 180
THR A 215
CYH A 220
 None
 1.27A 1uw6P-4u3vA:
undetectable
1uw6T-4u3vA:
undetectable		 1uw6P-4u3vA:
20.20
1uw6T-4u3vA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 8 LEU A 222
MET A 180
THR A 146
CYH A 220
 None
 1.38A 1uw6P-4u3vA:
undetectable
1uw6T-4u3vA:
undetectable		 1uw6P-4u3vA:
20.20
1uw6T-4u3vA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		5 / 12 TYR A 185
THR A 181
PRO A 203
VAL A 240
LEU A 249
 None
 1.39A 1z9hB-4u3vA:
undetectable		 1z9hB-4u3vA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.01A 1zzrA-4u3vA:
undetectable
1zzrB-4u3vA:
undetectable		 1zzrA-4u3vA:
20.91
1zzrB-4u3vA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.02A 1zzrA-4u3vA:
undetectable
1zzrB-4u3vA:
undetectable		 1zzrA-4u3vA:
20.91
1zzrB-4u3vA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZS_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.05A 1zzsA-4u3vA:
undetectable
1zzsB-4u3vA:
undetectable		 1zzsA-4u3vA:
20.24
1zzsB-4u3vA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZS_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 1zzsA-4u3vA:
undetectable
1zzsB-4u3vA:
undetectable		 1zzsA-4u3vA:
20.24
1zzsB-4u3vA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.01A 1zzuA-4u3vA:
undetectable
1zzuB-4u3vA:
undetectable		 1zzuA-4u3vA:
20.91
1zzuB-4u3vA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.02A 1zzuA-4u3vA:
undetectable
1zzuB-4u3vA:
undetectable		 1zzuA-4u3vA:
20.91
1zzuB-4u3vA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX2_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 2hx2A-4u3vA:
undetectable
2hx2B-4u3vA:
undetectable		 2hx2A-4u3vA:
20.24
2hx2B-4u3vA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX2_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.05A 2hx2A-4u3vA:
undetectable
2hx2B-4u3vA:
undetectable		 2hx2A-4u3vA:
20.24
2hx2B-4u3vA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSE_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 2nseA-4u3vA:
undetectable
2nseB-4u3vA:
undetectable		 2nseA-4u3vA:
19.43
2nseB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 8 LEU A 222
LEU A 163
LYS A 217
LEU A 249
 None
 1.03A 2xn3A-4u3vA:
undetectable
2xn3B-4u3vA:
undetectable		 2xn3A-4u3vA:
22.87
2xn3B-4u3vA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 0.97A 3dqrA-4u3vA:
undetectable
3dqrB-4u3vA:
undetectable		 3dqrA-4u3vA:
20.81
3dqrB-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.03A 3dqrA-4u3vA:
undetectable
3dqrB-4u3vA:
undetectable		 3dqrA-4u3vA:
20.81
3dqrB-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 3dqsA-4u3vA:
undetectable
3dqsB-4u3vA:
undetectable		 3dqsA-4u3vA:
20.24
3dqsB-4u3vA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQS_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.07A 3dqsA-4u3vA:
undetectable
3dqsB-4u3vA:
undetectable		 3dqsA-4u3vA:
20.24
3dqsB-4u3vA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.06A 3dqtA-4u3vA:
undetectable
3dqtB-4u3vA:
undetectable		 3dqtA-4u3vA:
20.24
3dqtB-4u3vA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.08A 3dqtA-4u3vA:
undetectable
3dqtB-4u3vA:
undetectable		 3dqtA-4u3vA:
20.24
3dqtB-4u3vA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWX_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.06A 3jwxA-4u3vA:
undetectable
3jwxB-4u3vA:
undetectable		 3jwxA-4u3vA:
19.43
3jwxB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.04A 3jwxA-4u3vA:
undetectable
3jwxB-4u3vA:
undetectable		 3jwxA-4u3vA:
19.43
3jwxB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.01A 3jwyA-4u3vA:
undetectable
3jwyB-4u3vA:
undetectable		 3jwyA-4u3vA:
19.43
3jwyB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.02A 3jwyA-4u3vA:
undetectable
3jwyB-4u3vA:
undetectable		 3jwyA-4u3vA:
19.43
3jwyB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.02A 3jwzA-4u3vA:
undetectable
3jwzB-4u3vA:
undetectable		 3jwzA-4u3vA:
19.43
3jwzB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWZ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.04A 3jwzA-4u3vA:
undetectable
3jwzB-4u3vA:
undetectable		 3jwzA-4u3vA:
19.43
3jwzB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.00A 3jx2A-4u3vA:
undetectable
3jx2B-4u3vA:
undetectable		 3jx2A-4u3vA:
20.81
3jx2B-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.01A 3jx2A-4u3vA:
undetectable
3jx2B-4u3vA:
undetectable		 3jx2A-4u3vA:
20.81
3jx2B-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 3jx3A-4u3vA:
undetectable
3jx3B-4u3vA:
undetectable		 3jx3A-4u3vA:
20.81
3jx3B-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.03A 3jx3A-4u3vA:
undetectable
3jx3B-4u3vA:
undetectable		 3jx3A-4u3vA:
20.81
3jx3B-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.02A 3jx4A-4u3vA:
undetectable
3jx4B-4u3vA:
undetectable		 3jx4A-4u3vA:
20.81
3jx4B-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 3jx5A-4u3vA:
undetectable
3jx5B-4u3vA:
undetectable		 3jx5A-4u3vA:
20.81
3jx5B-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.03A 3jx5A-4u3vA:
undetectable
3jx5B-4u3vA:
undetectable		 3jx5A-4u3vA:
20.81
3jx5B-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.05A 3jx6A-4u3vA:
undetectable
3jx6B-4u3vA:
undetectable		 3jx6A-4u3vA:
20.81
3jx6B-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 3jx6A-4u3vA:
undetectable
3jx6B-4u3vA:
undetectable		 3jx6A-4u3vA:
20.81
3jx6B-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5P_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 0.99A 3n5pA-4u3vA:
undetectable
3n5pB-4u3vA:
undetectable		 3n5pA-4u3vA:
19.43
3n5pB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Q_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.02A 3n5qA-4u3vA:
undetectable
3n5qB-4u3vA:
undetectable		 3n5qA-4u3vA:
19.43
3n5qB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5R_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 3n5rA-4u3vA:
undetectable
3n5rB-4u3vA:
undetectable		 3n5rA-4u3vA:
19.43
3n5rB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5R_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.03A 3n5rA-4u3vA:
undetectable
3n5rB-4u3vA:
undetectable		 3n5rA-4u3vA:
19.43
3n5rB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5S_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 3n5sA-4u3vA:
undetectable
3n5sB-4u3vA:
undetectable		 3n5sA-4u3vA:
19.43
3n5sB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5S_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.05A 3n5sA-4u3vA:
undetectable
3n5sB-4u3vA:
undetectable		 3n5sA-4u3vA:
19.43
3n5sB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.06A 3n5tA-4u3vA:
undetectable
3n5tB-4u3vA:
undetectable		 3n5tA-4u3vA:
19.43
3n5tB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.09A 3n5tA-4u3vA:
undetectable
3n5tB-4u3vA:
undetectable		 3n5tA-4u3vA:
19.43
3n5tB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.04A 3n61A-4u3vA:
undetectable
3n61B-4u3vA:
undetectable		 3n61A-4u3vA:
20.81
3n61B-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 3n61A-4u3vA:
undetectable
3n61B-4u3vA:
undetectable		 3n61A-4u3vA:
20.81
3n61B-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6E_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 3n6eA-4u3vA:
undetectable
3n6eB-4u3vA:
undetectable		 3n6eA-4u3vA:
19.43
3n6eB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6E_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.07A 3n6eA-4u3vA:
undetectable
3n6eB-4u3vA:
undetectable		 3n6eA-4u3vA:
19.43
3n6eB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6F_A_H4BA600_1
('NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.02A 3n6fA-4u3vA:
undetectable
3n6fB-4u3vA:
undetectable		 3n6fA-4u3vA:
19.43
3n6fB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6F_B_H4BB600_1
('NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.02A 3n6fA-4u3vA:
undetectable
3n6fB-4u3vA:
undetectable		 3n6fA-4u3vA:
19.43
3n6fB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6G_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.05A 3n6gA-4u3vA:
undetectable
3n6gB-4u3vA:
undetectable		 3n6gA-4u3vA:
19.43
3n6gB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6G_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.04A 3n6gA-4u3vA:
undetectable
3n6gB-4u3vA:
undetectable		 3n6gA-4u3vA:
19.43
3n6gB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLD_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.04A 3nldA-4u3vA:
undetectable
3nldB-4u3vA:
undetectable		 3nldA-4u3vA:
19.43
3nldB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLE_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.07A 3nleA-4u3vA:
undetectable
3nleB-4u3vA:
undetectable		 3nleA-4u3vA:
19.43
3nleB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLE_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 3nleA-4u3vA:
undetectable
3nleB-4u3vA:
undetectable		 3nleA-4u3vA:
19.43
3nleB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLF_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.01A 3nlfA-4u3vA:
undetectable
3nlfB-4u3vA:
undetectable		 3nlfA-4u3vA:
19.43
3nlfB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLG_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.04A 3nlgA-4u3vA:
undetectable
3nlgB-4u3vA:
undetectable		 3nlgA-4u3vA:
19.43
3nlgB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLG_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.07A 3nlgA-4u3vA:
undetectable
3nlgB-4u3vA:
undetectable		 3nlgA-4u3vA:
19.43
3nlgB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLH_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.04A 3nlhA-4u3vA:
undetectable
3nlhB-4u3vA:
undetectable		 3nlhA-4u3vA:
19.43
3nlhB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLH_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 3nlhA-4u3vA:
undetectable
3nlhB-4u3vA:
undetectable		 3nlhA-4u3vA:
19.43
3nlhB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLI_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.05A 3nliA-4u3vA:
undetectable
3nliB-4u3vA:
undetectable		 3nliA-4u3vA:
19.43
3nliB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLI_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 3nliA-4u3vA:
undetectable
3nliB-4u3vA:
undetectable		 3nliA-4u3vA:
19.43
3nliB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 3nljA-4u3vA:
undetectable
3nljB-4u3vA:
undetectable		 3nljA-4u3vA:
20.81
3nljB-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.04A 3nljA-4u3vA:
undetectable
3nljB-4u3vA:
undetectable		 3nljA-4u3vA:
20.81
3nljB-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.02A 3nlpA-4u3vA:
undetectable
3nlpB-4u3vA:
undetectable		 3nlpA-4u3vA:
20.81
3nlpB-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.02A 3nlpA-4u3vA:
undetectable
3nlpB-4u3vA:
undetectable		 3nlpA-4u3vA:
20.81
3nlpB-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 8 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.05A 3nlqA-4u3vA:
undetectable
3nlqB-4u3vA:
undetectable		 3nlqA-4u3vA:
20.81
3nlqB-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.04A 3nlqA-4u3vA:
undetectable
3nlqB-4u3vA:
undetectable		 3nlqA-4u3vA:
20.81
3nlqB-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.00A 3nlrA-4u3vA:
undetectable
3nlrB-4u3vA:
undetectable		 3nlrA-4u3vA:
20.81
3nlrB-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 8 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.00A 3nlrA-4u3vA:
undetectable
3nlrB-4u3vA:
undetectable		 3nlrA-4u3vA:
20.81
3nlrB-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLU_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.05A 3nluA-4u3vA:
undetectable
3nluB-4u3vA:
undetectable		 3nluA-4u3vA:
19.43
3nluB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NOS_A_H4BA511_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.02A 3nosA-4u3vA:
undetectable
3nosB-4u3vA:
undetectable		 3nosA-4u3vA:
20.77
3nosB-4u3vA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NOS_B_H4BB1011_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.01A 3nosA-4u3vA:
undetectable
3nosB-4u3vA:
undetectable		 3nosA-4u3vA:
20.77
3nosB-4u3vA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 5 LEU A 179
SER A 183
LEU A 163
PRO A 164
 None
 0.68A 3onnA-4u3vA:
undetectable		 3onnA-4u3vA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNH_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.04A 3pnhA-4u3vA:
undetectable
3pnhB-4u3vA:
undetectable		 3pnhA-4u3vA:
20.24
3pnhB-4u3vA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNH_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.03A 3pnhA-4u3vA:
undetectable
3pnhB-4u3vA:
undetectable		 3pnhA-4u3vA:
20.24
3pnhB-4u3vA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQO_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.04A 3rqoA-4u3vA:
undetectable
3rqoB-4u3vA:
undetectable		 3rqoA-4u3vA:
19.47
3rqoB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQO_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.05A 3rqoA-4u3vA:
undetectable
3rqoB-4u3vA:
undetectable		 3rqoA-4u3vA:
19.47
3rqoB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQP_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.04A 3rqpA-4u3vA:
undetectable
3rqpB-4u3vA:
undetectable		 3rqpA-4u3vA:
19.47
3rqpB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		5 / 12 ILE A 206
GLY A 253
ILE A 224
ASN A 182
LEU A 256
 None
 1.21A 4a81A-4u3vA:
undetectable		 4a81A-4u3vA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C3A_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 4c3aA-4u3vA:
undetectable
4c3aB-4u3vA:
undetectable		 4c3aA-4u3vA:
19.47
4c3aB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C3A_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 4c3aA-4u3vA:
undetectable
4c3aB-4u3vA:
undetectable		 4c3aA-4u3vA:
19.47
4c3aB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAR_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.02A 4carA-4u3vA:
undetectable
4carB-4u3vA:
undetectable		 4carA-4u3vA:
19.47
4carB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAR_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.04A 4carA-4u3vA:
undetectable
4carB-4u3vA:
undetectable		 4carA-4u3vA:
19.47
4carB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CFT_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.05A 4cftA-4u3vA:
undetectable
4cftB-4u3vA:
undetectable		 4cftA-4u3vA:
19.47
4cftB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CFT_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.07A 4cftA-4u3vA:
undetectable
4cftB-4u3vA:
undetectable		 4cftA-4u3vA:
19.47
4cftB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.05A 4ctyA-4u3vA:
undetectable
4ctyB-4u3vA:
undetectable		 4ctyA-4u3vA:
19.47
4ctyB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.03A 4ctyA-4u3vA:
undetectable
4ctyB-4u3vA:
undetectable		 4ctyA-4u3vA:
19.47
4ctyB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 4ctzA-4u3vA:
undetectable
4ctzB-4u3vA:
undetectable		 4ctzA-4u3vA:
19.47
4ctzB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTZ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.04A 4ctzA-4u3vA:
undetectable
4ctzB-4u3vA:
undetectable		 4ctzA-4u3vA:
19.47
4ctzB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU0_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.04A 4cu0A-4u3vA:
undetectable
4cu0B-4u3vA:
undetectable		 4cu0A-4u3vA:
19.47
4cu0B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU0_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 4cu0A-4u3vA:
undetectable
4cu0B-4u3vA:
undetectable		 4cu0A-4u3vA:
19.47
4cu0B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU1_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.02A 4cu1A-4u3vA:
undetectable
4cu1B-4u3vA:
undetectable		 4cu1A-4u3vA:
19.47
4cu1B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU1_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.05A 4cu1A-4u3vA:
undetectable
4cu1B-4u3vA:
undetectable		 4cu1A-4u3vA:
19.47
4cu1B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWV_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.04A 4cwvA-4u3vA:
undetectable
4cwvB-4u3vA:
undetectable		 4cwvA-4u3vA:
19.47
4cwvB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWV_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 4cwvA-4u3vA:
undetectable
4cwvB-4u3vA:
undetectable		 4cwvA-4u3vA:
19.47
4cwvB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWW_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 4cwwA-4u3vA:
undetectable
4cwwB-4u3vA:
undetectable		 4cwwA-4u3vA:
19.47
4cwwB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWW_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.02A 4cwwA-4u3vA:
undetectable
4cwwB-4u3vA:
undetectable		 4cwwA-4u3vA:
19.47
4cwwB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 4cwxA-4u3vA:
undetectable
4cwxB-4u3vA:
undetectable		 4cwxA-4u3vA:
19.47
4cwxB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 4cwxA-4u3vA:
undetectable
4cwxB-4u3vA:
undetectable		 4cwxA-4u3vA:
19.47
4cwxB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 4cwyA-4u3vA:
undetectable
4cwyB-4u3vA:
undetectable		 4cwyA-4u3vA:
19.47
4cwyB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.05A 4cwyA-4u3vA:
undetectable
4cwyB-4u3vA:
undetectable		 4cwyA-4u3vA:
19.47
4cwyB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.04A 4cwzA-4u3vA:
undetectable
4cwzB-4u3vA:
undetectable		 4cwzA-4u3vA:
19.47
4cwzB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWZ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.02A 4cwzA-4u3vA:
undetectable
4cwzB-4u3vA:
undetectable		 4cwzA-4u3vA:
19.47
4cwzB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX0_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.05A 4cx0A-4u3vA:
undetectable
4cx0B-4u3vA:
undetectable		 4cx0A-4u3vA:
19.47
4cx0B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX0_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.05A 4cx0A-4u3vA:
undetectable
4cx0B-4u3vA:
undetectable		 4cx0A-4u3vA:
19.47
4cx0B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.02A 4cx3A-4u3vA:
undetectable
4cx3B-4u3vA:
undetectable		 4cx3A-4u3vA:
20.81
4cx3B-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.01A 4cx3A-4u3vA:
undetectable
4cx3B-4u3vA:
undetectable		 4cx3A-4u3vA:
20.81
4cx3B-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.01A 4cx4A-4u3vA:
undetectable
4cx4B-4u3vA:
undetectable		 4cx4A-4u3vA:
20.81
4cx4B-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.00A 4cx4A-4u3vA:
undetectable
4cx4B-4u3vA:
undetectable		 4cx4A-4u3vA:
20.81
4cx4B-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1O_A_H4BA1481_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.08A 4d1oA-4u3vA:
undetectable
4d1oB-4u3vA:
undetectable		 4d1oA-4u3vA:
20.76
4d1oB-4u3vA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1O_B_H4BB1481_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 4d1oA-4u3vA:
undetectable
4d1oB-4u3vA:
undetectable		 4d1oA-4u3vA:
20.76
4d1oB-4u3vA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1P_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.07A 4d1pA-4u3vA:
undetectable
4d1pB-4u3vA:
undetectable		 4d1pA-4u3vA:
20.76
4d1pB-4u3vA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.04A 4d33A-4u3vA:
undetectable
4d33B-4u3vA:
undetectable		 4d33A-4u3vA:
19.47
4d33B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 4d33A-4u3vA:
undetectable
4d33B-4u3vA:
undetectable		 4d33A-4u3vA:
19.47
4d33B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D34_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.10A 4d34A-4u3vA:
undetectable
4d34B-4u3vA:
undetectable		 4d34A-4u3vA:
19.47
4d34B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D34_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.08A 4d34A-4u3vA:
undetectable
4d34B-4u3vA:
undetectable		 4d34A-4u3vA:
19.47
4d34B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D35_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.10A 4d35A-4u3vA:
undetectable
4d35B-4u3vA:
undetectable		 4d35A-4u3vA:
19.47
4d35B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D36_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.02A 4d36A-4u3vA:
undetectable
4d36B-4u3vA:
undetectable		 4d36A-4u3vA:
19.47
4d36B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D36_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 4d36A-4u3vA:
undetectable
4d36B-4u3vA:
undetectable		 4d36A-4u3vA:
19.47
4d36B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D37_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 4d37A-4u3vA:
undetectable
4d37B-4u3vA:
undetectable		 4d37A-4u3vA:
19.47
4d37B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D37_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.05A 4d37A-4u3vA:
undetectable
4d37B-4u3vA:
undetectable		 4d37A-4u3vA:
19.47
4d37B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D38_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.07A 4d38A-4u3vA:
undetectable
4d38B-4u3vA:
undetectable		 4d38A-4u3vA:
19.47
4d38B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D38_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.07A 4d38A-4u3vA:
undetectable
4d38B-4u3vA:
undetectable		 4d38A-4u3vA:
19.47
4d38B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.04A 4d39A-4u3vA:
undetectable
4d39B-4u3vA:
undetectable		 4d39A-4u3vA:
19.47
4d39B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.03A 4d39A-4u3vA:
undetectable
4d39B-4u3vA:
undetectable		 4d39A-4u3vA:
19.47
4d39B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D3A_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.06A 4d3aA-4u3vA:
undetectable
4d3aB-4u3vA:
undetectable		 4d3aA-4u3vA:
19.47
4d3aB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D3A_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.08A 4d3aA-4u3vA:
undetectable
4d3aB-4u3vA:
undetectable		 4d3aA-4u3vA:
19.47
4d3aB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMX_A_H4BA502_1
(SUBUNIT A)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.05A 4imxA-4u3vA:
undetectable
4imxB-4u3vA:
undetectable		 4imxA-4u3vA:
19.07
4imxB-4u3vA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMX_B_H4BB502_1
(SUBUNIT A)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.03A 4imxA-4u3vA:
undetectable
4imxB-4u3vA:
undetectable		 4imxA-4u3vA:
19.07
4imxB-4u3vA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSK_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 4jskA-4u3vA:
undetectable
4jskB-4u3vA:
undetectable		 4jskA-4u3vA:
19.47
4jskB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSL_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 4jslA-4u3vA:
undetectable
4jslB-4u3vA:
undetectable		 4jslA-4u3vA:
19.47
4jslB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSL_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.03A 4jslA-4u3vA:
undetectable
4jslB-4u3vA:
undetectable		 4jslA-4u3vA:
19.47
4jslB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSM_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.06A 4jsmA-4u3vA:
undetectable
4jsmB-4u3vA:
undetectable		 4jsmA-4u3vA:
19.47
4jsmB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSM_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.04A 4jsmA-4u3vA:
undetectable
4jsmB-4u3vA:
undetectable		 4jsmA-4u3vA:
19.47
4jsmB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5H_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.07A 4k5hA-4u3vA:
undetectable
4k5hB-4u3vA:
undetectable		 4k5hA-4u3vA:
19.47
4k5hB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5H_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 4k5hA-4u3vA:
undetectable
4k5hB-4u3vA:
undetectable		 4k5hA-4u3vA:
19.47
4k5hB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5I_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 4k5iA-4u3vA:
undetectable
4k5iB-4u3vA:
undetectable		 4k5iA-4u3vA:
19.47
4k5iB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5I_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.09A 4k5iA-4u3vA:
undetectable
4k5iB-4u3vA:
undetectable		 4k5iA-4u3vA:
19.47
4k5iB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.06A 4k5jA-4u3vA:
undetectable
4k5jB-4u3vA:
undetectable		 4k5jA-4u3vA:
19.47
4k5jB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.10A 4k5jA-4u3vA:
undetectable
4k5jB-4u3vA:
undetectable		 4k5jA-4u3vA:
19.47
4k5jB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5K_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 4k5kA-4u3vA:
undetectable
4k5kB-4u3vA:
undetectable		 4k5kA-4u3vA:
19.47
4k5kB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5K_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.05A 4k5kA-4u3vA:
undetectable
4k5kB-4u3vA:
undetectable		 4k5kA-4u3vA:
19.47
4k5kB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCP_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 0.99A 4kcpA-4u3vA:
undetectable
4kcpB-4u3vA:
undetectable		 4kcpA-4u3vA:
19.47
4kcpB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCP_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.04A 4kcpA-4u3vA:
undetectable
4kcpB-4u3vA:
undetectable		 4kcpA-4u3vA:
19.47
4kcpB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCQ_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 0.99A 4kcqA-4u3vA:
undetectable
4kcqB-4u3vA:
undetectable		 4kcqA-4u3vA:
19.47
4kcqB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCQ_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.04A 4kcqA-4u3vA:
undetectable
4kcqB-4u3vA:
undetectable		 4kcqA-4u3vA:
19.47
4kcqB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCR_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.01A 4kcrA-4u3vA:
undetectable
4kcrB-4u3vA:
undetectable		 4kcrA-4u3vA:
19.47
4kcrB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCR_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.05A 4kcrA-4u3vA:
undetectable
4kcrB-4u3vA:
undetectable		 4kcrA-4u3vA:
19.47
4kcrB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCS_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.02A 4kcsA-4u3vA:
undetectable
4kcsB-4u3vA:
undetectable		 4kcsA-4u3vA:
19.47
4kcsB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCS_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.03A 4kcsA-4u3vA:
undetectable
4kcsB-4u3vA:
undetectable		 4kcsA-4u3vA:
19.47
4kcsB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUW_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.04A 4luwA-4u3vA:
undetectable
4luwB-4u3vA:
undetectable		 4luwA-4u3vA:
19.51
4luwB-4u3vA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUW_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.04A 4luwA-4u3vA:
undetectable
4luwB-4u3vA:
undetectable		 4luwA-4u3vA:
19.51
4luwB-4u3vA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.06A 4uh7A-4u3vA:
undetectable
4uh7B-4u3vA:
undetectable		 4uh7A-4u3vA:
19.47
4uh7B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 4uh7A-4u3vA:
undetectable
4uh7B-4u3vA:
undetectable		 4uh7A-4u3vA:
19.47
4uh7B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH8_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 4uh8A-4u3vA:
undetectable
4uh8B-4u3vA:
undetectable		 4uh8A-4u3vA:
19.47
4uh8B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH8_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.05A 4uh8A-4u3vA:
undetectable
4uh8B-4u3vA:
undetectable		 4uh8A-4u3vA:
19.47
4uh8B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH9_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.04A 4uh9A-4u3vA:
undetectable
4uh9B-4u3vA:
undetectable		 4uh9A-4u3vA:
19.47
4uh9B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH9_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.07A 4uh9A-4u3vA:
undetectable
4uh9B-4u3vA:
undetectable		 4uh9A-4u3vA:
19.47
4uh9B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHA_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 4uhaA-4u3vA:
undetectable
4uhaB-4u3vA:
undetectable		 4uhaA-4u3vA:
19.47
4uhaB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHA_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.07A 4uhaA-4u3vA:
undetectable
4uhaB-4u3vA:
undetectable		 4uhaA-4u3vA:
19.47
4uhaB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPQ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 4upqA-4u3vA:
undetectable
4upqB-4u3vA:
undetectable		 4upqA-4u3vA:
19.47
4upqB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPQ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.04A 4upqA-4u3vA:
undetectable
4upqB-4u3vA:
undetectable		 4upqA-4u3vA:
19.47
4upqB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPR_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.01A 4uprA-4u3vA:
undetectable
4uprB-4u3vA:
undetectable		 4uprA-4u3vA:
19.47
4uprB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPR_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.05A 4uprA-4u3vA:
undetectable
4uprB-4u3vA:
undetectable		 4uprA-4u3vA:
19.47
4uprB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPS_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.04A 4upsA-4u3vA:
undetectable
4upsB-4u3vA:
undetectable		 4upsA-4u3vA:
19.47
4upsB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPS_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 4upsA-4u3vA:
undetectable
4upsB-4u3vA:
undetectable		 4upsA-4u3vA:
19.47
4upsB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPT_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 4uptA-4u3vA:
undetectable
4uptB-4u3vA:
undetectable		 4uptA-4u3vA:
19.47
4uptB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPT_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.08A 4uptA-4u3vA:
undetectable
4uptB-4u3vA:
undetectable		 4uptA-4u3vA:
19.47
4uptB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.03A 5addA-4u3vA:
undetectable
5addB-4u3vA:
undetectable		 5addA-4u3vA:
20.81
5addB-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.03A 5adeA-4u3vA:
undetectable
5adeB-4u3vA:
undetectable		 5adeA-4u3vA:
20.81
5adeB-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADJ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.07A 5adjA-4u3vA:
undetectable
5adjB-4u3vA:
undetectable		 5adjA-4u3vA:
19.47
5adjB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADJ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.08A 5adjA-4u3vA:
undetectable
5adjB-4u3vA:
undetectable		 5adjA-4u3vA:
19.47
5adjB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADK_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.04A 5adkA-4u3vA:
undetectable
5adkB-4u3vA:
undetectable		 5adkA-4u3vA:
19.47
5adkB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADK_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.07A 5adkA-4u3vA:
undetectable
5adkB-4u3vA:
undetectable		 5adkA-4u3vA:
19.47
5adkB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.06A 5adlA-4u3vA:
undetectable
5adlB-4u3vA:
undetectable		 5adlA-4u3vA:
19.47
5adlB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.07A 5adlA-4u3vA:
undetectable
5adlB-4u3vA:
undetectable		 5adlA-4u3vA:
19.47
5adlB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADM_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.05A 5admA-4u3vA:
undetectable
5admB-4u3vA:
undetectable		 5admA-4u3vA:
19.47
5admB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADM_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 5admA-4u3vA:
undetectable
5admB-4u3vA:
undetectable		 5admA-4u3vA:
19.47
5admB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADN_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.05A 5adnA-4u3vA:
undetectable
5adnB-4u3vA:
undetectable		 5adnA-4u3vA:
19.47
5adnB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADN_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.08A 5adnA-4u3vA:
undetectable
5adnB-4u3vA:
undetectable		 5adnA-4u3vA:
19.47
5adnB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ2_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.04A 5fj2A-4u3vA:
undetectable
5fj2B-4u3vA:
undetectable		 5fj2A-4u3vA:
19.47
5fj2B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ2_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 5fj2A-4u3vA:
undetectable
5fj2B-4u3vA:
undetectable		 5fj2A-4u3vA:
19.47
5fj2B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.02A 5fj3A-4u3vA:
undetectable
5fj3B-4u3vA:
undetectable		 5fj3A-4u3vA:
19.47
5fj3B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.05A 5fj3A-4u3vA:
undetectable
5fj3B-4u3vA:
undetectable		 5fj3A-4u3vA:
19.47
5fj3B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.06A 5fvyA-4u3vA:
undetectable
5fvyB-4u3vA:
undetectable		 5fvyA-4u3vA:
19.47
5fvyB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.08A 5fvyA-4u3vA:
undetectable
5fvyB-4u3vA:
undetectable		 5fvyA-4u3vA:
19.47
5fvyB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVZ_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.06A 5fvzA-4u3vA:
undetectable
5fvzB-4u3vA:
undetectable		 5fvzA-4u3vA:
19.47
5fvzB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVZ_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.04A 5fvzA-4u3vA:
undetectable
5fvzB-4u3vA:
undetectable		 5fvzA-4u3vA:
19.47
5fvzB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.00A 5g0pA-4u3vA:
undetectable
5g0pB-4u3vA:
undetectable		 5g0pA-4u3vA:
20.81
5g0pB-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.04A 5g0pA-4u3vA:
undetectable
5g0pB-4u3vA:
undetectable		 5g0pA-4u3vA:
20.81
5g0pB-4u3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.09A 5uo8A-4u3vA:
undetectable
5uo8B-4u3vA:
undetectable		 5uo8A-4u3vA:
20.76
5uo8B-4u3vA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.01A 5uo8C-4u3vA:
0.0
5uo8D-4u3vA:
undetectable		 5uo8C-4u3vA:
20.76
5uo8D-4u3vA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.08A 5uo8C-4u3vA:
0.0
5uo8D-4u3vA:
undetectable		 5uo8C-4u3vA:
20.76
5uo8D-4u3vA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.05A 5uo9A-4u3vA:
undetectable
5uo9B-4u3vA:
undetectable		 5uo9A-4u3vA:
20.76
5uo9B-4u3vA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.09A 5uo9A-4u3vA:
undetectable
5uo9B-4u3vA:
undetectable		 5uo9A-4u3vA:
20.76
5uo9B-4u3vA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.08A 5uo9C-4u3vA:
0.0
5uo9D-4u3vA:
undetectable		 5uo9C-4u3vA:
20.76
5uo9D-4u3vA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.05A 5uo9C-4u3vA:
0.0
5uo9D-4u3vA:
undetectable		 5uo9C-4u3vA:
20.76
5uo9D-4u3vA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOD_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 5uodA-4u3vA:
undetectable
5uodB-4u3vA:
undetectable		 5uodA-4u3vA:
19.47
5uodB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.02A 5uodA-4u3vA:
undetectable
5uodB-4u3vA:
undetectable		 5uodA-4u3vA:
19.47
5uodB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV6_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.02A 5vv6A-4u3vA:
undetectable
5vv6B-4u3vA:
undetectable		 5vv6A-4u3vA:
19.47
5vv6B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV6_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 5vv6A-4u3vA:
undetectable
5vv6B-4u3vA:
undetectable		 5vv6A-4u3vA:
19.47
5vv6B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.02A 5vv7A-4u3vA:
undetectable
5vv7B-4u3vA:
undetectable		 5vv7A-4u3vA:
19.47
5vv7B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 5vv7A-4u3vA:
undetectable
5vv7B-4u3vA:
undetectable		 5vv7A-4u3vA:
19.47
5vv7B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.01A 5vv8A-4u3vA:
undetectable
5vv8B-4u3vA:
undetectable		 5vv8A-4u3vA:
19.47
5vv8B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV8_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.05A 5vv8A-4u3vA:
undetectable
5vv8B-4u3vA:
undetectable		 5vv8A-4u3vA:
19.47
5vv8B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.02A 5vv9A-4u3vA:
undetectable
5vv9B-4u3vA:
undetectable		 5vv9A-4u3vA:
19.47
5vv9B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.11A 5vv9A-4u3vA:
undetectable
5vv9B-4u3vA:
undetectable		 5vv9A-4u3vA:
19.47
5vv9B-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.04A 5vvaA-4u3vA:
undetectable
5vvaB-4u3vA:
undetectable		 5vvaA-4u3vA:
19.47
5vvaB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.08A 5vvaA-4u3vA:
undetectable
5vvaB-4u3vA:
undetectable		 5vvaA-4u3vA:
19.47
5vvaB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVB_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.01A 5vvbA-4u3vA:
0.0
5vvbB-4u3vA:
undetectable		 5vvbA-4u3vA:
20.76
5vvbB-4u3vA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVB_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.01A 5vvbC-4u3vA:
undetectable
5vvbD-4u3vA:
undetectable		 5vvbC-4u3vA:
20.76
5vvbD-4u3vA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVC_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.02A 5vvcA-4u3vA:
undetectable
5vvcB-4u3vA:
undetectable		 5vvcA-4u3vA:
20.76
5vvcB-4u3vA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVC_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 5vvcC-4u3vA:
undetectable
5vvcD-4u3vA:
undetectable		 5vvcC-4u3vA:
20.76
5vvcD-4u3vA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVC_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 5vvcC-4u3vA:
undetectable
5vvcD-4u3vA:
undetectable		 5vvcC-4u3vA:
20.76
5vvcD-4u3vA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.05A 5vvdA-4u3vA:
undetectable
5vvdB-4u3vA:
undetectable		 5vvdA-4u3vA:
20.76
5vvdB-4u3vA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.09A 5vvdC-4u3vA:
0.0
5vvdD-4u3vA:
undetectable		 5vvdC-4u3vA:
20.76
5vvdD-4u3vA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVG_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 5vvgA-4u3vA:
undetectable
5vvgB-4u3vA:
undetectable		 5vvgA-4u3vA:
19.47
5vvgB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVG_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 5vvgA-4u3vA:
undetectable
5vvgB-4u3vA:
undetectable		 5vvgA-4u3vA:
19.47
5vvgB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.03A 5vvnA-4u3vA:
undetectable
5vvnB-4u3vA:
undetectable		 5vvnA-4u3vA:
19.47
5vvnB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 5vvnA-4u3vA:
undetectable
5vvnB-4u3vA:
undetectable		 5vvnA-4u3vA:
19.47
5vvnB-4u3vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.11A 6av6A-4u3vA:
undetectable
6av6B-4u3vA:
undetectable		 6av6A-4u3vA:
13.10
6av6B-4u3vA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB503_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.07A 6av6A-4u3vA:
undetectable
6av6B-4u3vA:
undetectable		 6av6A-4u3vA:
13.10
6av6B-4u3vA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.13A 6av6C-4u3vA:
undetectable
6av6D-4u3vA:
undetectable		 6av6C-4u3vA:
13.10
6av6D-4u3vA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.09A 6av6C-4u3vA:
undetectable
6av6D-4u3vA:
undetectable		 6av6C-4u3vA:
13.10
6av6D-4u3vA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.08A 6av7A-4u3vA:
undetectable
6av7B-4u3vA:
undetectable		 6av7A-4u3vA:
13.10
6av7B-4u3vA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.08A 6av7A-4u3vA:
undetectable
6av7B-4u3vA:
undetectable		 6av7A-4u3vA:
13.10
6av7B-4u3vA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.13A 6av7C-4u3vA:
undetectable
6av7D-4u3vA:
undetectable		 6av7C-4u3vA:
13.10
6av7D-4u3vA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.05A 6av7C-4u3vA:
undetectable
6av7D-4u3vA:
undetectable		 6av7C-4u3vA:
13.10
6av7D-4u3vA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_A_H4BA502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.09A 6cieA-4u3vA:
0.0
6cieB-4u3vA:
undetectable		 6cieA-4u3vA:
13.10
6cieB-4u3vA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 6cieA-4u3vA:
0.0
6cieB-4u3vA:
undetectable		 6cieA-4u3vA:
13.10
6cieB-4u3vA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.08A 6cieC-4u3vA:
0.0
6cieD-4u3vA:
undetectable		 6cieC-4u3vA:
13.10
6cieD-4u3vA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_D_H4BD502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.06A 6cieC-4u3vA:
0.0
6cieD-4u3vA:
undetectable		 6cieC-4u3vA:
13.10
6cieD-4u3vA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_A_H4BA502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.12A 6cifA-4u3vA:
0.0
6cifB-4u3vA:
0.0		 6cifA-4u3vA:
13.10
6cifB-4u3vA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.04A 6cifA-4u3vA:
undetectable
6cifB-4u3vA:
undetectable		 6cifA-4u3vA:
13.10
6cifB-4u3vA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 7 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.12A 6cifC-4u3vA:
0.0
6cifD-4u3vA:
undetectable		 6cifC-4u3vA:
13.10
6cifD-4u3vA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_D_H4BD502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.09A 6cifC-4u3vA:
0.0
6cifD-4u3vA:
0.0		 6cifC-4u3vA:
13.10
6cifD-4u3vA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8NSE_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.05A 8nseA-4u3vA:
undetectable
8nseB-4u3vA:
undetectable		 8nseA-4u3vA:
19.43
8nseB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8NSE_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.10A 8nseA-4u3vA:
undetectable
8nseB-4u3vA:
undetectable		 8nseA-4u3vA:
19.43
8nseB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9NSE_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 VAL A  19
TRP A 140
PHE A 144
GLU A 139
 None
 1.02A 9nseA-4u3vA:
undetectable
9nseB-4u3vA:
undetectable		 9nseA-4u3vA:
19.43
9nseB-4u3vA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9NSE_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4u3v POLYKETIDE SYNTHASE
PKSR
(Bacillus
subtilis) 		4 / 6 TRP A 140
PHE A 144
GLU A 139
VAL A  19
 None
 1.05A 9nseA-4u3vA:
undetectable
9nseB-4u3vA:
undetectable		 9nseA-4u3vA:
19.43
9nseB-4u3vA:
19.43