SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u49'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 4u49 PECTATE LYASE
(Pectobacterium
carotovorum) 		4 / 6 LEU A 144
ILE A 169
ASP A 176
PRO A 154
 None
 1.12A 1ditH-4u49A:
undetectable
1ditP-4u49A:
undetectable		 1ditH-4u49A:
23.45
1ditP-4u49A:
4.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 4u49 PECTATE LYASE
(Pectobacterium
carotovorum) 		5 / 9 LEU A 246
ILE A 280
LEU A 269
VAL A 311
LEU A 299
 None
 1.07A 1e7aB-4u49A:
undetectable		 1e7aB-4u49A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4u49 PECTATE LYASE
(Pectobacterium
carotovorum) 		5 / 12 LEU A 159
TRP A 192
GLY A 177
LEU A 167
ILE A 164
 None
 1.18A 1kyvC-4u49A:
undetectable
1kyvD-4u49A:
undetectable		 1kyvC-4u49A:
18.34
1kyvD-4u49A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4u49 PECTATE LYASE
(Pectobacterium
carotovorum) 		5 / 12 LEU A 159
TRP A 192
GLY A 177
LEU A 167
ILE A 164
 None
 1.20A 1kyvD-4u49A:
undetectable
1kyvE-4u49A:
undetectable		 1kyvD-4u49A:
18.34
1kyvE-4u49A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4u49 PECTATE LYASE
(Pectobacterium
carotovorum) 		5 / 12 GLY A 317
GLY A 258
ARG A 267
ASN A 336
GLU A 319
 None
 0.96A 3ckkA-4u49A:
undetectable		 3ckkA-4u49A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 4u49 PECTATE LYASE
(Pectobacterium
carotovorum) 		5 / 12 THR A  24
VAL A  51
TYR A  88
SER A  71
THR A 275
 None
 1.32A 3frqA-4u49A:
undetectable		 3frqA-4u49A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4u49 PECTATE LYASE
(Pectobacterium
carotovorum) 		5 / 12 ASN A 277
VAL A 276
GLY A 212
TYR A  36
MET A  27
 None
 1.48A 5fhrA-4u49A:
undetectable		 5fhrA-4u49A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 4u49 PECTATE LYASE
(Pectobacterium
carotovorum) 		4 / 7 ASP A 176
GLY A 177
HIS A 179
ASP A 198
 None
 1.06A 5nnwD-4u49A:
undetectable		 5nnwD-4u49A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 4u49 PECTATE LYASE
(Pectobacterium
carotovorum) 		5 / 12 LEU A 142
VAL A 156
SER A  40
TRP A  39
GLY A 211
 None
 1.38A 6mn8A-4u49A:
undetectable		 6mn8A-4u49A:
19.11