SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u4e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		4 / 7 ARG A 343
VAL A 342
ASN A 321
LYS A 177
 None
 1.10A 1hwiC-4u4eA:
undetectable		 1hwiC-4u4eA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		4 / 7 ARG A 343
VAL A 342
ASN A 321
LYS A 177
 None
 1.11A 1hwiD-4u4eA:
undetectable		 1hwiD-4u4eA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 9 THR A 328
GLY A  20
GLY A 212
SER A  16
GLY A 107
 None
 1.09A 1jhoA-4u4eA:
undetectable		 1jhoA-4u4eA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 9 THR A 328
GLY A  20
GLY A 212
SER A  16
GLY A 107
 None
 1.11A 1jhrA-4u4eA:
undetectable		 1jhrA-4u4eA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 9 THR A 328
GLY A  20
GLY A 212
SER A  16
GLY A 107
 None
 1.07A 1jhyA-4u4eA:
undetectable		 1jhyA-4u4eA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 9 THR A 328
GLY A  20
GLY A 212
SER A  16
GLY A 107
 None
 1.07A 1l4nA-4u4eA:
undetectable		 1l4nA-4u4eA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 9 THR A 328
GLY A  20
GLY A 212
SER A  16
GLY A 107
 None
 1.08A 1l5kA-4u4eA:
undetectable		 1l5kA-4u4eA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 9 THR A 328
GLY A  20
GLY A 212
SER A  16
GLY A 107
 None
 1.07A 1l5lA-4u4eA:
undetectable		 1l5lA-4u4eA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 9 THR A 328
GLY A  20
GLY A 212
SER A  16
GLY A 107
 None
 1.06A 1l5mA-4u4eA:
undetectable		 1l5mA-4u4eA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		4 / 4 ALA A  91
VAL A  95
ALA A  92
HIS A  89
 None
 0.89A 1q23A-4u4eA:
undetectable		 1q23A-4u4eA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		4 / 4 ALA A  91
VAL A  95
ALA A  92
HIS A  89
 None
 0.92A 1q23F-4u4eA:
undetectable		 1q23F-4u4eA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		4 / 4 ALA A  91
VAL A  95
ALA A  92
HIS A  89
 None
 0.93A 1q23K-4u4eA:
undetectable		 1q23K-4u4eA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		4 / 4 ASP A 292
LEU A 287
LEU A 290
LEU A 288
 None
 1.41A 1u18A-4u4eA:
undetectable		 1u18A-4u4eA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 12 ALA A  55
GLY A  75
ILE A  57
SER A  58
ILE A  85
 None
 1.12A 1ve3A-4u4eA:
undetectable		 1ve3A-4u4eA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 12 ALA A  55
GLY A  75
ILE A  57
SER A  58
ILE A  85
 None
 1.12A 1ve3B-4u4eA:
undetectable		 1ve3B-4u4eA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		4 / 8 GLY A 376
GLY A 259
ALA A 261
ALA A 262
 None
 0.59A 2ej3A-4u4eA:
undetectable		 2ej3A-4u4eA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 12 LEU A  39
ILE A 104
ALA A 213
ALA A  38
LEU A  66
 None
 1.05A 2japA-4u4eA:
undetectable		 2japA-4u4eA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 12 LEU A  39
ILE A 104
ALA A 213
ALA A  38
LEU A  66
 None
 1.03A 2japB-4u4eA:
undetectable		 2japB-4u4eA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 12 LEU A  39
ILE A 104
ALA A 213
ALA A  38
LEU A  66
 None
 1.06A 2japC-4u4eA:
undetectable		 2japC-4u4eA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 12 LEU A  39
ILE A 104
ALA A 213
ALA A  38
LEU A  66
 None
 1.03A 2japD-4u4eA:
undetectable		 2japD-4u4eA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 12 ILE A 379
ALA A   9
GLY A   6
GLY A 234
PRO A 229
 None
 1.15A 2okcA-4u4eA:
undetectable		 2okcA-4u4eA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 12 ILE A 379
ALA A   9
GLY A   6
GLY A 234
PRO A 229
 None
 1.10A 2okcB-4u4eA:
undetectable		 2okcB-4u4eA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		4 / 5 VAL A 101
THR A 217
VAL A  11
GLY A  12
 None
 1.11A 2p2fA-4u4eA:
undetectable		 2p2fA-4u4eA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		4 / 4 VAL A 101
THR A 217
VAL A  11
GLY A  12
 None
 1.16A 2p2fB-4u4eA:
undetectable		 2p2fB-4u4eA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		4 / 6 THR A 328
TYR A 349
TRP A 171
MET A 277
 None
 1.48A 2qmjA-4u4eA:
undetectable		 2qmjA-4u4eA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 12 ILE A 278
ILE A 186
THR A 168
LEU A 325
LEU A 287
 None
 1.08A 2qo5A-4u4eA:
undetectable		 2qo5A-4u4eA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 12 GLY A 334
HIS A  86
VAL A 216
SER A  82
GLY A 234
 None
 1.04A 2vmyA-4u4eA:
undetectable		 2vmyA-4u4eA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 12 VAL A  84
ALA A  90
ALA A  91
ALA A 102
VAL A 365
 None
 0.89A 3fc6C-4u4eA:
undetectable		 3fc6C-4u4eA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 12 ALA A 375
GLY A 367
ASP A 240
GLY A 259
SER A 258
 None
 1.01A 3g2oB-4u4eA:
undetectable		 3g2oB-4u4eA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		4 / 7 LEU A 288
ASP A 292
SER A 252
TYR A 143
 None
 1.22A 4arcA-4u4eA:
undetectable		 4arcA-4u4eA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 9 ASN A 319
GLY A 323
GLY A 322
GLY A 324
ASP A 280
 None
 1.48A 4h2fA-4u4eA:
undetectable		 4h2fA-4u4eA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 11 ALA A  88
ALA A  90
ALA A  91
THR A   8
LEU A 380
 None
 1.13A 4j6cA-4u4eA:
undetectable		 4j6cA-4u4eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 10 ALA A  88
ALA A  90
ALA A  91
THR A   8
LEU A 380
 None
 1.12A 4j6cB-4u4eA:
undetectable		 4j6cB-4u4eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 12 ALA A  88
ALA A  90
ALA A  91
THR A   8
LEU A 380
 None
 1.09A 4j6dA-4u4eA:
undetectable		 4j6dA-4u4eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 12 ALA A  88
ALA A  90
ALA A  91
THR A   8
LEU A 380
 None
 1.10A 4j6dB-4u4eA:
undetectable		 4j6dB-4u4eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 12 ALA A  88
ALA A  90
ALA A  91
THR A   8
LEU A 380
 None
 1.08A 4jbtA-4u4eA:
undetectable		 4jbtA-4u4eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 11 ALA A  88
ALA A  90
ALA A  91
THR A   8
LEU A 380
 None
 1.09A 4jbtB-4u4eA:
undetectable		 4jbtB-4u4eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 12 TYR A  72
CYH A  99
LEU A  87
ILE A 104
LEU A  52
 None
 1.48A 4k36B-4u4eA:
undetectable		 4k36B-4u4eA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 9 THR A 328
GLY A  20
GLY A 212
SER A  16
GLY A 107
 None
 1.17A 4kqiA-4u4eA:
undetectable		 4kqiA-4u4eA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 12 LEU A  53
ALA A  91
VAL A 216
ALA A 102
ILE A 232
 None
 1.04A 4x1kD-4u4eA:
undetectable		 4x1kD-4u4eA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 12 GLY A 367
GLY A 259
GLY A 376
VAL A 268
ILE A 273
 None
 0.95A 5kqrA-4u4eA:
undetectable		 5kqrA-4u4eA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_A_ACTA402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		4 / 5 CYH A 214
ILE A 338
HIS A 106
HIS A  86
 None
 1.05A 5ocsA-4u4eA:
undetectable		 5ocsA-4u4eA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_C_ACTC402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		4 / 5 CYH A 214
ILE A 338
HIS A 106
HIS A  86
 None
 1.06A 5ocsC-4u4eA:
undetectable		 5ocsC-4u4eA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 12 GLY A 367
GLY A 259
GLY A 376
VAL A 268
ILE A 273
 None
 0.95A 5vimA-4u4eA:
undetectable		 5vimA-4u4eA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		4 / 5 HIS A 366
ALA A 254
SER A 258
GLY A 376
 None
 1.17A 5yodB-4u4eA:
undetectable		 5yodB-4u4eA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		4 / 5 HIS A 366
ALA A 254
SER A 258
GLY A 376
 None
 1.20A 5yodD-4u4eA:
undetectable		 5yodD-4u4eA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 4u4e THIOLASE
(Sphaerobacter
thermophilus) 		5 / 12 LEU A  52
HIS A  31
ALA A  34
LEU A 103
GLY A 334
 None
 0.88A 6b0cD-4u4eA:
undetectable		 6b0cD-4u4eA:
12.47