SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u4h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 4u4h TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		3 / 3 THR A 124
PRO A 165
THR A 164
 None
 0.94A 1dscC-4u4hA:
undetectable		 1dscC-4u4hA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 4u4h TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		3 / 3 THR A 164
THR A 124
PRO A 165
 None
 0.83A 1dscC-4u4hA:
undetectable		 1dscC-4u4hA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4u4h TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		4 / 5 GLU A 147
LEU A 137
GLN A  -5
GLY A 136
 None
 1.13A 3pp1A-4u4hA:
undetectable		 3pp1A-4u4hA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4u4h TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		3 / 3 LEU A 180
PRO A 181
LEU A 184
 None
 0.43A 3w1wB-4u4hA:
undetectable		 3w1wB-4u4hA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 4u4h TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		5 / 12 TYR A  34
CYH A  29
VAL A 100
LEU A  72
LEU A 180
 None
 1.35A 4rtbA-4u4hA:
undetectable		 4rtbA-4u4hA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 4u4h TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		3 / 3 LYS A  49
ARG A  55
VAL A  54
 None
 0.77A 4x3uA-4u4hA:
undetectable
4x3uB-4u4hA:
undetectable		 4x3uA-4u4hA:
18.37
4x3uB-4u4hA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4u4h TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		4 / 4 LEU A 126
TYR A 168
PRO A 165
ILE A 154
 None
 1.35A 5esgA-4u4hA:
undetectable		 5esgA-4u4hA:
16.29