SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u4p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E6W_C_ESTC302_1
(SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4u4p STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
4
(Homo
sapiens) 		4 / 4 ALA B 728
GLN B 730
TYR B 729
LEU B 721
 None
 1.24A 1e6wC-4u4pB:
undetectable		 1e6wC-4u4pB:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4u4p STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2
STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
4
(Homo
sapiens) 		4 / 5 GLU A 568
ARG A 507
ASP B 578
LEU B 575
 None
 1.17A 1n13B-4u4pA:
undetectable
1n13C-4u4pA:
undetectable		 1n13B-4u4pA:
18.57
1n13C-4u4pA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 4u4p STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2
STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
4
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP B 641
GLU A 547
ARG A 668
 None
 0.81A 1wopA-4u4pB:
undetectable		 1wopA-4u4pB:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4u4p STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2
(Homo
sapiens) 		5 / 10 THR A 627
GLY A 546
VAL A 656
ASP A 658
VAL A 650
 None
 1.29A 2cp4A-4u4pA:
undetectable		 2cp4A-4u4pA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 4u4p STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2
(Homo
sapiens) 		3 / 3 GLU A 476
GLN A 484
ARG A 487
 None
 0.84A 2w3bB-4u4pA:
undetectable		 2w3bB-4u4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 4u4p STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
4
(Homo
sapiens) 		3 / 3 ASP B 722
THR B 690
PRO B 691
 None
 0.63A 3tkgD-4u4pB:
undetectable		 3tkgD-4u4pB:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4u4p STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2
(Homo
sapiens) 		4 / 5 ASP A 488
LEU A 492
GLU A 687
LYS A 691
 None
 0.63A 4a3pA-4u4pA:
undetectable		 4a3pA-4u4pA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 4u4p STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
4
(Homo
sapiens) 		3 / 3 VAL B 717
TYR B 629
ALA B 632
 None
 0.51A 4ybnA-4u4pB:
undetectable		 4ybnA-4u4pB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4u4p STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2
(Homo
sapiens) 		3 / 3 ARG A 566
LYS A 561
GLU A 565
 None
 0.73A 5d0yA-4u4pA:
undetectable		 5d0yA-4u4pA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4u4p STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2
(Homo
sapiens) 		4 / 7 THR A 574
LEU A 529
VAL A 610
GLN A 679
 None
 1.05A 5tudA-4u4pA:
4.9		 5tudA-4u4pA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4u4p STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
4
(Homo
sapiens) 		5 / 12 GLY B 597
LYS B 607
VAL B 645
ILE B 643
ASP B 641
 None
 1.14A 6bxmA-4u4pB:
undetectable		 6bxmA-4u4pB:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4u4p STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2
(Homo
sapiens) 		5 / 12 ASP A 555
ALA A 619
GLY A 524
PHE A 508
VAL A 526
 None
 1.27A 6clxA-4u4pA:
undetectable		 6clxA-4u4pA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 4u4p STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
4
(Homo
sapiens) 		3 / 3 ARG B 596
ARG B 618
ASP B 641
 None
 0.82A 6d8pA-4u4pB:
undetectable		 6d8pA-4u4pB:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 4u4p STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
4
(Homo
sapiens) 		4 / 5 PHE B 708
VAL B 717
MET B 763
VAL B 699
 None
 1.32A 6ekzA-4u4pB:
undetectable		 6ekzA-4u4pB:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4u4p STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2
STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
4
(Homo
sapiens;
Homo
sapiens) 		5 / 11 SER B 748
VAL A 526
GLY A 524
ALA A 509
VAL A 554
 None
 1.36A 6hu9A-4u4pB:
undetectable
6hu9E-4u4pB:
undetectable
6hu9I-4u4pB:
undetectable		 6hu9A-4u4pB:
21.74
6hu9E-4u4pB:
25.10
6hu9I-4u4pB:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4u4p STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
4
(Homo
sapiens) 		4 / 5 TYR B 709
ARG B 713
THR B 715
LEU B 716
 None
 1.15A 6nknW-4u4pB:
undetectable		 6nknW-4u4pB:
13.91