SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u5a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL
(Plasmodium
berghei) 		4 / 6 ASN A 119
ILE A 124
ASN A 125
SER A 126
 None
 1.16A 1h7xA-4u5aA:
undetectable		 1h7xA-4u5aA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL
(Plasmodium
berghei) 		4 / 6 ASN A 119
ILE A 124
ASN A 125
SER A 126
 None
 1.14A 1h7xB-4u5aA:
undetectable		 1h7xB-4u5aA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL
(Plasmodium
berghei) 		4 / 6 ASN A 119
ILE A 124
ASN A 125
SER A 126
 None
 1.15A 1h7xC-4u5aA:
undetectable		 1h7xC-4u5aA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL
(Plasmodium
berghei) 		4 / 6 ASN A 119
ILE A 124
ASN A 125
SER A 126
 None
 1.14A 1h7xD-4u5aA:
undetectable		 1h7xD-4u5aA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL
(Plasmodium
berghei) 		5 / 12 ILE A 163
LEU A 158
SER A 179
ILE A 180
LEU A 194
 None
 1.30A 3ia4B-4u5aA:
undetectable		 3ia4B-4u5aA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL
(Plasmodium
berghei) 		5 / 12 PHE A 115
ILE A 138
CYH A 142
LEU A  57
ASP A  60
 None
 1.27A 3ko0A-4u5aA:
1.7
3ko0B-4u5aA:
1.9
3ko0C-4u5aA:
1.9
3ko0D-4u5aA:
1.8		 3ko0A-4u5aA:
20.30
3ko0B-4u5aA:
20.30
3ko0C-4u5aA:
20.30
3ko0D-4u5aA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL
(Plasmodium
berghei) 		5 / 12 LEU A  57
ASP A  60
PHE A 115
ILE A 138
CYH A 142
 None
 1.24A 3ko0K-4u5aA:
undetectable
3ko0L-4u5aA:
1.8
3ko0M-4u5aA:
1.9
3ko0N-4u5aA:
1.9		 3ko0K-4u5aA:
20.30
3ko0L-4u5aA:
20.30
3ko0M-4u5aA:
20.30
3ko0N-4u5aA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL
(Plasmodium
berghei) 		5 / 12 PHE A 115
ILE A 138
CYH A 142
LEU A  57
ASP A  60
 None
 1.23A 3ko0M-4u5aA:
undetectable
3ko0N-4u5aA:
1.9
3ko0O-4u5aA:
1.9
3ko0P-4u5aA:
1.9		 3ko0M-4u5aA:
20.30
3ko0N-4u5aA:
20.30
3ko0O-4u5aA:
20.30
3ko0P-4u5aA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL
(Plasmodium
berghei) 		5 / 12 LEU A  57
ASP A  60
PHE A 115
ILE A 138
CYH A 142
 None
 1.24A 3ko0M-4u5aA:
1.9
3ko0N-4u5aA:
1.9
3ko0O-4u5aA:
1.9
3ko0P-4u5aA:
1.9		 3ko0M-4u5aA:
20.30
3ko0N-4u5aA:
20.30
3ko0O-4u5aA:
20.30
3ko0P-4u5aA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_C_P77C203_1
(PROTEIN S100-A4)		 4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL
(Plasmodium
berghei) 		5 / 10 PHE A 115
ILE A 138
CYH A 142
LEU A  57
ASP A  60
 None
 1.22A 3m0wC-4u5aA:
1.9
3m0wD-4u5aA:
1.8
3m0wE-4u5aA:
1.7
3m0wF-4u5aA:
1.8		 3m0wC-4u5aA:
19.80
3m0wD-4u5aA:
19.80
3m0wE-4u5aA:
19.80
3m0wF-4u5aA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_G_P77G203_1
(PROTEIN S100-A4)		 4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL
(Plasmodium
berghei) 		5 / 9 PHE A 115
ILE A 138
CYH A 142
LEU A  57
ASP A  60
 None
 1.20A 3m0wG-4u5aA:
1.8
3m0wH-4u5aA:
1.8
3m0wI-4u5aA:
1.8
3m0wJ-4u5aA:
1.9		 3m0wG-4u5aA:
19.80
3m0wH-4u5aA:
19.80
3m0wI-4u5aA:
19.80
3m0wJ-4u5aA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_H_P77H203_1
(PROTEIN S100-A4)		 4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL
(Plasmodium
berghei) 		5 / 10 LEU A  57
ASP A  60
PHE A 115
ILE A 138
CYH A 142
 None
 1.25A 3m0wE-4u5aA:
1.7
3m0wF-4u5aA:
1.8
3m0wG-4u5aA:
1.8
3m0wH-4u5aA:
1.8		 3m0wE-4u5aA:
19.80
3m0wF-4u5aA:
19.80
3m0wG-4u5aA:
19.80
3m0wH-4u5aA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_I_P77I203_1
(PROTEIN S100-A4)		 4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL
(Plasmodium
berghei) 		5 / 10 LEU A  57
ASP A  60
PHE A 115
ILE A 138
CYH A 142
 None
 1.23A 3m0wA-4u5aA:
1.7
3m0wB-4u5aA:
1.9
3m0wI-4u5aA:
1.8
3m0wJ-4u5aA:
1.9		 3m0wA-4u5aA:
19.80
3m0wB-4u5aA:
19.80
3m0wI-4u5aA:
19.80
3m0wJ-4u5aA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL
(Plasmodium
berghei) 		4 / 7 ILE A  79
VAL A  91
LEU A  94
SER A  95
 None
 0.53A 3r9vA-4u5aA:
undetectable
3r9vB-4u5aA:
3.2		 3r9vA-4u5aA:
23.21
3r9vB-4u5aA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL
(Plasmodium
berghei) 		4 / 7 ASN A 119
GLU A 117
ILE A 116
ASP A  55
 None
 0.94A 4d33B-4u5aA:
undetectable		 4d33B-4u5aA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL
(Plasmodium
berghei) 		4 / 8 ASN A 119
GLU A 117
ILE A 116
ASP A  55
 None
 0.90A 4d39A-4u5aA:
2.5		 4d39A-4u5aA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL
(Plasmodium
berghei) 		4 / 7 ASN A 119
GLU A 117
ILE A 116
ASP A  55
 None
 0.98A 4d39B-4u5aA:
undetectable		 4d39B-4u5aA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL
(Plasmodium
berghei) 		3 / 3 PHE A  61
ASP A  59
ARG A 113
 None
 0.79A 4eahF-4u5aA:
undetectable		 4eahF-4u5aA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL
(Plasmodium
berghei) 		3 / 3 PHE A  61
ASP A  59
ARG A 113
 None
 0.79A 4eahG-4u5aA:
undetectable		 4eahG-4u5aA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL
(Plasmodium
berghei) 		3 / 3 THR A  68
THR A  71
PHE A  76
 None
 0.85A 5cxvA-4u5aA:
3.4		 5cxvA-4u5aA:
17.87