SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u60'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 4u60 STRUCTURAL PROTEIN
VP1
(Human
polyomavirus
8) 		4 / 4 LEU A 296
PRO A 162
ILE A  96
LEU A  98
 None
 1.14A 1ya4C-4u60A:
undetectable		 1ya4C-4u60A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 4u60 STRUCTURAL PROTEIN
VP1
(Human
polyomavirus
8) 		4 / 8 GLY A 257
GLU A 114
ALA A 115
ASN A 223
 EDO  A 406 (-4.5A)
None
None
EDO  A 406 (-4.2A)
 0.75A 2dtjA-4u60A:
undetectable
2dtjB-4u60A:
undetectable		 2dtjA-4u60A:
20.69
2dtjB-4u60A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_2
(GENOME POLYPROTEIN)		 4u60 STRUCTURAL PROTEIN
VP1
(Human
polyomavirus
8) 		4 / 4 PHE A 153
TYR A 226
VAL A 125
LEU A 288
 None
 1.27A 3keeD-4u60A:
undetectable		 3keeD-4u60A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 4u60 STRUCTURAL PROTEIN
VP1
(Human
polyomavirus
8) 		5 / 12 LEU A 163
GLY A 159
GLY A 160
VAL A 267
SER A 268
 None
 1.04A 3nk7A-4u60A:
undetectable		 3nk7A-4u60A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4u60 STRUCTURAL PROTEIN
VP1
(Human
polyomavirus
8) 		5 / 12 TYR A  91
SER A 268
GLY A 207
ALA A 208
CYH A 215
 None
 1.15A 4bupB-4u60A:
undetectable		 4bupB-4u60A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 4u60 STRUCTURAL PROTEIN
VP1
(Human
polyomavirus
8) 		5 / 10 VAL A 211
GLU A 212
LEU A 240
PHE A 275
THR A 236
 None
 1.37A 5mm4B-4u60A:
undetectable		 5mm4B-4u60A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4u60 STRUCTURAL PROTEIN
VP1
(Human
polyomavirus
8) 		5 / 12 TYR A  91
SER A 268
GLY A 207
ALA A 208
CYH A 215
 None
 1.23A 5wbvA-4u60A:
undetectable		 5wbvA-4u60A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4u60 STRUCTURAL PROTEIN
VP1
(Human
polyomavirus
8) 		5 / 12 TYR A  91
SER A 268
GLY A 207
ALA A 208
CYH A 215
 None
 1.22A 5wbvB-4u60A:
undetectable		 5wbvB-4u60A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4u60 STRUCTURAL PROTEIN
VP1
(Human
polyomavirus
8) 		3 / 3 GLN A 193
TYR A 172
ASN A 171
 None
 0.96A 6dwdC-4u60A:
undetectable		 6dwdC-4u60A:
20.38