SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u63'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		3 / 3 ARG A  13
GLY A 106
ASP A 110
 None
 0.26A 1kf6A-4u63A:
undetectable
1kf6B-4u63A:
undetectable		 1kf6A-4u63A:
21.27
1kf6B-4u63A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		3 / 3 ASP A 360
LYS A 366
ARG A 369
 None
 0.88A 1ra8A-4u63A:
undetectable		 1ra8A-4u63A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		5 / 12 ILE A   9
VAL A  96
LEU A 117
VAL A 124
LEU A 113
 None
 1.01A 2aw1A-4u63A:
undetectable		 2aw1A-4u63A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		4 / 7 LEU A 335
PRO A 206
VAL A 373
TRP A  54
 None
SO4  A1015 (-4.3A)
None
None
 1.20A 2hrcA-4u63A:
undetectable		 2hrcA-4u63A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		4 / 6 MET A 341
ILE A 348
ARG A 344
SER A 242
 None
None
None
FAD  A1002 (-3.4A)
 1.48A 2qd3B-4u63A:
4.2		 2qd3B-4u63A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		4 / 8 ASN A 380
SER A 379
TYR A 285
ASN A 343
 FAD  A1002 (-4.1A)
FAD  A1002 (-3.6A)
None
FAD  A1002 (-3.5A)
 1.17A 2wekA-4u63A:
undetectable		 2wekA-4u63A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		4 / 8 ASN A 380
SER A 379
TYR A 285
ASN A 343
 FAD  A1002 (-4.1A)
FAD  A1002 (-3.6A)
None
FAD  A1002 (-3.5A)
 1.20A 2wekB-4u63A:
undetectable		 2wekB-4u63A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		5 / 12 GLY A  92
ALA A  93
ASP A  94
GLY A  32
ILE A   9
 None
None
None
SO4  A1011 (-3.7A)
None
 1.02A 3cyxA-4u63A:
undetectable		 3cyxA-4u63A:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		3 / 3 ILE A 354
PHE A 306
HIS A 356
 None
 0.76A 3h0aA-4u63A:
undetectable		 3h0aA-4u63A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		3 / 3 LEU A  59
ARG A 101
ASN A  21
 None
 0.63A 3qxvD-4u63A:
undetectable		 3qxvD-4u63A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		5 / 11 GLY A 321
ALA A 350
VAL A 328
PRO A 455
ILE A 458
 None
FAD  A1002 ( 3.9A)
None
None
None
 1.10A 4j4vA-4u63A:
undetectable		 4j4vA-4u63A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		5 / 11 GLY A 321
ALA A 350
VAL A 328
PRO A 455
ILE A 458
 None
FAD  A1002 ( 3.9A)
None
None
None
 1.23A 4j4vD-4u63A:
undetectable
4j4vE-4u63A:
undetectable		 4j4vD-4u63A:
22.25
4j4vE-4u63A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		4 / 5 ARG A 125
THR A 123
THR A  95
ASP A  94
 None
 1.05A 4oltA-4u63A:
undetectable		 4oltA-4u63A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		4 / 5 ARG A 125
THR A 123
THR A  95
ASP A  94
 None
 1.06A 4oltB-4u63A:
undetectable		 4oltB-4u63A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		4 / 5 ARG A 125
THR A 123
THR A  95
ASP A  94
 None
 1.06A 4qwpA-4u63A:
undetectable		 4qwpA-4u63A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		4 / 5 ARG A 125
THR A 123
THR A  95
ASP A  94
 None
 1.07A 4qwpB-4u63A:
undetectable		 4qwpB-4u63A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		4 / 5 TYR A 431
LYS A 434
PRO A 435
GLU A 408
 None
 1.22A 4w5tA-4u63A:
3.4		 4w5tA-4u63A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		5 / 11 LEU A  66
LEU A 172
LEU A  18
ALA A  23
LEU A  24
 None
 1.17A 4wg0F-4u63A:
undetectable
4wg0G-4u63A:
undetectable
4wg0H-4u63A:
undetectable		 4wg0F-4u63A:
4.66
4wg0G-4u63A:
4.66
4wg0H-4u63A:
4.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		5 / 11 LEU A  66
LEU A 172
LEU A  18
ALA A  23
LEU A  24
 None
 1.19A 4wg0H-4u63A:
undetectable
4wg0I-4u63A:
undetectable
4wg0J-4u63A:
undetectable		 4wg0H-4u63A:
4.66
4wg0I-4u63A:
4.66
4wg0J-4u63A:
4.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		5 / 11 ALA A  23
LEU A  24
LEU A  18
LEU A  66
LEU A 172
 None
 1.17A 4wg0G-4u63A:
undetectable
4wg0H-4u63A:
undetectable
4wg0I-4u63A:
undetectable		 4wg0G-4u63A:
4.66
4wg0H-4u63A:
4.66
4wg0I-4u63A:
4.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		5 / 11 LEU A  66
LEU A 172
LEU A  18
ALA A  23
LEU A  24
 None
 1.17A 4wg0J-4u63A:
undetectable
4wg0K-4u63A:
undetectable
4wg0L-4u63A:
undetectable		 4wg0J-4u63A:
4.66
4wg0K-4u63A:
4.66
4wg0L-4u63A:
4.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		5 / 11 ALA A  23
LEU A  24
LEU A  18
LEU A  66
LEU A 172
 None
 1.14A 4wg0I-4u63A:
undetectable
4wg0J-4u63A:
undetectable
4wg0K-4u63A:
undetectable		 4wg0I-4u63A:
4.66
4wg0J-4u63A:
4.66
4wg0K-4u63A:
4.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		5 / 11 ALA A  23
LEU A  24
LEU A  18
LEU A  66
LEU A 172
 None
 1.15A 4wg0K-4u63A:
undetectable
4wg0L-4u63A:
undetectable
4wg0M-4u63A:
undetectable		 4wg0K-4u63A:
4.66
4wg0L-4u63A:
4.66
4wg0M-4u63A:
4.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		4 / 6 TYR A 431
LYS A 434
PRO A 435
GLU A 408
 None
 1.26A 4z4cA-4u63A:
4.0		 4z4cA-4u63A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QJQ_A_K1SA304_0
(ADP-SUGAR
PYROPHOSPHATASE)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		4 / 5 TRP A  11
TRP A  98
VAL A  97
LEU A 117
 None
 1.39A 5qjqA-4u63A:
0.0
5qjqB-4u63A:
0.0		 5qjqA-4u63A:
18.48
5qjqB-4u63A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QJQ_B_K1SB304_0
(ADP-SUGAR
PYROPHOSPHATASE)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		4 / 5 TRP A  98
VAL A  97
LEU A 117
TRP A  11
 None
 1.36A 5qjqA-4u63A:
0.0
5qjqB-4u63A:
0.0		 5qjqA-4u63A:
18.48
5qjqB-4u63A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		5 / 12 LEU A  87
ARG A  82
LEU A  84
ILE A  39
ALA A  76
 None
SO4  A1014 (-3.5A)
None
None
None
 1.11A 5v0vA-4u63A:
undetectable		 5v0vA-4u63A:
23.78