SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u65'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4u65 PUTATIVE CYSTINE
PROTEASE
(Pseudomonas
fluorescens) 		5 / 12 ALA E 141
LEU E 128
PHE E 101
GLN E  86
ASN E  81
 None
 0.89A 1u72A-4u65E:
undetectable		 1u72A-4u65E:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 4u65 TWO COMPONENT
HISTIDINE KINASE,
GGDEF DOMAIN
PROTEIN/EAL DOMAIN
PROTEIN
(Legionella
pneumophila) 		4 / 5 ILE A  58
SER A 120
LEU A  53
ASN A  59
 None
 1.19A 1y0xX-4u65A:
undetectable		 1y0xX-4u65A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 4u65 PUTATIVE CYSTINE
PROTEASE
(Pseudomonas
fluorescens) 		5 / 12 ALA E 141
LEU E 128
PHE E 101
GLN E  86
ASN E  81
 None
 0.92A 2w3mB-4u65E:
undetectable		 2w3mB-4u65E:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 4u65 PUTATIVE CYSTINE
PROTEASE
(Pseudomonas
fluorescens) 		3 / 3 HIS E 148
PHE E 101
PHE E 102
 None
 0.66A 3lk0D-4u65E:
undetectable		 3lk0D-4u65E:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4u65 TWO COMPONENT
HISTIDINE KINASE,
GGDEF DOMAIN
PROTEIN/EAL DOMAIN
PROTEIN
(Legionella
pneumophila) 		4 / 6 TYR A 142
MET A  27
ILE A 111
SER A 101
 None
 1.16A 3pmzD-4u65A:
undetectable		 3pmzD-4u65A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4u65 PUTATIVE CYSTINE
PROTEASE
(Pseudomonas
fluorescens) 		5 / 12 ALA E 141
LEU E 128
PHE E 101
GLN E  86
ASN E  81
 None
 0.89A 4kebB-4u65E:
undetectable		 4kebB-4u65E:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 4u65 TWO COMPONENT
HISTIDINE KINASE,
GGDEF DOMAIN
PROTEIN/EAL DOMAIN
PROTEIN
(Legionella
pneumophila) 		5 / 11 LEU A  53
ASN A  59
GLY A  88
VAL A 132
ILE A 122
 None
 1.27A 5kr2B-4u65A:
undetectable		 5kr2B-4u65A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4u65 PUTATIVE CYSTINE
PROTEASE
(Pseudomonas
fluorescens) 		3 / 3 SER E 177
TYR E 176
TYR E 175
 None
 0.72A 5lakA-4u65E:
undetectable
5lakI-4u65E:
undetectable		 5lakA-4u65E:
18.93
5lakI-4u65E:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4u65 PUTATIVE CYSTINE
PROTEASE
(Pseudomonas
fluorescens) 		3 / 3 SER E 177
TYR E 176
TYR E 175
 None
 0.72A 5lakC-4u65E:
undetectable
5lakJ-4u65E:
undetectable		 5lakC-4u65E:
18.93
5lakJ-4u65E:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4u65 PUTATIVE CYSTINE
PROTEASE
(Pseudomonas
fluorescens) 		4 / 6 LEU E  65
ILE E 140
THR E 123
TRP E 233
 None
 1.41A 5ljeA-4u65E:
undetectable		 5ljeA-4u65E:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_A_ACTA301_0
(ANTIBODY FAB HEAVY
CHAIN)		 4u65 PUTATIVE CYSTINE
PROTEASE
(Pseudomonas
fluorescens) 		4 / 4 THR E 174
VAL E 172
PRO E 204
THR E 159
 None
 1.17A 5mthA-4u65E:
undetectable
5mthH-4u65E:
undetectable		 5mthA-4u65E:
21.03
5mthH-4u65E:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4u65 PUTATIVE CYSTINE
PROTEASE
(Pseudomonas
fluorescens) 		5 / 12 GLU E 211
SER E 153
PHE E 144
ARG E 232
LEU E 237
 None
 1.33A 5nd4B-4u65E:
undetectable		 5nd4B-4u65E:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 4u65 PUTATIVE CYSTINE
PROTEASE
(Pseudomonas
fluorescens) 		3 / 3 TRP E  79
ILE E 125
GLU E 122
 None
 0.79A 6hcxA-4u65E:
undetectable		 6hcxA-4u65E:
17.17