SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u66'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 4u66 PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Alkaliphilus
oremlandii) 		5 / 12 LEU A 148
LEU A 142
LEU A 167
LEU A 202
MET A 188
 None
None
SO4  A 301 (-4.1A)
None
None
 1.28A 3d90B-4u66A:
undetectable		 3d90B-4u66A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4u66 PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Alkaliphilus
oremlandii) 		4 / 7 ILE A  57
GLY A  25
TYR A 141
LEU A  78
 None
 0.84A 3elzA-4u66A:
undetectable		 3elzA-4u66A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 4u66 PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Alkaliphilus
oremlandii) 		4 / 7 ASP A  21
PHE A  17
GLY A  36
THR A  33
 None
 1.12A 3vnsA-4u66A:
2.7		 3vnsA-4u66A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u66 PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Alkaliphilus
oremlandii) 		4 / 8 ASN A 116
GLU A 113
ILE A 112
ASN A  80
 None
 1.07A 4d33A-4u66A:
undetectable		 4d33A-4u66A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u66 PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Alkaliphilus
oremlandii) 		4 / 7 ASN A 116
GLU A 113
ILE A 112
ASN A  80
 None
 1.12A 4d33B-4u66A:
undetectable		 4d33B-4u66A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4u66 PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Alkaliphilus
oremlandii) 		4 / 7 ASN A 116
GLU A 113
ILE A 112
ASN A  80
 None
 1.06A 4d39B-4u66A:
undetectable		 4d39B-4u66A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4u66 PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Alkaliphilus
oremlandii) 		5 / 12 THR A  33
LYS A 139
ALA A 169
GLY A  25
ALA A  22
 None
 1.33A 5l5zH-4u66A:
undetectable
5l5zI-4u66A:
undetectable		 5l5zH-4u66A:
21.54
5l5zI-4u66A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4u66 PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Alkaliphilus
oremlandii) 		5 / 12 THR A  33
LYS A 139
ALA A 169
GLY A  25
ALA A  22
 None
 1.33A 5l5zV-4u66A:
undetectable
5l5zW-4u66A:
undetectable		 5l5zV-4u66A:
21.54
5l5zW-4u66A:
18.78