SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u6b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 4u6b CONSERVED
HYPOTHETICAL
LIPOPROTEIN
(Zobellia
galactanivorans) 		5 / 10 ASP A 147
ASP A 139
ALA A 200
ASN A 202
TRP A 179
 None
PEG  A 504 (-3.9A)
None
None
None
 1.40A 1fpqA-4u6bA:
undetectable		 1fpqA-4u6bA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4u6b CONSERVED
HYPOTHETICAL
LIPOPROTEIN
(Zobellia
galactanivorans) 		4 / 8 ASP A 249
LYS A 264
GLY A 282
TYR A 262
 PEG  A 503 (-3.9A)
PEG  A 503 (-3.1A)
None
None
 0.93A 2aouA-4u6bA:
undetectable		 2aouA-4u6bA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_2
(RENIN)		 4u6b CONSERVED
HYPOTHETICAL
LIPOPROTEIN
(Zobellia
galactanivorans) 		4 / 4 VAL A 233
TYR A 195
PRO A 252
PHE A 293
 None
 1.50A 3d91B-4u6bA:
undetectable		 3d91B-4u6bA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 4u6b CONSERVED
HYPOTHETICAL
LIPOPROTEIN
(Zobellia
galactanivorans) 		4 / 8 TYR A 333
GLU A 315
PHE A 340
ILE A 342
 None
 0.85A 3jz0B-4u6bA:
undetectable		 3jz0B-4u6bA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 4u6b CONSERVED
HYPOTHETICAL
LIPOPROTEIN
(Zobellia
galactanivorans) 		4 / 6 ILE A 322
LEU A 320
LYS A  84
PHE A  83
 None
 1.05A 3sj1X-4u6bA:
undetectable		 3sj1X-4u6bA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 4u6b CONSERVED
HYPOTHETICAL
LIPOPROTEIN
(Zobellia
galactanivorans) 		4 / 5 ASP A 245
GLY A 237
ASP A 243
THR A 247
 None
 1.25A 3vqrB-4u6bA:
undetectable		 3vqrB-4u6bA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 4u6b CONSERVED
HYPOTHETICAL
LIPOPROTEIN
(Zobellia
galactanivorans) 		4 / 4 TRP A 372
LEU A 374
LEU A  88
THR A 160
 None
 1.46A 4bboD-4u6bA:
undetectable		 4bboD-4u6bA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 4u6b CONSERVED
HYPOTHETICAL
LIPOPROTEIN
(Zobellia
galactanivorans) 		4 / 8 SER A 181
LEU A 148
CYH A 149
PRO A 204
 None
None
None
PEG  A 504 ( 4.8A)
 1.07A 4j7uD-4u6bA:
undetectable		 4j7uD-4u6bA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 4u6b CONSERVED
HYPOTHETICAL
LIPOPROTEIN
(Zobellia
galactanivorans) 		5 / 12 SER A 181
LEU A 148
CYH A 149
PRO A 204
GLY A 130
 None
None
None
PEG  A 504 ( 4.8A)
None
 1.11A 4j7xA-4u6bA:
undetectable		 4j7xA-4u6bA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 4u6b CONSERVED
HYPOTHETICAL
LIPOPROTEIN
(Zobellia
galactanivorans) 		5 / 12 SER A 181
LEU A 148
CYH A 149
PRO A 204
GLY A 130
 None
None
None
PEG  A 504 ( 4.8A)
None
 1.12A 4j7xB-4u6bA:
undetectable		 4j7xB-4u6bA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 4u6b CONSERVED
HYPOTHETICAL
LIPOPROTEIN
(Zobellia
galactanivorans) 		5 / 12 SER A 181
LEU A 148
CYH A 149
PRO A 204
GLY A 130
 None
None
None
PEG  A 504 ( 4.8A)
None
 1.10A 4j7xF-4u6bA:
undetectable		 4j7xF-4u6bA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D6T_D_FYPD406_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
HUMAN GABA-A
RECEPTOR SUBUNIT
GAMMA-2)		 4u6b CONSERVED
HYPOTHETICAL
LIPOPROTEIN
(Zobellia
galactanivorans) 		5 / 11 SER A 389
THR A 378
ASP A 104
ALA A 352
THR A 351
 None
None
PEG  A 503 (-3.2A)
CA  A 502 ( 4.8A)
None
 1.47A 6d6tD-4u6bA:
0.0
6d6tE-4u6bA:
undetectable		 6d6tD-4u6bA:
23.94
6d6tE-4u6bA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 4u6b CONSERVED
HYPOTHETICAL
LIPOPROTEIN
(Zobellia
galactanivorans) 		3 / 3 ARG A 103
ARG A 122
ASP A 145
 PEG  A 503 (-4.3A)
None
None
 0.58A 6d8pA-4u6bA:
undetectable		 6d8pA-4u6bA:
20.02