SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u6d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN
(Zobellia
galactanivorans) 		5 / 12 THR A 342
GLY A 347
GLY A 345
ALA A 296
VAL A 335
 EDO  A 511 (-4.1A)
None
None
None
None
 1.09A 2yvlD-4u6dA:
undetectable		 2yvlD-4u6dA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_2
(RENIN)		 4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN
(Zobellia
galactanivorans) 		4 / 4 VAL A 215
TYR A 177
PRO A 234
PHE A 271
 None
EDO  A 512 ( 4.9A)
None
None
 1.45A 3d91B-4u6dA:
undetectable		 3d91B-4u6dA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN
(Zobellia
galactanivorans) 		4 / 8 TYR A 180
VAL A 164
VAL A 149
TRP A 208
 None
 0.83A 3hjoA-4u6dA:
undetectable		 3hjoA-4u6dA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN
(Zobellia
galactanivorans) 		5 / 9 TYR A  70
GLY A 351
ALA A 331
THR A 287
ILE A 300
 EDO  A 520 (-4.3A)
None
None
None
None
 1.40A 3jusB-4u6dA:
undetectable		 3jusB-4u6dA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN
(Zobellia
galactanivorans) 		3 / 3 ARG A 370
THR A 356
THR A 287
 EDO  A 505 (-2.6A)
PEG  A 503 (-2.8A)
None
 0.77A 3k2hB-4u6dA:
undetectable		 3k2hB-4u6dA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN
(Zobellia
galactanivorans) 		4 / 7 ASP A 231
GLN A 259
TYR A 233
PRO A 232
 3DY  A 521 (-2.6A)
None
None
None
 1.20A 3l2vA-4u6dA:
undetectable		 3l2vA-4u6dA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN
(Zobellia
galactanivorans) 		4 / 8 TYR A  65
GLU A 325
LEU A 375
PHE A  68
 None
 1.00A 3rqwC-4u6dA:
undetectable
3rqwD-4u6dA:
undetectable		 3rqwC-4u6dA:
20.61
3rqwD-4u6dA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN
(Zobellia
galactanivorans) 		4 / 8 GLU A 325
LEU A 375
PHE A  68
TYR A  65
 None
 1.01A 3rqwF-4u6dA:
undetectable
3rqwJ-4u6dA:
undetectable		 3rqwF-4u6dA:
20.61
3rqwJ-4u6dA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN
(Zobellia
galactanivorans) 		4 / 5 GLY A  83
THR A  84
HIS A 365
GLY A  80
 None
None
None
EDO  A 514 (-4.0A)
 1.19A 4v20A-4u6dA:
undetectable		 4v20A-4u6dA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN
(Zobellia
galactanivorans) 		4 / 6 ASN A 120
THR A 109
PRO A 110
THR A 111
 None
 0.83A 4yoaA-4u6dA:
undetectable		 4yoaA-4u6dA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN
(Zobellia
galactanivorans) 		3 / 3 ILE A 216
PRO A 217
ILE A 229
 None
 0.44A 5hw8F-4u6dA:
undetectable		 5hw8F-4u6dA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN
(Zobellia
galactanivorans) 		5 / 9 GLY A 283
VAL A 299
ALA A 297
LEU A 288
VAL A 279
 None
 1.08A 5lw1H-4u6dA:
undetectable		 5lw1H-4u6dA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHD_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN
(Zobellia
galactanivorans) 		5 / 12 LEU A 368
SER A  86
PRO A 113
ASN A 364
HIS A 230
 None
None
None
None
3DY  A 521 ( 3.7A)
 1.49A 5uhdC-4u6dA:
0.7		 5uhdC-4u6dA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN
(Zobellia
galactanivorans) 		3 / 3 GLY A 182
THR A 287
PRO A 232
 None
 0.58A 5v5zA-4u6dA:
undetectable		 5v5zA-4u6dA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN
(Zobellia
galactanivorans) 		3 / 3 ARG A  88
ARG A 107
ASP A 127
 3DY  A 521 (-4.0A)
None
None
 0.60A 6d8pA-4u6dA:
undetectable		 6d8pA-4u6dA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN
(Zobellia
galactanivorans) 		3 / 3 ASN A 218
PRO A 195
GLN A 181
 None
None
3DY  A 521 (-3.2A)
 0.59A 6jnhA-4u6dA:
undetectable		 6jnhA-4u6dA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN
(Zobellia
galactanivorans) 		3 / 3 ASN A 218
PRO A 195
GLN A 181
 None
None
3DY  A 521 (-3.2A)
 0.58A 6jogA-4u6dA:
undetectable		 6jogA-4u6dA:
16.43