SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u6h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_D_TPFD2473_1
(CYTOCHROME P450 121)		 4u6h HEAVY CHAIN OF
MURINE ANTI-VACCINIA
L1 IGG2A ANTIBODY
M12B9
PROTEIN L1
(Mus
musculus;
Vaccinia
virus) 		5 / 10 VAL E  68
ASN E 157
THR E 151
ALA E  61
SER A  54
 None
 1.35A 2ij7D-4u6hE:
undetectable		 2ij7D-4u6hE:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 4u6h HEAVY CHAIN OF
MURINE ANTI-VACCINIA
L1 IGG2A ANTIBODY
M12B9
(Mus
musculus) 		3 / 3 GLY A  49
GLU A  59
THR A  58
 None
 0.46A 4kouA-4u6hA:
undetectable		 4kouA-4u6hA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4u6h PROTEIN L1
(Vaccinia
virus) 		5 / 9 THR E  75
LEU E  14
ALA E  72
GLN E 165
THR E 167
 None
 1.23A 4ltwA-4u6hE:
undetectable		 4ltwA-4u6hE:
19.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 4u6h HEAVY CHAIN OF
MURINE ANTI-VACCINIA
L1 IGG2A ANTIBODY
M12B9
(Mus
musculus) 		4 / 5 VAL A   2
TYR A  27
ARG A  98
TYR A 108
 None
 0.28A 4m7kH-4u6hA:
27.2		 4m7kH-4u6hA:
66.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4u6h PROTEIN L1
(Vaccinia
virus) 		4 / 5 THR E 167
THR E 168
THR E  52
ASN E  12
 None
 1.19A 4pgfB-4u6hE:
undetectable		 4pgfB-4u6hE:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4u6h HEAVY CHAIN OF
MURINE ANTI-VACCINIA
L1 IGG2A ANTIBODY
M12B9
PROTEIN L1
(Mus
musculus;
Vaccinia
virus) 		4 / 5 GLY E 152
TYR A  50
TYR A  57
GLY A  56
 None
 0.79A 5ayfA-4u6hE:
undetectable		 5ayfA-4u6hE:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 4u6h HEAVY CHAIN OF
MURINE ANTI-VACCINIA
L1 IGG2A ANTIBODY
M12B9
(Mus
musculus) 		5 / 12 ALA A  16
PHE A 152
TYR A 151
LEU A 114
THR A  87
 None
 1.10A 5tl8A-4u6hA:
undetectable		 5tl8A-4u6hA:
17.09