SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u6u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 4u6u COG5
(Kluyveromyces
lactis) 		4 / 8 PHE B 333
SER B 351
ILE B 354
LEU B 385
 None
 0.86A 1eupA-4u6uB:
0.0		 1eupA-4u6uB:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4u6u COG5
(Kluyveromyces
lactis) 		5 / 11 ALA B 279
PHE B 329
LYS B 330
ILE B 354
THR B 258
 None
 1.18A 1jomA-4u6uB:
undetectable		 1jomA-4u6uB:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4u6u COG5
(Kluyveromyces
lactis) 		5 / 12 ALA B 279
PHE B 329
LYS B 330
ILE B 354
THR B 258
 None
 1.25A 1re7B-4u6uB:
undetectable		 1re7B-4u6uB:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 4u6u COG5
COG7
(Kluyveromyces
lactis) 		3 / 3 LEU A  30
LEU B 130
MET A  53
 None
 0.63A 1ya3B-4u6uA:
undetectable		 1ya3B-4u6uA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 4u6u COG5
COG7
(Kluyveromyces
lactis) 		4 / 5 LEU A  39
LEU B 187
CYH A  46
THR A  44
 None
 1.41A 2oaxD-4u6uA:
undetectable		 2oaxD-4u6uA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 4u6u COG5
(Kluyveromyces
lactis) 		4 / 6 LEU B 211
LEU B 207
ILE B 228
ARG B 227
 None
 1.07A 2rlfB-4u6uB:
undetectable
2rlfC-4u6uB:
undetectable		 2rlfB-4u6uB:
10.60
2rlfC-4u6uB:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 4u6u COG5
(Kluyveromyces
lactis) 		4 / 4 PHE B 329
LYS B 330
ILE B 266
THR B 258
 None
 1.23A 3ia4B-4u6uB:
undetectable		 3ia4B-4u6uB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 4u6u COG5
(Kluyveromyces
lactis) 		4 / 5 THR B 184
ILE B 188
LYS B 189
GLU B 192
 None
 1.38A 4ac9C-4u6uB:
undetectable		 4ac9C-4u6uB:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4u6u COG5
(Kluyveromyces
lactis) 		4 / 5 THR B 184
ILE B 188
LYS B 189
GLU B 192
 None
 1.36A 4acaC-4u6uB:
undetectable		 4acaC-4u6uB:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4u6u COG5
(Kluyveromyces
lactis) 		4 / 5 THR B 184
ILE B 188
LYS B 189
GLU B 192
 None
 1.35A 4acbC-4u6uB:
undetectable		 4acbC-4u6uB:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4u6u COG5
COG7
(Kluyveromyces
lactis) 		4 / 6 LEU A  49
LEU A  30
ILE A  29
THR B 127
 None
 1.00A 4do3B-4u6uA:
undetectable		 4do3B-4u6uA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 4u6u COG5
COG7
(Kluyveromyces
lactis) 		5 / 11 LEU A  31
VAL B 138
LEU B 135
LEU B 187
LEU B 131
 None
 1.26A 4or0B-4u6uA:
undetectable		 4or0B-4u6uA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4u6u COG5
(Kluyveromyces
lactis) 		5 / 11 PHE B 329
LYS B 330
ILE B 354
ILE B 266
THR B 258
 None
 1.36A 4p68A-4u6uB:
undetectable		 4p68A-4u6uB:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 4u6u COG5
(Kluyveromyces
lactis) 		4 / 6 THR B 230
ALA B 234
LEU B 238
SER B 239
 None
 0.97A 4pwjA-4u6uB:
undetectable		 4pwjA-4u6uB:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4u6u COG5
(Kluyveromyces
lactis) 		5 / 12 ALA B 279
PHE B 329
LYS B 330
ILE B 354
THR B 258
 None
 1.18A 4rgcA-4u6uB:
undetectable		 4rgcA-4u6uB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4u6u COG5
(Kluyveromyces
lactis) 		4 / 8 SER B 253
SER B 252
ALA B 259
SER B 328
 None
 1.10A 5l5fY-4u6uB:
undetectable
5l5fZ-4u6uB:
undetectable		 5l5fY-4u6uB:
25.00
5l5fZ-4u6uB:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 4u6u COG5
(Kluyveromyces
lactis) 		4 / 7 THR B 184
LEU B 185
VAL B 138
TYR B 137
 None
 1.07A 5ov9A-4u6uB:
undetectable		 5ov9A-4u6uB:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 4u6u COG5
(Kluyveromyces
lactis) 		4 / 8 ILE B 247
ASN B 218
LEU B 317
LEU B 287
 None
 0.80A 5y7pE-4u6uB:
undetectable		 5y7pE-4u6uB:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4u6u COG5
(Kluyveromyces
lactis) 		5 / 12 ALA B 279
PHE B 329
LYS B 330
ILE B 354
THR B 258
 None
 1.19A 5z6fA-4u6uB:
undetectable		 5z6fA-4u6uB:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4u6u COG5
(Kluyveromyces
lactis) 		3 / 3 PHE B 244
ARG B 312
GLN B 311
 None
 1.16A 6g1pB-4u6uB:
undetectable		 6g1pB-4u6uB:
21.07