SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u6v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4u6v FAB, ANTIGEN BINDING
FRAGMENT, HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 HIS H  32
GLY H  52
TYR H  58
GLY H  50
ASP H  98
 None
 1.25A 4blvB-4u6vH:
undetectable		 4blvB-4u6vH:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4u6v FAB, ANTIGEN BINDING
FRAGMENT, HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 SER H 101
TYR H 100
TYR H 107
 None
 0.85A 5lakC-4u6vH:
undetectable
5lakJ-4u6vH:
undetectable		 5lakC-4u6vH:
22.29
5lakJ-4u6vH:
2.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 4u6v FAB, ANTIGEN BINDING
FRAGMENT, HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 TYR H  59
GLY H  65
THR H  68
 SO4  H 301 (-4.3A)
None
None
 0.14A 6cjkB-4u6vH:
24.0		 6cjkB-4u6vH:
60.87