SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u7b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 4u7b MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		4 / 4 LEU A 329
PRO A 330
LEU A 149
ARG A 151
 None
 1.36A 2hrcA-4u7bA:
undetectable		 2hrcA-4u7bA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 4u7b MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		4 / 6 SER A 305
PHE A 300
ASP A 301
GLU A 312
 None
 0.96A 2vn1B-4u7bA:
undetectable		 2vn1B-4u7bA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4u7b MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		4 / 4 LEU A 329
PRO A 330
LEU A 149
ARG A 151
 None
 1.35A 3hcoB-4u7bA:
undetectable		 3hcoB-4u7bA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4u7b MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		4 / 4 PRO A 272
LEU A 271
ILE A 245
ARG A 151
 None
 1.45A 4f4dA-4u7bA:
undetectable		 4f4dA-4u7bA:
21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 4u7b MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		4 / 6 ASP A 156
ALA A 275
TYR A 276
ASP A 284
 None
 0.36A 4mdaA-4u7bA:
31.7		 4mdaA-4u7bA:
99.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 4u7b MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		5 / 6 ASP A 156
ASN A 250
ALA A 275
TYR A 276
ASP A 284
 None
 0.38A 4mdbA-4u7bA:
31.4		 4mdbA-4u7bA:
99.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 4u7b MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		4 / 6 ASP A 284
ASN A 250
ALA A 275
TYR A 276
 None
 0.92A 4mdbA-4u7bA:
31.4		 4mdbA-4u7bA:
99.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4u7b MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		5 / 9 LEU A 263
HIS A 254
ASN A 250
VAL A 270
LEU A 247
 None
 1.06A 4qd3A-4u7bA:
undetectable		 4qd3A-4u7bA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 4u7b MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		4 / 6 ARG A 132
ARG A 332
ASP A 279
VAL A 337
 None
 1.37A 4xqeA-4u7bA:
undetectable		 4xqeA-4u7bA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 4u7b MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		4 / 6 ARG A 132
ARG A 332
ASP A 279
VAL A 337
 None
 1.40A 4xqeB-4u7bA:
undetectable		 4xqeB-4u7bA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 4u7b MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		4 / 7 ARG A 142
LEU A 139
ILE A 326
LEU A 329
 None
 0.92A 5te8A-4u7bA:
undetectable		 5te8A-4u7bA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 4u7b MARINER MOS1
TRANSPOSASE
(Drosophila
mauritiana) 		4 / 7 LEU A 280
ALA A 274
ILE A 138
LEU A 139
 None
 1.04A 5te8A-4u7bA:
undetectable		 5te8A-4u7bA:
22.02