SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u7d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 4u7d ATP-DEPENDENT DNA
HELICASE Q1
(Homo
sapiens) 		4 / 7 LEU A 579
TYR A 554
HIS A 584
ASN A 488
 None
 1.00A 1afsA-4u7dA:
undetectable		 1afsA-4u7dA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 4u7d ATP-DEPENDENT DNA
HELICASE Q1
(Homo
sapiens) 		4 / 7 LEU A 579
TYR A 554
HIS A 584
ASN A 488
 None
 1.01A 1afsB-4u7dA:
undetectable		 1afsB-4u7dA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 4u7d ATP-DEPENDENT DNA
HELICASE Q1
(Homo
sapiens) 		5 / 12 ALA A 257
LEU A 111
PHE A 110
LEU A 250
ALA A 265
 None
 1.06A 1bzfA-4u7dA:
undetectable		 1bzfA-4u7dA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4u7d ATP-DEPENDENT DNA
HELICASE Q1
(Homo
sapiens) 		5 / 12 GLY A 317
ILE A 387
GLY A 403
ALA A 412
LEU A 286
 None
 0.89A 1jg2A-4u7dA:
4.1		 1jg2A-4u7dA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4u7d ATP-DEPENDENT DNA
HELICASE Q1
(Homo
sapiens) 		4 / 6 LEU A  97
LEU A 121
ILE A  82
GLU A  71
 None
 0.97A 1mt1A-4u7dA:
undetectable
1mt1F-4u7dA:
undetectable		 1mt1A-4u7dA:
6.93
1mt1F-4u7dA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4u7d ATP-DEPENDENT DNA
HELICASE Q1
(Homo
sapiens) 		4 / 6 ILE A  82
GLU A  71
LEU A  97
LEU A 121
 None
 1.01A 1mt1B-4u7dA:
undetectable
1mt1C-4u7dA:
undetectable		 1mt1B-4u7dA:
12.05
1mt1C-4u7dA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4u7d ATP-DEPENDENT DNA
HELICASE Q1
(Homo
sapiens) 		4 / 7 LEU A  97
LEU A 121
ILE A  82
GLU A  71
 None
 1.04A 1n13I-4u7dA:
undetectable
1n13L-4u7dA:
undetectable		 1n13I-4u7dA:
6.93
1n13L-4u7dA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4u7d ATP-DEPENDENT DNA
HELICASE Q1
(Homo
sapiens) 		3 / 3 ARG A 215
VAL A  79
TRP A  75
 None
 1.28A 1vagA-4u7dA:
undetectable		 1vagA-4u7dA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 4u7d ATP-DEPENDENT DNA
HELICASE Q1
(Homo
sapiens) 		5 / 9 ILE A 304
ILE A 301
VAL A 330
THR A 331
ALA A 341
 None
 1.05A 2m9qA-4u7dA:
undetectable		 2m9qA-4u7dA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_C_C2FC401_0
(AMINOMETHYLTRANSFERA
SE)		 4u7d ATP-DEPENDENT DNA
HELICASE Q1
(Homo
sapiens) 		5 / 12 ILE A 318
TYR A 320
VAL A 386
PHE A 374
ARG A 283
 None
 1.41A 3a8iC-4u7dA:
undetectable		 3a8iC-4u7dA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_D_C2FD401_0
(AMINOMETHYLTRANSFERA
SE)		 4u7d ATP-DEPENDENT DNA
HELICASE Q1
(Homo
sapiens) 		5 / 12 ILE A 318
TYR A 320
VAL A 386
PHE A 374
ARG A 283
 None
 1.39A 3a8iD-4u7dA:
undetectable		 3a8iD-4u7dA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4u7d ATP-DEPENDENT DNA
HELICASE Q1
(Homo
sapiens) 		4 / 7 PHE A 424
ILE A 551
VAL A 444
TYR A 418
 None
 0.97A 3p6hA-4u7dA:
undetectable		 3p6hA-4u7dA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 4u7d ATP-DEPENDENT DNA
HELICASE Q1
(Homo
sapiens) 		5 / 10 GLY A 573
ALA A 576
ILE A 497
ILE A 499
LEU A 515
 None
 1.08A 4dt8B-4u7dA:
undetectable		 4dt8B-4u7dA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4u7d ATP-DEPENDENT DNA
HELICASE Q1
(Homo
sapiens) 		3 / 3 ASN A 363
ASP A 382
ASP A 379
 None
 0.87A 4obwD-4u7dA:
undetectable		 4obwD-4u7dA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4u7d ATP-DEPENDENT DNA
HELICASE Q1
(Homo
sapiens) 		4 / 4 GLY A 252
VAL A 109
PHE A  92
ILE A 100
 None
 1.03A 4xv2B-4u7dA:
undetectable		 4xv2B-4u7dA:
20.07