SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u7l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1BZF_A_TMQA170_1 (DIHYDROFOLATE REDUCTASE)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	5 / 12	LEU A 138 LEU A 155 THR A 190 PHE A 191 LEU A 200	None	1.05A	1bzfA-4u7lA: undetectable	1bzfA-4u7lA: 16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CMC_B_SAMB105_0 (MET REPRESSOR)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	5 / 10	LEU A 224 LEU A 210 ALA A 214 PHE A 191 GLY A 188	None	1.40A	1cmcA-4u7lA: undetectable 1cmcB-4u7lA: undetectable	1cmcA-4u7lA: 11.36 1cmcB-4u7lA: 11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FBM_B_RTLB951_1 (PROTEIN (CARTILAGE OLIGOMERIC MATRIX PROTEIN))	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	4 / 4	THR A 30 LEU A 54 VAL A 57 LEU A 80	None	1.03A	1fbmB-4u7lA: undetectable	1fbmB-4u7lA: 8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HRK_A_CHDA1501_0 (FERROCHELATASE)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	5 / 12	LEU A 371 LEU A 392 MET A 389 VAL A 381 TRP A 410	None	1.21A	1hrkA-4u7lA: undetectable	1hrkA-4u7lA: 23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HRK_B_CHDB2501_0 (FERROCHELATASE)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	5 / 12	LEU A 347 LEU A 368 ILE A 327 ARG A 418 VAL A 357	None	1.42A	1hrkB-4u7lA: undetectable	1hrkB-4u7lA: 23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HRK_B_CHDB2501_0 (FERROCHELATASE)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	5 / 12	LEU A 371 LEU A 392 MET A 389 ILE A 354 TRP A 410	None	1.33A	1hrkB-4u7lA: undetectable	1hrkB-4u7lA: 23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HRK_B_CHDB2501_0 (FERROCHELATASE)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	5 / 12	LEU A 371 LEU A 392 MET A 389 VAL A 381 TRP A 410	None	1.16A	1hrkB-4u7lA: undetectable	1hrkB-4u7lA: 23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJQ_C_SAMC199_0 (METHIONINE REPRESSOR)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	5 / 10	LEU A 224 LEU A 210 ALA A 214 PHE A 191 GLY A 188	None	1.39A	1mjqC-4u7lA: undetectable 1mjqD-4u7lA: undetectable	1mjqC-4u7lA: 11.58 1mjqD-4u7lA: 11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NT6_A_DVAA6_0 (GRAMICIDIN C)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	3 / 3	ALA A 358 VAL A 381 TRP A 410	None	0.86A	1nt6A-4u7lA: undetectable	1nt6A-4u7lA: 3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NT6_B_DVAB6_0 (GRAMICIDIN C)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	3 / 3	ALA A 358 VAL A 381 TRP A 410	None	0.86A	1nt6B-4u7lA: undetectable	1nt6B-4u7lA: 3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TW4_A_CHDA131_0 (FATTY ACID-BINDING PROTEIN)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	5 / 11	LEU A 293 ASN A 325 ILE A 303 LEU A 282 PHE A 311	None	1.38A	1tw4A-4u7lA: undetectable	1tw4A-4u7lA: 15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TW4_A_CHDA131_0 (FATTY ACID-BINDING PROTEIN)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	5 / 11	LEU A 341 ASN A 325 ILE A 303 LEU A 282 THR A 330	None	1.24A	1tw4A-4u7lA: undetectable	1tw4A-4u7lA: 15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TW4_B_CHDB1131_0 (FATTY ACID-BINDING PROTEIN)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	5 / 10	LEU A 344 ASN A 325 ILE A 303 THR A 330 PHE A 338	None	1.47A	1tw4B-4u7lA: undetectable	1tw4B-4u7lA: 15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1U18_B_HSMB402_1 (NITROPHORIN 1)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	4 / 5	GLU A 49 THR A 30 LEU A 54 LEU A 26	None	1.14A	1u18B-4u7lA: undetectable	1u18B-4u7lA: 16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XDK_B_9CRB600_1 (RETINOIC ACID RECEPTOR, BETA)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	5 / 12	ALA A 142 LEU A 128 ILE A 125 LEU A 95 LEU A 130	None	1.21A	1xdkB-4u7lA: undetectable	1xdkB-4u7lA: 22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HDN_B_TACB1888_1 (ELONGATION FACTOR EF-TU)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	4 / 5	THR A 348 SER A 299 ASP A 323 SER A 275	None	1.07A	2hdnA-4u7lA: undetectable 2hdnB-4u7lA: undetectable 2hdnD-4u7lA: undetectable	2hdnA-4u7lA: 6.58 2hdnB-4u7lA: 20.17 2hdnD-4u7lA: 20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HDN_D_TACD2888_1 (ELONGATION FACTOR EF-TU)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	4 / 5	SER A 275 THR A 348 SER A 299 ASP A 323	None	1.13A	2hdnB-4u7lA: undetectable 2hdnC-4u7lA: undetectable 2hdnD-4u7lA: undetectable	2hdnB-4u7lA: 20.17 2hdnC-4u7lA: 6.58 2hdnD-4u7lA: 20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HRC_B_CHDB1605_0 (FERROCHELATASE)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	5 / 12	LEU A 371 LEU A 392 MET A 389 VAL A 381 TRP A 410	None	1.15A	2hrcB-4u7lA: undetectable	2hrcB-4u7lA: 23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IZQ_B_DVAB6_0 (GRAMICIDIN D)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	3 / 3	TRP A 410 ALA A 358 VAL A 381	None	0.78A	2izqA-4u7lA: undetectable 2izqB-4u7lA: undetectable	2izqA-4u7lA: 2.88 2izqB-4u7lA: 2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QD4_B_CHDB928_0 (FERROCHELATASE)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	5 / 12	LEU A 371 LEU A 392 MET A 389 VAL A 381 TRP A 410	None	1.24A	2qd4B-4u7lA: undetectable	2qd4B-4u7lA: 23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VCT_A_ASDA1223_1 (GLUTATHIONE S-TRANSFERASE A2)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	4 / 8	ILE A 303 LEU A 274 LEU A 272 PHE A 311	None	0.89A	2vctA-4u7lA: undetectable	2vctA-4u7lA: 20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZBP_A_SAMA300_0 (RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	5 / 12	GLY A 262 LEU A 226 ILE A 186 LEU A 224 LEU A 200	None	0.94A	2zbpA-4u7lA: undetectable	2zbpA-4u7lA: 21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AIA_A_SAMA206_0 (UPF0217 PROTEIN MJ1640)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	4 / 6	LEU A 35 GLY A 16 LEU A 33 SER A 32	None NAG A 501 (-3.8A) None None	0.86A	3aiaA-4u7lA: undetectable	3aiaA-4u7lA: 20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AQI_B_CHDB6_0 (FERROCHELATASE)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	5 / 12	LEU A 371 LEU A 392 MET A 389 ILE A 354 TRP A 410	None	1.30A	3aqiB-4u7lA: undetectable	3aqiB-4u7lA: 23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AQI_B_CHDB6_0 (FERROCHELATASE)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	5 / 12	LEU A 371 LEU A 392 MET A 389 VAL A 381 TRP A 410	None	1.19A	3aqiB-4u7lA: undetectable	3aqiB-4u7lA: 23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IV6_A_SAMA301_1 (PUTATIVE ZN-DEPENDENT ALCOHOL DEHYDROGENASE)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	3 / 3	SER A 32 ASP A 10 ASP A 13	None None NAG A 501 (-3.9A)	0.67A	3iv6A-4u7lA: undetectable	3iv6A-4u7lA: 20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L8L_A_DVAA6_0 (GRAMICIDIN D)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	3 / 3	ALA A 358 VAL A 381 TRP A 410	None	0.77A	3l8lA-4u7lA: undetectable 3l8lB-4u7lA: undetectable	3l8lA-4u7lA: 2.88 3l8lB-4u7lA: 3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MDT_B_VORB506_1 (CHOLESTEROL 24-HYDROXYLASE)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	5 / 11	LEU A 408 ILE A 439 ALA A 429 ALA A 377 ALA A 426	None	1.03A	3mdtB-4u7lA: undetectable	3mdtB-4u7lA: 24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3Z_D_9PLD501_1 (CYTOCHROME P450 2E1)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	4 / 6	LEU A 197 ALA A 167 THR A 190 LEU A 178	None	0.99A	3t3zD-4u7lA: undetectable	3t3zD-4u7lA: 22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TF1_A_ACTA191_0 (METHYL-ACCEPTING CHEMOTAXIS PROTEIN)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	4 / 5	THR A 330 ILE A 331 PHE A 338 LEU A 322	None	1.36A	3tf1A-4u7lA: undetectable	3tf1A-4u7lA: 16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W1W_A_CHDA1502_0 (FERROCHELATASE, MITOCHONDRIAL)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	5 / 12	LEU A 371 LEU A 392 MET A 389 ILE A 354 TRP A 410	None	1.33A	3w1wA-4u7lA: undetectable	3w1wA-4u7lA: 23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W1W_A_CHDA1502_0 (FERROCHELATASE, MITOCHONDRIAL)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	5 / 12	LEU A 371 LEU A 392 MET A 389 VAL A 381 TRP A 410	None	1.21A	3w1wA-4u7lA: undetectable	3w1wA-4u7lA: 23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4F_A_IPHA902_0 (PROTEIN ARGONAUTE-2)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	4 / 7	LEU A 80 PRO A 68 LEU A 101 TYR A 98	None	0.97A	4z4fA-4u7lA: undetectable	4z4fA-4u7lA: 18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDN_G_EVPG2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	4 / 6	GLU A 271 GLY A 340 ASP A 342 GLY A 313	None	0.81A	5cdnA-4u7lA: undetectable 5cdnB-4u7lA: undetectable	5cdnA-4u7lA: 22.00 5cdnB-4u7lA: 17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDN_N_EVPN2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	4 / 6	GLU A 271 GLY A 340 ASP A 342 GLY A 313	None	0.84A	5cdnR-4u7lA: undetectable 5cdnS-4u7lA: undetectable	5cdnR-4u7lA: 22.00 5cdnS-4u7lA: 17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JVZ_B_FLPB601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	5 / 12	LEU A 218 LEU A 202 GLY A 213 ALA A 214 LEU A 210	None	1.14A	5jvzB-4u7lA: undetectable	5jvzB-4u7lA: 22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5T7B_A_IPHA902_0 (PROTEIN ARGONAUTE-2)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	4 / 7	LEU A 80 PRO A 68 LEU A 101 TYR A 98	None	0.99A	5t7bA-4u7lA: undetectable	5t7bA-4u7lA: 18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X23_A_LSNA502_1 (CYTOCHROME P450 2C9)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	5 / 12	VAL A 234 LEU A 242 GLY A 262 LEU A 272 LEU A 250	None	1.06A	5x23A-4u7lA: undetectable	5x23A-4u7lA: 23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XXI_A_LSNA501_1 (CYTOCHROME P450 2C9)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	5 / 12	ALA A 337 VAL A 357 ALA A 385 LEU A 395 LEU A 373	None	0.99A	5xxiA-4u7lA: undetectable	5xxiA-4u7lA: 23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B5V_A_ECLA1001_1 (TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 5)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	4 / 7	PHE A 386 LEU A 371 ILE A 303 ALA A 361	None	0.86A	6b5vA-4u7lA: undetectable 6b5vC-4u7lA: undetectable	6b5vA-4u7lA: 8.77 6b5vC-4u7lA: 8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B5V_C_ECLC1001_1 (TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 5)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	4 / 7	PHE A 386 LEU A 371 ILE A 303 ALA A 361	None	0.87A	6b5vC-4u7lA: undetectable 6b5vD-4u7lA: undetectable	6b5vC-4u7lA: 8.77 6b5vD-4u7lA: 8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B5V_D_ECLD1001_1 (TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 5)	4u7l	LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 (Homo sapiens)	4 / 7	ALA A 361 PHE A 386 LEU A 371 ILE A 303	None	0.86A	6b5vB-4u7lA: undetectable 6b5vD-4u7lA: undetectable	6b5vB-4u7lA: 8.77 6b5vD-4u7lA: 8.77

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1BZF_A_TMQA170_1","DIHYDROFOLATE REDUCTASE","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",5,"LEU A 138;LEU A 155;THR A 190;PHE A 191;LEU A 200","None","1.05A","1bzfA-4u7lA:undetectable","1bzfA-4u7lA:16.49"],["1CMC_B_SAMB105_0","MET REPRESSOR","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",5,"LEU A 224;LEU A 210;ALA A 214;PHE A 191;GLY A 188","None","1.40A","1cmcA-4u7lA:undetectable;1cmcB-4u7lA:undetectable","1cmcA-4u7lA:11.36;1cmcB-4u7lA:11.36"],["1FBM_B_RTLB951_1","PROTEIN (CARTILAGE OLIGOMERIC MATRIX PROTEIN)","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",4,"THR A  30;LEU A  54;VAL A  57;LEU A  80","None","1.03A","1fbmB-4u7lA:undetectable","1fbmB-4u7lA:8.01"],["1HRK_A_CHDA1501_0","FERROCHELATASE","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",5,"LEU A 371;LEU A 392;MET A 389;VAL A 381;TRP A 410","None","1.21A","1hrkA-4u7lA:undetectable","1hrkA-4u7lA:23.94"],["1HRK_B_CHDB2501_0","FERROCHELATASE","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",5,"LEU A 347;LEU A 368;ILE A 327;ARG A 418;VAL A 357","None","1.42A","1hrkB-4u7lA:undetectable","1hrkB-4u7lA:23.94"],["1HRK_B_CHDB2501_0","FERROCHELATASE","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",5,"LEU A 371;LEU A 392;MET A 389;ILE A 354;TRP A 410","None","1.33A","1hrkB-4u7lA:undetectable","1hrkB-4u7lA:23.94"],["1HRK_B_CHDB2501_0","FERROCHELATASE","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",5,"LEU A 371;LEU A 392;MET A 389;VAL A 381;TRP A 410","None","1.16A","1hrkB-4u7lA:undetectable","1hrkB-4u7lA:23.94"],["1MJQ_C_SAMC199_0","METHIONINE REPRESSOR","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",5,"LEU A 224;LEU A 210;ALA A 214;PHE A 191;GLY A 188","None","1.39A","1mjqC-4u7lA:undetectable;1mjqD-4u7lA:undetectable","1mjqC-4u7lA:11.58;1mjqD-4u7lA:11.58"],["1NT6_A_DVAA6_0","GRAMICIDIN C","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",3,"ALA A 358;VAL A 381;TRP A 410","None","0.86A","1nt6A-4u7lA:undetectable","1nt6A-4u7lA:3.12"],["1NT6_B_DVAB6_0","GRAMICIDIN C","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",3,"ALA A 358;VAL A 381;TRP A 410","None","0.86A","1nt6B-4u7lA:undetectable","1nt6B-4u7lA:3.12"],["1TW4_A_CHDA131_0","FATTY ACID-BINDING PROTEIN","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",5,"LEU A 293;ASN A 325;ILE A 303;LEU A 282;PHE A 311","None","1.38A","1tw4A-4u7lA:undetectable","1tw4A-4u7lA:15.76"],["1TW4_A_CHDA131_0","FATTY ACID-BINDING PROTEIN","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",5,"LEU A 341;ASN A 325;ILE A 303;LEU A 282;THR A 330","None","1.24A","1tw4A-4u7lA:undetectable","1tw4A-4u7lA:15.76"],["1TW4_B_CHDB1131_0","FATTY ACID-BINDING PROTEIN","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",5,"LEU A 344;ASN A 325;ILE A 303;THR A 330;PHE A 338","None","1.47A","1tw4B-4u7lA:undetectable","1tw4B-4u7lA:15.76"],["1U18_B_HSMB402_1","NITROPHORIN 1","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",4,"GLU A  49;THR A  30;LEU A  54;LEU A  26","None","1.14A","1u18B-4u7lA:undetectable","1u18B-4u7lA:16.99"],["1XDK_B_9CRB600_1","RETINOIC ACID RECEPTOR, BETA","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",5,"ALA A 142;LEU A 128;ILE A 125;LEU A  95;LEU A 130","None","1.21A","1xdkB-4u7lA:undetectable","1xdkB-4u7lA:22.46"],["2HDN_B_TACB1888_1","ELONGATION FACTOR EF-TU;ELONGATION FACTOR EF-TU;ELONGATION FACTOR EF-TU","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",4,"THR A 348;SER A 299;ASP A 323;SER A 275","None","1.07A","2hdnA-4u7lA:undetectable;2hdnB-4u7lA:undetectable;2hdnD-4u7lA:undetectable","2hdnA-4u7lA:6.58;2hdnB-4u7lA:20.17;2hdnD-4u7lA:20.17"],["2HDN_D_TACD2888_1","ELONGATION FACTOR EF-TU;ELONGATION FACTOR EF-TU;ELONGATION FACTOR EF-TU","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",4,"SER A 275;THR A 348;SER A 299;ASP A 323","None","1.13A","2hdnB-4u7lA:undetectable;2hdnC-4u7lA:undetectable;2hdnD-4u7lA:undetectable","2hdnB-4u7lA:20.17;2hdnC-4u7lA:6.58;2hdnD-4u7lA:20.17"],["2HRC_B_CHDB1605_0","FERROCHELATASE","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",5,"LEU A 371;LEU A 392;MET A 389;VAL A 381;TRP A 410","None","1.15A","2hrcB-4u7lA:undetectable","2hrcB-4u7lA:23.94"],["2IZQ_B_DVAB6_0","GRAMICIDIN D","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",3,"TRP A 410;ALA A 358;VAL A 381","None","0.78A","2izqA-4u7lA:undetectable;2izqB-4u7lA:undetectable","2izqA-4u7lA:2.88;2izqB-4u7lA:2.88"],["2QD4_B_CHDB928_0","FERROCHELATASE","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",5,"LEU A 371;LEU A 392;MET A 389;VAL A 381;TRP A 410","None","1.24A","2qd4B-4u7lA:undetectable","2qd4B-4u7lA:23.84"],["2VCT_A_ASDA1223_1","GLUTATHIONE S-TRANSFERASE A2","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",4,"ILE A 303;LEU A 274;LEU A 272;PHE A 311","None","0.89A","2vctA-4u7lA:undetectable","2vctA-4u7lA:20.09"],["2ZBP_A_SAMA300_0","RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",5,"GLY A 262;LEU A 226;ILE A 186;LEU A 224;LEU A 200","None","0.94A","2zbpA-4u7lA:undetectable","2zbpA-4u7lA:21.04"],["3AIA_A_SAMA206_0","UPF0217 PROTEIN MJ1640","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",4,"LEU A  35;GLY A  16;LEU A  33;SER A  32","None;NAG A 501 (-3.8A);None;None","0.86A","3aiaA-4u7lA:undetectable","3aiaA-4u7lA:20.09"],["3AQI_B_CHDB6_0","FERROCHELATASE","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",5,"LEU A 371;LEU A 392;MET A 389;ILE A 354;TRP A 410","None","1.30A","3aqiB-4u7lA:undetectable","3aqiB-4u7lA:23.94"],["3AQI_B_CHDB6_0","FERROCHELATASE","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",5,"LEU A 371;LEU A 392;MET A 389;VAL A 381;TRP A 410","None","1.19A","3aqiB-4u7lA:undetectable","3aqiB-4u7lA:23.94"],["3IV6_A_SAMA301_1","PUTATIVE ZN-DEPENDENT ALCOHOL DEHYDROGENASE","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",3,"SER A  32;ASP A  10;ASP A  13","None;None;NAG A 501 (-3.9A)","0.67A","3iv6A-4u7lA:undetectable","3iv6A-4u7lA:20.66"],["3L8L_A_DVAA6_0","GRAMICIDIN D","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",3,"ALA A 358;VAL A 381;TRP A 410","None","0.77A","3l8lA-4u7lA:undetectable;3l8lB-4u7lA:undetectable","3l8lA-4u7lA:2.88;3l8lB-4u7lA:3.12"],["3MDT_B_VORB506_1","CHOLESTEROL 24-HYDROXYLASE","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",5,"LEU A 408;ILE A 439;ALA A 429;ALA A 377;ALA A 426","None","1.03A","3mdtB-4u7lA:undetectable","3mdtB-4u7lA:24.17"],["3T3Z_D_9PLD501_1","CYTOCHROME P450 2E1","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",4,"LEU A 197;ALA A 167;THR A 190;LEU A 178","None","0.99A","3t3zD-4u7lA:undetectable","3t3zD-4u7lA:22.35"],["3TF1_A_ACTA191_0","METHYL-ACCEPTING CHEMOTAXIS PROTEIN","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",4,"THR A 330;ILE A 331;PHE A 338;LEU A 322","None","1.36A","3tf1A-4u7lA:undetectable","3tf1A-4u7lA:16.59"],["3W1W_A_CHDA1502_0","FERROCHELATASE, MITOCHONDRIAL","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",5,"LEU A 371;LEU A 392;MET A 389;ILE A 354;TRP A 410","None","1.33A","3w1wA-4u7lA:undetectable","3w1wA-4u7lA:23.17"],["3W1W_A_CHDA1502_0","FERROCHELATASE, MITOCHONDRIAL","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",5,"LEU A 371;LEU A 392;MET A 389;VAL A 381;TRP A 410","None","1.21A","3w1wA-4u7lA:undetectable","3w1wA-4u7lA:23.17"],["4Z4F_A_IPHA902_0","PROTEIN ARGONAUTE-2","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",4,"LEU A  80;PRO A  68;LEU A 101;TYR A  98","None","0.97A","4z4fA-4u7lA:undetectable","4z4fA-4u7lA:18.49"],["5CDN_G_EVPG2101_1","DNA GYRASE SUBUNIT A;DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",4,"GLU A 271;GLY A 340;ASP A 342;GLY A 313","None","0.81A","5cdnA-4u7lA:undetectable;5cdnB-4u7lA:undetectable","5cdnA-4u7lA:22.00;5cdnB-4u7lA:17.17"],["5CDN_N_EVPN2101_1","DNA GYRASE SUBUNIT A;DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",4,"GLU A 271;GLY A 340;ASP A 342;GLY A 313","None","0.84A","5cdnR-4u7lA:undetectable;5cdnS-4u7lA:undetectable","5cdnR-4u7lA:22.00;5cdnS-4u7lA:17.17"],["5JVZ_B_FLPB601_1","PROSTAGLANDIN G\/H SYNTHASE 2","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",5,"LEU A 218;LEU A 202;GLY A 213;ALA A 214;LEU A 210","None","1.14A","5jvzB-4u7lA:undetectable","5jvzB-4u7lA:22.73"],["5T7B_A_IPHA902_0","PROTEIN ARGONAUTE-2","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",4,"LEU A  80;PRO A  68;LEU A 101;TYR A  98","None","0.99A","5t7bA-4u7lA:undetectable","5t7bA-4u7lA:18.56"],["5X23_A_LSNA502_1","CYTOCHROME P450 2C9","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",5,"VAL A 234;LEU A 242;GLY A 262;LEU A 272;LEU A 250","None","1.06A","5x23A-4u7lA:undetectable","5x23A-4u7lA:23.43"],["5XXI_A_LSNA501_1","CYTOCHROME P450 2C9","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",5,"ALA A 337;VAL A 357;ALA A 385;LEU A 395;LEU A 373","None","0.99A","5xxiA-4u7lA:undetectable","5xxiA-4u7lA:23.66"],["6B5V_A_ECLA1001_1","TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 5;TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 5","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",4,"PHE A 386;LEU A 371;ILE A 303;ALA A 361","None","0.86A","6b5vA-4u7lA:undetectable;6b5vC-4u7lA:undetectable","6b5vA-4u7lA:8.77;6b5vC-4u7lA:8.77"],["6B5V_C_ECLC1001_1","TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 5;TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 5","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",4,"PHE A 386;LEU A 371;ILE A 303;ALA A 361","None","0.87A","6b5vC-4u7lA:undetectable;6b5vD-4u7lA:undetectable","6b5vC-4u7lA:8.77;6b5vD-4u7lA:8.77"],["6B5V_D_ECLD1001_1","TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 5;TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 5","4u7l","LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1","Homo sapiens",4,"ALA A 361;PHE A 386;LEU A 371;ILE A 303","None","0.86A","6b5vB-4u7lA:undetectable;6b5vD-4u7lA:undetectable","6b5vB-4u7lA:8.77;6b5vD-4u7lA:8.77"]]