SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u7m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4u7m LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A 521
HIS A 582
SER A 524
LYS A 494
 None
 1.16A 1eqbA-4u7mA:
undetectable
1eqbB-4u7mA:
undetectable		 1eqbA-4u7mA:
21.31
1eqbB-4u7mA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4u7m LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A 521
HIS A 582
SER A 524
LYS A 494
 None
 1.16A 1eqbA-4u7mA:
undetectable
1eqbB-4u7mA:
undetectable		 1eqbA-4u7mA:
21.31
1eqbB-4u7mA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4u7m LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A 521
HIS A 582
SER A 524
LYS A 494
 None
 1.16A 1eqbC-4u7mA:
undetectable
1eqbD-4u7mA:
undetectable		 1eqbC-4u7mA:
21.31
1eqbD-4u7mA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4u7m LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A 521
HIS A 582
SER A 524
LYS A 494
 None
 1.16A 1eqbC-4u7mA:
undetectable
1eqbD-4u7mA:
undetectable		 1eqbC-4u7mA:
21.31
1eqbD-4u7mA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4u7m LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A 521
HIS A 582
SER A 524
LYS A 494
 None
 1.25A 2vmyA-4u7mA:
undetectable
2vmyB-4u7mA:
undetectable		 2vmyA-4u7mA:
22.01
2vmyB-4u7mA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 4u7m LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1
(Homo
sapiens) 		4 / 8 ASN A 676
GLN A 675
GLY A 679
SER A 680
 None
 0.84A 4f93B-4u7mA:
undetectable		 4f93B-4u7mA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 4u7m LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1
(Homo
sapiens) 		4 / 8 ARG A 647
VAL A 662
ASP A 665
ASP A 666
 None
 1.02A 4xqgA-4u7mA:
undetectable		 4xqgA-4u7mA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 4u7m LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1
(Homo
sapiens) 		4 / 8 ARG A 647
VAL A 662
ASP A 665
ASP A 666
 None
 1.01A 4xqgB-4u7mA:
undetectable		 4xqgB-4u7mA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4u7m LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1
(Homo
sapiens) 		4 / 8 ALA A 519
SER A 517
HIS A 547
HIS A 549
 None
 1.07A 5km8A-4u7mA:
undetectable
5km8B-4u7mA:
undetectable		 5km8A-4u7mA:
18.46
5km8B-4u7mA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 4u7m LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1
(Homo
sapiens) 		5 / 12 ALA A 685
LEU A 687
THR A 614
ALA A 616
ILE A 659
 None
 1.16A 5xiwD-4u7mA:
undetectable		 5xiwD-4u7mA:
14.24