SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u7t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 GLY A 646
SER A 638
ALA A 662
GLY A 673
ILE A 670
 None
 1.02A 1gtnL-4u7tA:
undetectable
1gtnV-4u7tA:
undetectable		 1gtnL-4u7tA:
9.89
1gtnV-4u7tA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 SER A 638
TYR A 660
PHE A 794
VAL A 895
PHE A 870
 None
 1.46A 1q23D-4u7tA:
undetectable
1q23E-4u7tA:
undetectable		 1q23D-4u7tA:
17.52
1q23E-4u7tA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 10 SER A 638
TYR A 660
PHE A 794
VAL A 895
PHE A 870
 None
 1.49A 1q23E-4u7tA:
undetectable		 1q23E-4u7tA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 11 SER A 638
TYR A 660
PHE A 794
VAL A 895
PHE A 870
 None
 1.43A 1q23G-4u7tA:
undetectable		 1q23G-4u7tA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 10 SER A 638
TYR A 660
PHE A 794
VAL A 895
PHE A 870
 None
 1.45A 1q23K-4u7tA:
undetectable		 1q23K-4u7tA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		6 / 12 GLY A 673
HIS A 677
ILE A 670
GLY A 646
SER A 638
ALA A 662
 None
 1.37A 1utdL-4u7tA:
undetectable
1utdM-4u7tA:
undetectable		 1utdL-4u7tA:
9.89
1utdM-4u7tA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 GLY A 673
ILE A 670
GLY A 646
SER A 638
ALA A 662
 None
 0.98A 1utdO-4u7tA:
undetectable
1utdP-4u7tA:
undetectable		 1utdO-4u7tA:
9.89
1utdP-4u7tA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 11 GLY A 673
ILE A 670
GLY A 646
SER A 638
ALA A 662
 None
 0.93A 1utdP-4u7tA:
undetectable
1utdQ-4u7tA:
undetectable		 1utdP-4u7tA:
9.89
1utdQ-4u7tA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		6 / 12 PHE A 640
GLY A 642
GLY A 646
ASP A 686
PRO A 709
LEU A 730
 SAH  A1004 (-4.6A)
SAH  A1004 (-3.3A)
None
SAH  A1004 (-3.0A)
SAH  A1004 ( 3.9A)
SAH  A1004 ( 4.9A)
 1.18A 2hmyB-4u7tA:
19.6		 2hmyB-4u7tA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		4 / 6 LEU A 639
PHE A 701
ILE A 695
VAL A 690
 None
 1.02A 2j5mA-4u7tA:
undetectable		 2j5mA-4u7tA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		4 / 7 ALA A 644
TYR A 660
TYR A 874
HIS A 677
 None
 1.45A 2pncA-4u7tA:
undetectable		 2pncA-4u7tA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 GLY A 642
ASP A 686
VAL A 687
ARG A 688
GLY A 707
 SAH  A1004 (-3.3A)
SAH  A1004 (-3.0A)
SAH  A1004 (-3.7A)
SAH  A1004 (-4.4A)
None
 0.68A 2qe6A-4u7tA:
5.5		 2qe6A-4u7tA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 GLY A 642
ASP A 686
VAL A 687
ARG A 688
GLY A 707
 SAH  A1004 (-3.3A)
SAH  A1004 (-3.0A)
SAH  A1004 (-3.7A)
SAH  A1004 (-4.4A)
None
 0.69A 2qe6B-4u7tA:
5.5		 2qe6B-4u7tA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 PRO A 709
PHE A 640
GLY A 642
THR A 645
GLU A 664
 SAH  A1004 ( 3.9A)
SAH  A1004 (-4.6A)
SAH  A1004 (-3.3A)
SAH  A1004 (-3.3A)
SAH  A1004 (-3.0A)
 0.73A 2zifA-4u7tA:
undetectable		 2zifA-4u7tA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 GLY A 728
ASP A 768
ILE A 769
LEU A 713
ARG A 720
 None
 1.30A 3iv6B-4u7tA:
7.1		 3iv6B-4u7tA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 11 LEU A 723
GLY A 726
LEU A 713
ASN A 757
LEU A 730
 None
None
None
None
SAH  A1004 ( 4.9A)
 1.35A 3ndvA-4u7tA:
undetectable
3ndvB-4u7tA:
undetectable		 3ndvA-4u7tA:
22.93
3ndvB-4u7tA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 11 GLY A 726
LEU A 713
ASN A 757
LEU A 730
LEU A 723
 None
None
None
SAH  A1004 ( 4.9A)
None
 1.34A 3ndvC-4u7tA:
undetectable
3ndvD-4u7tA:
undetectable		 3ndvC-4u7tA:
22.93
3ndvD-4u7tA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 11 GLY A 642
ASP A 686
VAL A 687
PRO A 709
LEU A 730
 SAH  A1004 (-3.3A)
SAH  A1004 (-3.0A)
SAH  A1004 (-3.7A)
SAH  A1004 ( 3.9A)
SAH  A1004 ( 4.9A)
 0.91A 3v8vB-4u7tA:
7.4		 3v8vB-4u7tA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		4 / 6 CYH A 554
ASN A 551
CYH A 549
GLY A 550
 ZN  A1003 (-2.2A)
None
ZN  A1003 (-2.5A)
None
 1.38A 3w9tE-4u7tA:
undetectable		 3w9tE-4u7tA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		4 / 7 GLY A 543
GLY A 542
TYR A 536
GLU A 561
 ZN  A1002 ( 4.6A)
None
None
None
 1.05A 4fgkB-4u7tA:
3.6		 4fgkB-4u7tA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		4 / 8 HIS A 677
ARG A 676
ASP A 652
LEU A 648
 None
 0.88A 4k0bA-4u7tA:
undetectable		 4k0bA-4u7tA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		4 / 8 HIS A 677
ARG A 676
ASP A 652
LEU A 648
 None
 0.92A 4l7iA-4u7tA:
undetectable		 4l7iA-4u7tA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		3 / 3 HIS A 506
TRP A 601
SER A 496
 None
 1.15A 4lrhD-4u7tA:
undetectable		 4lrhD-4u7tA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		3 / 3 TYR A 526
GLY A 800
PRO A 799
 None
 0.73A 4qwpA-4u7tA:
undetectable		 4qwpA-4u7tA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 11 PHE A 521
PHE A 608
GLY A 511
GLY A 512
ILE A 493
 None
 1.22A 4zvmA-4u7tA:
3.6
4zvmB-4u7tA:
3.8		 4zvmA-4u7tA:
18.87
4zvmB-4u7tA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		3 / 3 VAL A 872
THR A 862
ARG A 866
 None
 0.70A 5b2sB-4u7tA:
undetectable		 5b2sB-4u7tA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		3 / 3 VAL A 872
THR A 862
ARG A 866
 None
 0.72A 5b2tB-4u7tA:
undetectable		 5b2tB-4u7tA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		6 / 12 ASP A 686
PRO A 709
PHE A 640
GLY A 642
THR A 645
GLU A 664
 SAH  A1004 (-3.0A)
SAH  A1004 ( 3.9A)
SAH  A1004 (-4.6A)
SAH  A1004 (-3.3A)
SAH  A1004 (-3.3A)
SAH  A1004 (-3.0A)
 0.60A 5hfjA-4u7tA:
undetectable		 5hfjA-4u7tA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 ASP A 686
PRO A 709
PHE A 640
GLY A 642
THR A 645
 SAH  A1004 (-3.0A)
SAH  A1004 ( 3.9A)
SAH  A1004 (-4.6A)
SAH  A1004 (-3.3A)
SAH  A1004 (-3.3A)
 0.48A 5hfjC-4u7tA:
2.1		 5hfjC-4u7tA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		6 / 12 ASP A 686
PRO A 709
PHE A 640
GLY A 642
THR A 645
GLU A 664
 SAH  A1004 (-3.0A)
SAH  A1004 ( 3.9A)
SAH  A1004 (-4.6A)
SAH  A1004 (-3.3A)
SAH  A1004 (-3.3A)
SAH  A1004 (-3.0A)
 0.65A 5hfjD-4u7tA:
undetectable		 5hfjD-4u7tA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 ASP A 686
PHE A 640
GLY A 642
THR A 645
GLU A 664
 SAH  A1004 (-3.0A)
SAH  A1004 (-4.6A)
SAH  A1004 (-3.3A)
SAH  A1004 (-3.3A)
SAH  A1004 (-3.0A)
 0.71A 5hfjE-4u7tA:
undetectable		 5hfjE-4u7tA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 ASP A 686
PRO A 709
PHE A 640
GLY A 642
GLU A 664
 SAH  A1004 (-3.0A)
SAH  A1004 ( 3.9A)
SAH  A1004 (-4.6A)
SAH  A1004 (-3.3A)
SAH  A1004 (-3.0A)
 0.47A 5hfjF-4u7tA:
2.2		 5hfjF-4u7tA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 ASP A 686
PRO A 709
PHE A 640
GLY A 642
THR A 645
 SAH  A1004 (-3.0A)
SAH  A1004 ( 3.9A)
SAH  A1004 (-4.6A)
SAH  A1004 (-3.3A)
SAH  A1004 (-3.3A)
 0.54A 5hfjH-4u7tA:
2.1		 5hfjH-4u7tA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		6 / 11 PHE A 640
GLY A 642
GLU A 664
ASP A 686
VAL A 687
PRO A 709
 SAH  A1004 (-4.6A)
SAH  A1004 (-3.3A)
SAH  A1004 (-3.0A)
SAH  A1004 (-3.0A)
SAH  A1004 (-3.7A)
SAH  A1004 ( 3.9A)
 0.66A 5hjiA-4u7tA:
2.2		 5hjiA-4u7tA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 VAL A 687
LEU A 738
PHE A 755
LEU A 773
ARG A 729
 SAH  A1004 (-3.7A)
None
None
None
None
 1.34A 5hnxB-4u7tA:
undetectable		 5hnxB-4u7tA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		4 / 5 CYH A 497
ILE A 495
CYH A 494
HIS A 506
 ZN  A1001 (-2.2A)
None
ZN  A1001 (-2.1A)
None
 1.43A 5hrqC-4u7tA:
undetectable
5hrqD-4u7tA:
undetectable
5hrqL-4u7tA:
undetectable		 5hrqC-4u7tA:
3.60
5hrqD-4u7tA:
7.67
5hrqL-4u7tA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 ASP A 686
ARG A 688
PRO A 709
LEU A 730
PHE A 640
 SAH  A1004 (-3.0A)
SAH  A1004 (-4.4A)
SAH  A1004 ( 3.9A)
SAH  A1004 ( 4.9A)
SAH  A1004 (-4.6A)
 0.81A 5k7uA-4u7tA:
undetectable		 5k7uA-4u7tA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		3 / 3 ARG A 488
PHE A 475
LEU A 500
 None
 0.84A 5x1bC-4u7tA:
undetectable		 5x1bC-4u7tA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		4 / 5 ARG A 488
LEU A 479
PHE A 475
LEU A 500
 None
 1.14A 5x1fC-4u7tA:
undetectable
5x1fJ-4u7tA:
undetectable		 5x1fC-4u7tA:
19.46
5x1fJ-4u7tA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		4 / 5 ARG A 488
LEU A 479
PHE A 475
LEU A 500
 None
 1.12A 5xdxC-4u7tA:
undetectable
5xdxJ-4u7tA:
undetectable		 5xdxC-4u7tA:
19.46
5xdxJ-4u7tA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		4 / 5 ARG A 488
LEU A 479
PHE A 475
LEU A 500
 None
 1.17A 5xdxP-4u7tA:
undetectable
5xdxW-4u7tA:
undetectable		 5xdxP-4u7tA:
19.46
5xdxW-4u7tA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		4 / 5 TRP A 860
LEU A 859
VAL A 850
LEU A 819
 None
 1.02A 5xooB-4u7tA:
undetectable		 5xooB-4u7tA:
10.09