SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u83'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 4u83 ACYL-COA
DEHYDROGENASE
(Brucella
abortus) 		5 / 9 ALA A  68
GLU A 305
VAL A 297
GLY A 239
GLY A 243
 None
 1.26A 1bcuH-4u83A:
undetectable		 1bcuH-4u83A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4u83 ACYL-COA
DEHYDROGENASE
(Brucella
abortus) 		4 / 7 PHE A  35
GLY A  44
ILE A  84
VAL A  85
 None
 0.82A 1p2yA-4u83A:
undetectable		 1p2yA-4u83A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4u83 ACYL-COA
DEHYDROGENASE
(Brucella
abortus) 		4 / 5 LEU A  71
ALA A  70
LEU A  62
MET A  94
 None
None
EDO  A 401 ( 4.9A)
None
 1.24A 2oaxA-4u83A:
undetectable		 2oaxA-4u83A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 4u83 ACYL-COA
DEHYDROGENASE
(Brucella
abortus) 		4 / 4 ALA A 258
TYR A 345
ALA A 332
TYR A 262
 None
 1.31A 2wlkA-4u83A:
2.9
2wlkB-4u83A:
2.7		 2wlkA-4u83A:
21.94
2wlkB-4u83A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4u83 ACYL-COA
DEHYDROGENASE
(Brucella
abortus) 		6 / 12 TYR A 360
GLY A  79
ILE A 350
ILE A  84
SER A 205
ALA A  80
 None
 1.48A 4qtuD-4u83A:
undetectable		 4qtuD-4u83A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 4u83 ACYL-COA
DEHYDROGENASE
(Brucella
abortus) 		5 / 12 SER A 157
GLY A 161
ALA A 113
MET A 112
GLY A 115
 None
 1.17A 4r29A-4u83A:
2.9		 4r29A-4u83A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 4u83 ACYL-COA
DEHYDROGENASE
(Brucella
abortus) 		5 / 12 SER A 157
GLY A 161
ALA A 113
MET A 112
GLY A 115
 None
 1.12A 4r29C-4u83A:
4.1		 4r29C-4u83A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 4u83 ACYL-COA
DEHYDROGENASE
(Brucella
abortus) 		5 / 12 TYR A 360
ILE A 165
GLU A 125
ALA A 181
ALA A 233
 None
 1.16A 5n5dB-4u83A:
undetectable		 5n5dB-4u83A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 4u83 ACYL-COA
DEHYDROGENASE
(Brucella
abortus) 		4 / 8 GLY A 100
ARG A 107
TRP A  57
ASP A 103
 None
 0.97A 5vlmA-4u83A:
2.2		 5vlmA-4u83A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 4u83 ACYL-COA
DEHYDROGENASE
(Brucella
abortus) 		4 / 8 GLY A 100
ARG A 107
TRP A  57
ASP A 103
 None
 0.82A 5vlmB-4u83A:
undetectable		 5vlmB-4u83A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 4u83 ACYL-COA
DEHYDROGENASE
(Brucella
abortus) 		5 / 12 ALA A 248
GLY A 250
GLU A  73
LEU A  71
ASP A  78
 None
 1.39A 5vlmF-4u83A:
undetectable		 5vlmF-4u83A:
20.26