SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u89'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 4u89 PHOSPHOPANTETHEINYL
TRANSFERASE PPTT
(Mycobacterium
tuberculosis) 		5 / 9 ILE A  73
VAL A 102
GLY A  89
ALA A  59
LEU A  63
 None
 1.02A 1e7bA-4u89A:
undetectable		 1e7bA-4u89A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 4u89 PHOSPHOPANTETHEINYL
TRANSFERASE PPTT
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 210
LEU A 227
ILE A 178
PRO A  12
VAL A  15
 None
 1.44A 1hrkB-4u89A:
undetectable		 1hrkB-4u89A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 4u89 PHOSPHOPANTETHEINYL
TRANSFERASE PPTT
(Mycobacterium
tuberculosis) 		5 / 10 VAL A  10
VAL A   7
VAL A 111
ILE A 225
VAL A 226
 None
 1.17A 2qboA-4u89A:
undetectable		 2qboA-4u89A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 4u89 PHOSPHOPANTETHEINYL
TRANSFERASE PPTT
(Mycobacterium
tuberculosis) 		3 / 3 LEU A  11
PRO A  12
LEU A  19
 None
 0.49A 2qd5B-4u89A:
undetectable		 2qd5B-4u89A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4u89 PHOSPHOPANTETHEINYL
TRANSFERASE PPTT
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  19
VAL A   7
ALA A 107
SER A  90
GLY A 112
 None
 1.15A 2vmyB-4u89A:
undetectable		 2vmyB-4u89A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4u89 PHOSPHOPANTETHEINYL
TRANSFERASE PPTT
(Mycobacterium
tuberculosis) 		6 / 12 LEU A  19
LEU A  11
VAL A   7
ALA A 107
SER A  90
GLY A 112
 None
 1.47A 2vmyA-4u89A:
undetectable		 2vmyA-4u89A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4u89 PHOSPHOPANTETHEINYL
TRANSFERASE PPTT
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 210
LEU A 227
ILE A 178
PRO A  12
VAL A  15
 None
 1.42A 3w1wB-4u89A:
undetectable		 3w1wB-4u89A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 4u89 PHOSPHOPANTETHEINYL
TRANSFERASE PPTT
(Mycobacterium
tuberculosis) 		5 / 7 LYS A 156
LEU A 152
THR A 159
ALA A 155
THR A 223
 None
None
COA  A 301 ( 4.5A)
None
None
 1.46A 4ik7A-4u89A:
undetectable		 4ik7A-4u89A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 4u89 PHOSPHOPANTETHEINYL
TRANSFERASE PPTT
(Mycobacterium
tuberculosis) 		3 / 3 LYS A 156
LEU A 152
ALA A 155
 None
 0.57A 4ikiA-4u89A:
undetectable		 4ikiA-4u89A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4u89 PHOSPHOPANTETHEINYL
TRANSFERASE PPTT
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 210
THR A 167
LEU A 166
LEU A 207
 None
 0.72A 4z90F-4u89A:
undetectable
4z90G-4u89A:
undetectable
4z90H-4u89A:
undetectable
4z90I-4u89A:
undetectable
4z90J-4u89A:
undetectable		 4z90F-4u89A:
21.93
4z90G-4u89A:
21.93
4z90H-4u89A:
21.93
4z90I-4u89A:
21.93
4z90J-4u89A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4u89 PHOSPHOPANTETHEINYL
TRANSFERASE PPTT
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 153
SER A 130
LEU A 126
LEU A 121
 None
 1.34A 5dzke-4u89A:
undetectable
5dzks-4u89A:
undetectable		 5dzke-4u89A:
22.14
5dzks-4u89A:
1.42