SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u8d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4u8d SORCIN
(Homo
sapiens) 		4 / 4 ARG A  76
GLN A  55
PHE A  70
LEU A  77
 None
 1.28A 3abkC-4u8dA:
undetectable		 3abkC-4u8dA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4u8d SORCIN
(Homo
sapiens) 		4 / 5 ARG A  76
GLN A  55
PHE A  70
LEU A  77
 None
 1.35A 3ablC-4u8dA:
undetectable
3ablJ-4u8dA:
undetectable		 3ablC-4u8dA:
21.98
3ablJ-4u8dA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 4u8d SORCIN
(Homo
sapiens) 		5 / 12 LEU A  58
GLY A  62
LEU A  35
ILE A 160
PHE A 156
 None
 1.24A 4p6xA-4u8dA:
undetectable		 4p6xA-4u8dA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 4u8d SORCIN
(Homo
sapiens) 		5 / 12 LEU A  58
GLY A  62
LEU A  35
ILE A 160
PHE A 156
 None
 1.29A 4p6xE-4u8dA:
undetectable		 4p6xE-4u8dA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 4u8d SORCIN
(Homo
sapiens) 		5 / 12 LEU A  58
GLY A  62
LEU A  35
ILE A 160
PHE A 156
 None
 1.27A 4p6xI-4u8dA:
undetectable		 4p6xI-4u8dA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4u8d SORCIN
(Homo
sapiens) 		5 / 11 LEU A  54
ASP A  83
ALA A  51
ASP A  46
ASP A  85
 None
MG  A 201 (-3.2A)
None
None
MG  A 201 (-2.8A)
 1.34A 4uuuA-4u8dA:
undetectable
4uuuB-4u8dA:
undetectable		 4uuuA-4u8dA:
20.49
4uuuB-4u8dA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 4u8d SORCIN
(Homo
sapiens) 		4 / 7 TYR A 159
PHE A  70
ALA A  64
ILE A 110
 None
 1.01A 4uymA-4u8dA:
1.1		 4uymA-4u8dA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 4u8d SORCIN
(Homo
sapiens) 		4 / 7 TYR A 159
PHE A  70
ALA A  64
ILE A 110
 None
 1.01A 4uymB-4u8dA:
undetectable		 4uymB-4u8dA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4u8d SORCIN
(Homo
sapiens) 		4 / 6 CYH A 162
LEU A 166
HIS A 108
LEU A 129
 None
 1.15A 5hpuC-4u8dA:
undetectable
5hpuD-4u8dA:
undetectable		 5hpuC-4u8dA:
9.15
5hpuD-4u8dA:
12.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MRA_B_DM2B204_1
(SORCIN)		 4u8d SORCIN
(Homo
sapiens) 		4 / 6 THR A 170
ARG A 174
ASP A 177
GLY A 182
 None
 0.58A 5mraA-4u8dA:
23.2
5mraB-4u8dA:
22.3		 5mraA-4u8dA:
84.34
5mraB-4u8dA:
84.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4u8d SORCIN
(Homo
sapiens) 		4 / 6 ARG A  76
GLN A  55
PHE A  70
LEU A  77
 None
 1.33A 6nmpC-4u8dA:
undetectable
6nmpJ-4u8dA:
undetectable		 6nmpC-4u8dA:
21.98
6nmpJ-4u8dA:
15.24