SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u8g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 4u8g PUTATIVE
UNCHARACTERIZED
PROTEIN GBS1891
(Streptococcus
agalactiae) 		5 / 9 ASP A  71
GLY A  21
ILE A  19
VAL A  82
ILE A  78
 None
 0.95A 1hpvB-4u8gA:
undetectable		 1hpvB-4u8gA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 4u8g PUTATIVE
UNCHARACTERIZED
PROTEIN GBS1891
(Streptococcus
agalactiae) 		5 / 9 ASP A  45
GLY A  21
GLY A 100
ILE A 101
ILE A  46
 None
 1.09A 1hxwA-4u8gA:
undetectable		 1hxwA-4u8gA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 4u8g PUTATIVE
UNCHARACTERIZED
PROTEIN GBS1891
(Streptococcus
agalactiae) 		5 / 9 ASP A  71
GLY A  21
ILE A  19
VAL A  82
ILE A  78
 None
 0.88A 1hxwA-4u8gA:
undetectable		 1hxwA-4u8gA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 4u8g PUTATIVE
UNCHARACTERIZED
PROTEIN GBS1891
(Streptococcus
agalactiae) 		4 / 8 ILE A 250
LEU A 242
LYS A 171
GLY A 192
 None
 0.80A 1os6A-4u8gA:
undetectable		 1os6A-4u8gA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 4u8g PUTATIVE
UNCHARACTERIZED
PROTEIN GBS1891
(Streptococcus
agalactiae) 		5 / 10 ASP A  71
ILE A  78
GLY A  21
PRO A 126
ALA A 125
 None
 1.05A 1sh9B-4u8gA:
undetectable		 1sh9B-4u8gA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 4u8g PUTATIVE
UNCHARACTERIZED
PROTEIN GBS1891
(Streptococcus
agalactiae) 		5 / 11 ASP A  71
GLY A  21
ILE A  19
VAL A  82
ILE A  78
 None
 1.01A 3ekxB-4u8gA:
undetectable		 3ekxB-4u8gA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 4u8g PUTATIVE
UNCHARACTERIZED
PROTEIN GBS1891
(Streptococcus
agalactiae) 		3 / 3 LYS A 140
ILE A  19
PHE A  43
 None
 0.93A 3j7zS-4u8gA:
undetectable
3j7za-4u8gA:
undetectable		 3j7zS-4u8gA:
15.77
3j7za-4u8gA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 4u8g PUTATIVE
UNCHARACTERIZED
PROTEIN GBS1891
(Streptococcus
agalactiae) 		5 / 12 PHE A  34
ILE A 148
ILE A 177
ALA A 178
GLY A 143
 None
 0.92A 3nxuA-4u8gA:
undetectable		 3nxuA-4u8gA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 4u8g PUTATIVE
UNCHARACTERIZED
PROTEIN GBS1891
(Streptococcus
agalactiae) 		4 / 8 ILE A 250
LEU A 242
LYS A 171
GLY A 192
 None
 0.89A 3selX-4u8gA:
undetectable		 3selX-4u8gA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 4u8g PUTATIVE
UNCHARACTERIZED
PROTEIN GBS1891
(Streptococcus
agalactiae) 		4 / 6 ILE A 250
LEU A 242
LYS A 171
GLY A 192
 None
 0.77A 3sj1X-4u8gA:
undetectable		 3sj1X-4u8gA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 4u8g PUTATIVE
UNCHARACTERIZED
PROTEIN GBS1891
(Streptococcus
agalactiae) 		5 / 10 ASP A  71
GLY A  21
ILE A  19
VAL A  82
ILE A  78
 None
 1.02A 4dqcA-4u8gA:
undetectable		 4dqcA-4u8gA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 4u8g PUTATIVE
UNCHARACTERIZED
PROTEIN GBS1891
(Streptococcus
agalactiae) 		5 / 10 GLY A  21
ALA A  22
ILE A  19
ILE A 146
ILE A 148
 None
 1.09A 4dt8B-4u8gA:
undetectable		 4dt8B-4u8gA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 4u8g PUTATIVE
UNCHARACTERIZED
PROTEIN GBS1891
(Streptococcus
agalactiae) 		4 / 7 ILE A 250
LEU A 242
LYS A 171
GLY A 192
 None
 0.81A 4hbfA-4u8gA:
undetectable		 4hbfA-4u8gA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 4u8g PUTATIVE
UNCHARACTERIZED
PROTEIN GBS1891
(Streptococcus
agalactiae) 		4 / 7 ILE A 250
LEU A 242
LYS A 171
GLY A 192
 None
 0.79A 4hc3A-4u8gA:
undetectable		 4hc3A-4u8gA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 4u8g PUTATIVE
UNCHARACTERIZED
PROTEIN GBS1891
(Streptococcus
agalactiae) 		4 / 4 PHE A  43
ASP A  45
GLY A  67
SER A  23
 None
 1.29A 4xp9C-4u8gA:
undetectable		 4xp9C-4u8gA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 4u8g PUTATIVE
UNCHARACTERIZED
PROTEIN GBS1891
(Streptococcus
agalactiae) 		5 / 12 ASP A  71
GLY A  21
ILE A  19
VAL A  82
ILE A  78
 None
 0.87A 5kqxA-4u8gA:
undetectable		 5kqxA-4u8gA:
18.55