SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u8h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)
4u8h CRYPTOCHROME-2
(Mus
musculus)
3 / 3 ALA A 247
VAL A 249
TRP A 248
None
0.92A 1bdwA-4u8hA:
undetectable
1bdwB-4u8hA:
undetectable
1bdwA-4u8hA:
3.08
1bdwB-4u8hA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)
4u8h CRYPTOCHROME-2
(Mus
musculus)
4 / 4 ARG A  32
ALA A 187
ALA A  38
GLU A 117
None
1.13A 1e7bA-4u8hA:
undetectable
1e7bA-4u8hA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)
4u8h CRYPTOCHROME-2
(Mus
musculus)
4 / 4 ARG A  32
ALA A 187
ALA A  38
GLU A 117
None
1.13A 1e7bB-4u8hA:
undetectable
1e7bB-4u8hA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)
4u8h CRYPTOCHROME-2
PERIOD CIRCADIAN
PROTEIN HOMOLOG 2

(Mus
musculus)
4 / 7 PHE A 355
GLN B1154
TRP A 466
ASN A 490
None
1.31A 1jqdA-4u8hA:
undetectable
1jqdA-4u8hA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)
4u8h CRYPTOCHROME-2
(Mus
musculus)
3 / 3 ARG A  28
GLY A 124
ASP A 128
None
0.35A 1kf6A-4u8hA:
undetectable
1kf6B-4u8hA:
undetectable
1kf6A-4u8hA:
21.95
1kf6B-4u8hA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)
4u8h CRYPTOCHROME-2
(Mus
musculus)
5 / 11 GLU A 401
GLY A  66
GLU A 215
LEU A 216
PRO A  57
None
1.42A 1mjqA-4u8hA:
undetectable
1mjqB-4u8hA:
undetectable
1mjqA-4u8hA:
12.08
1mjqB-4u8hA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)
4u8h CRYPTOCHROME-2
(Mus
musculus)
5 / 12 ASP A  56
PRO A 211
GLY A 217
ALA A  60
ALA A  61
None
1.18A 1nw5A-4u8hA:
2.3
1nw5A-4u8hA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)
4u8h CRYPTOCHROME-2
(Mus
musculus)
5 / 10 ASP A 339
ARG A 501
LEU A 497
VAL A 489
ILE A 488
None
1.38A 1q6iB-4u8hA:
undetectable
1q6iB-4u8hA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
4u8h CRYPTOCHROME-2
(Mus
musculus)
5 / 11 TYR A 272
GLY A 230
SER A  76
LEU A  31
ALA A 226
None
1.31A 2a58A-4u8hA:
2.6
2a58E-4u8hA:
2.6
2a58A-4u8hA:
15.07
2a58E-4u8hA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
4u8h CRYPTOCHROME-2
(Mus
musculus)
5 / 11 ALA A 226
TYR A 272
GLY A 230
SER A  76
LEU A  31
None
1.31A 2a58C-4u8hA:
2.4
2a58D-4u8hA:
2.4
2a58C-4u8hA:
15.07
2a58D-4u8hA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)
4u8h CRYPTOCHROME-2
PERIOD CIRCADIAN
PROTEIN HOMOLOG 2

(Mus
musculus;
Mus
musculus)
3 / 3 CYH A 432
CYH B1213
HIS A 491
ZN  A2000 (-2.7A)
ZN  A2000 (-4.2A)
ZN  A2000 (-3.3A)
0.74A 2iwkA-4u8hA:
undetectable
2iwkA-4u8hA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)
4u8h CRYPTOCHROME-2
PERIOD CIRCADIAN
PROTEIN HOMOLOG 2

(Mus
musculus;
Mus
musculus)
3 / 3 CYH A 432
CYH B1213
HIS A 491
ZN  A2000 (-2.7A)
ZN  A2000 (-4.2A)
ZN  A2000 (-3.3A)
0.75A 2iwkB-4u8hA:
undetectable
2iwkB-4u8hA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
4u8h CRYPTOCHROME-2
(Mus
musculus)
5 / 6 PHE A 355
ILE A 358
TRP A 466
GLY A 435
GLY A 437
None
1.44A 2qx6A-4u8hA:
undetectable
2qx6B-4u8hA:
undetectable
2qx6A-4u8hA:
17.06
2qx6B-4u8hA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)
4u8h CRYPTOCHROME-2
(Mus
musculus)
3 / 3 TRP A 338
GLN A 335
TRP A 417
None
0.99A 2vqyA-4u8hA:
undetectable
2vqyA-4u8hA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)
4u8h CRYPTOCHROME-2
PERIOD CIRCADIAN
PROTEIN HOMOLOG 2

(Mus
musculus;
Mus
musculus)
3 / 3 CYH A 432
CYH B1213
HIS A 491
ZN  A2000 (-2.7A)
ZN  A2000 (-4.2A)
ZN  A2000 (-3.3A)
0.85A 3dtuB-4u8hA:
undetectable
3dtuB-4u8hA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)
4u8h CRYPTOCHROME-2
PERIOD CIRCADIAN
PROTEIN HOMOLOG 2

(Mus
musculus;
Mus
musculus)
3 / 3 CYH A 432
CYH B1213
HIS A 491
ZN  A2000 (-2.7A)
ZN  A2000 (-4.2A)
ZN  A2000 (-3.3A)
0.83A 3dtuD-4u8hA:
undetectable
3dtuD-4u8hA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)
4u8h CRYPTOCHROME-2
(Mus
musculus)
4 / 8 GLY A 386
CYH A 333
PHE A 423
PHE A 427
None
1.06A 3ko0D-4u8hA:
undetectable
3ko0E-4u8hA:
undetectable
3ko0D-4u8hA:
11.93
3ko0E-4u8hA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)
4u8h CRYPTOCHROME-2
(Mus
musculus)
4 / 8 PHE A 427
GLY A 386
CYH A 333
PHE A 423
None
1.02A 3ko0B-4u8hA:
undetectable
3ko0J-4u8hA:
undetectable
3ko0B-4u8hA:
11.93
3ko0J-4u8hA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)
4u8h CRYPTOCHROME-2
(Mus
musculus)
4 / 7 PHE A 427
GLY A 386
CYH A 333
PHE A 423
None
1.09A 3ko0K-4u8hA:
undetectable
3ko0S-4u8hA:
undetectable
3ko0K-4u8hA:
11.93
3ko0S-4u8hA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)
4u8h CRYPTOCHROME-2
(Mus
musculus)
4 / 7 PHE A 427
GLY A 386
CYH A 333
PHE A 423
None
1.11A 3ko0R-4u8hA:
undetectable
3ko0T-4u8hA:
undetectable
3ko0R-4u8hA:
11.93
3ko0T-4u8hA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
4u8h CRYPTOCHROME-2
(Mus
musculus)
3 / 3 PHE A  27
CYH A  51
HIS A  25
None
0.91A 3u9fF-4u8hA:
undetectable
3u9fF-4u8hA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
4u8h CRYPTOCHROME-2
(Mus
musculus)
3 / 3 PHE A  27
CYH A  51
HIS A  25
None
0.98A 3u9fG-4u8hA:
undetectable
3u9fG-4u8hA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
4u8h CRYPTOCHROME-2
(Mus
musculus)
3 / 3 PHE A  27
CYH A  51
HIS A  25
None
0.92A 3u9fL-4u8hA:
undetectable
3u9fL-4u8hA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
4u8h CRYPTOCHROME-2
(Mus
musculus)
3 / 3 PHE A  27
CYH A  51
HIS A  25
None
1.00A 3u9fS-4u8hA:
undetectable
3u9fS-4u8hA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)
4u8h CRYPTOCHROME-2
(Mus
musculus)
4 / 7 GLY A 413
ALA A 412
TRP A 415
ASP A 400
None
0.67A 3ur0B-4u8hA:
undetectable
3ur0B-4u8hA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)
4u8h CRYPTOCHROME-2
PERIOD CIRCADIAN
PROTEIN HOMOLOG 2

(Mus
musculus)
4 / 5 LEU A 213
LEU A 216
LEU B1134
SER A  64
None
1.04A 3vhuA-4u8hA:
undetectable
3vhuA-4u8hA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)
4u8h CRYPTOCHROME-2
(Mus
musculus)
4 / 6 LEU A 290
TYR A 291
LYS A 295
GLU A 253
None
1.11A 4f3tA-4u8hA:
undetectable
4f3tA-4u8hA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
4u8h CRYPTOCHROME-2
(Mus
musculus)
5 / 9 TRP A 466
GLY A 435
GLY A 437
PHE A 355
ILE A 358
None
1.43A 4fgjA-4u8hA:
undetectable
4fgjB-4u8hA:
undetectable
4fgjA-4u8hA:
17.03
4fgjB-4u8hA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
4u8h CRYPTOCHROME-2
(Mus
musculus)
5 / 12 ASP A  79
LEU A  80
LEU A 404
GLY A 276
LEU A 236
None
1.19A 4retA-4u8hA:
undetectable
4retA-4u8hA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
4u8h CRYPTOCHROME-2
(Mus
musculus)
5 / 12 ASP A  79
LEU A  80
LEU A 404
GLY A 276
LEU A 236
None
1.19A 4retC-4u8hA:
undetectable
4retC-4u8hA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)
4u8h CRYPTOCHROME-2
(Mus
musculus)
4 / 7 LEU A 290
TYR A 291
LYS A 295
GLU A 253
None
1.04A 4z4fA-4u8hA:
2.9
4z4fA-4u8hA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)
4u8h CRYPTOCHROME-2
(Mus
musculus)
4 / 6 LEU A 290
TYR A 291
LYS A 295
GLU A 253
None
1.09A 4z4gA-4u8hA:
3.0
4z4gA-4u8hA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)
4u8h CRYPTOCHROME-2
(Mus
musculus)
3 / 3 ASP A 119
ARG A 281
ARG A  32
None
0.97A 5eajB-4u8hA:
undetectable
5eajB-4u8hA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)
4u8h CRYPTOCHROME-2
PERIOD CIRCADIAN
PROTEIN HOMOLOG 2

(Mus
musculus;
Mus
musculus)
5 / 12 THR A 353
THR B1145
ALA B1143
GLY A 351
ALA A 349
None
1.15A 5lf7V-4u8hA:
undetectable
5lf7b-4u8hA:
undetectable
5lf7V-4u8hA:
17.35
5lf7b-4u8hA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)
4u8h CRYPTOCHROME-2
PERIOD CIRCADIAN
PROTEIN HOMOLOG 2

(Mus
musculus;
Mus
musculus)
5 / 12 THR A 353
THR B1145
ALA B1143
GLY A 351
ALA A 349
None
1.15A 5lf7H-4u8hA:
undetectable
5lf7N-4u8hA:
undetectable
5lf7H-4u8hA:
17.35
5lf7N-4u8hA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_F_ACTF503_0
(METHYL-VIOLOGEN
REDUCING HYDROGENASE
SUBUNIT A)
4u8h CRYPTOCHROME-2
PERIOD CIRCADIAN
PROTEIN HOMOLOG 2

(Mus
musculus;
Mus
musculus)
4 / 4 ARG A 501
VAL B1163
ASP A 339
LYS B1170
None
1.32A 5odcF-4u8hA:
0.0
5odcF-4u8hA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)
4u8h CRYPTOCHROME-2
(Mus
musculus)
3 / 3 GLY A 268
LEU A 269
HIS A 242
None
0.56A 5u63A-4u8hA:
undetectable
5u63A-4u8hA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)
4u8h CRYPTOCHROME-2
(Mus
musculus)
3 / 3 GLY A 268
LEU A 269
HIS A 242
None
0.58A 5u63B-4u8hA:
undetectable
5u63B-4u8hA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)
4u8h CRYPTOCHROME-2
(Mus
musculus)
5 / 12 GLY A 413
SER A 414
LEU A 418
TYR A 168
PHE A 313
None
1.50A 5vlmF-4u8hA:
1.5
5vlmF-4u8hA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)
4u8h CRYPTOCHROME-2
PERIOD CIRCADIAN
PROTEIN HOMOLOG 2

(Mus
musculus;
Mus
musculus)
5 / 12 THR A 353
THR B1145
ALA B1143
GLY A 351
ALA A 349
None
1.09A 6hwdV-4u8hA:
undetectable
6hwdb-4u8hA:
undetectable
6hwdV-4u8hA:
10.66
6hwdb-4u8hA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)
4u8h CRYPTOCHROME-2
PERIOD CIRCADIAN
PROTEIN HOMOLOG 2

(Mus
musculus;
Mus
musculus)
5 / 12 THR A 353
THR B1145
ALA B1143
GLY A 351
ALA A 349
None
1.09A 6hwdH-4u8hA:
undetectable
6hwdN-4u8hA:
undetectable
6hwdH-4u8hA:
10.66
6hwdN-4u8hA:
8.43