SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u8u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4u8u GLOBIN C CHAIN
(Glossoscolex
paulistus) 		5 / 12 VAL C 106
GLY C 143
ALA C 146
SER C 147
LEU C 149
 HEM  C 201 (-4.2A)
None
None
None
None
 1.03A 1eqhA-4u8uC:
undetectable		 1eqhA-4u8uC:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 4u8u GLOBIN B CHAIN
GLOBIN C CHAIN
(Glossoscolex
paulistus;
Glossoscolex
paulistus) 		4 / 5 HIS B  90
GLU B  87
ALA B  83
SER C  66
 HEM  C 201 (-4.2A)
None
None
None
 1.19A 1errA-4u8uB:
undetectable
1errB-4u8uB:
undetectable		 1errA-4u8uB:
18.90
1errB-4u8uB:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 4u8u GLOBIN A CHAIN
(Glossoscolex
paulistus) 		4 / 8 PHE A 137
LEU A  95
LEU A  75
LEU A  92
 HEM  A 201 (-4.8A)
HEM  A 201 (-4.9A)
HEM  A 201 ( 4.7A)
None
 0.88A 1eupA-4u8uA:
undetectable		 1eupA-4u8uA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 4u8u LINKER L1
(Glossoscolex
paulistus) 		5 / 12 ILE M 208
LEU M 214
LEU M 180
GLY M 181
TYR M 170
 None
 1.07A 1hvyD-4u8uM:
undetectable		 1hvyD-4u8uM:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4u8u GLOBIN B CHAIN
GLOBIN C CHAIN
(Glossoscolex
paulistus;
Glossoscolex
paulistus) 		5 / 12 TYR B  19
GLY B  22
ASP C  84
SER B  20
LEU C  73
 None
 1.40A 1kiaD-4u8uB:
undetectable		 1kiaD-4u8uB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4u8u GLOBIN A CHAIN
(Glossoscolex
paulistus) 		5 / 10 VAL A 124
LEU A  68
VAL A  36
GLY A  34
ALA A  35
 None
 1.24A 1pxxD-4u8uA:
undetectable		 1pxxD-4u8uA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 4u8u GLOBIN C CHAIN
(Glossoscolex
paulistus) 		4 / 7 ASN C 130
TYR C 129
LEU C 126
GLN C  16
 None
 1.05A 1qzrA-4u8uC:
undetectable		 1qzrA-4u8uC:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 4u8u GLOBIN C CHAIN
(Glossoscolex
paulistus) 		4 / 7 ASN C 130
TYR C 129
LEU C 126
GLN C  16
 None
 0.90A 1qzrB-4u8uC:
undetectable		 1qzrB-4u8uC:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4u8u GLOBIN A CHAIN
GLOBIN B CHAIN
(Glossoscolex
paulistus;
Glossoscolex
paulistus) 		3 / 3 LYS B  12
ASP A  60
ASP B  79
 None
 1.00A 2br4D-4u8uB:
undetectable		 2br4D-4u8uB:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4u8u LINKER L2
LINKER L3
(Glossoscolex
paulistus;
Glossoscolex
paulistus) 		4 / 6 ARG N  60
ASP O 190
ASN O 193
ASP O 195
 None
 1.25A 2okcA-4u8uN:
undetectable		 2okcA-4u8uN:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4u8u GLOBIN B CHAIN
(Glossoscolex
paulistus) 		4 / 5 GLN B 119
PHE B  28
TRP B  15
GLY B  22
 None
 1.20A 2qmzA-4u8uB:
undetectable
2qmzB-4u8uB:
undetectable		 2qmzA-4u8uB:
22.13
2qmzB-4u8uB:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 4u8u GLOBIN B CHAIN
GLOBIN C CHAIN
(Glossoscolex
paulistus) 		4 / 8 ARG B  16
LYS B  12
SER C  27
ASP B  79
 None
 1.34A 2rk8A-4u8uB:
undetectable		 2rk8A-4u8uB:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 4u8u GLOBIN B CHAIN
GLOBIN C CHAIN
(Glossoscolex
paulistus) 		4 / 7 ARG B  16
LYS B  12
SER C  27
ASP B  79
 None
 1.34A 2rk8B-4u8uB:
undetectable		 2rk8B-4u8uB:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 4u8u GLOBIN C CHAIN
(Glossoscolex
paulistus) 		5 / 10 ASP C 127
ILE C  80
PHE C  33
ILE C 141
GLY C 121
 None
 1.38A 2v0mA-4u8uC:
undetectable		 2v0mA-4u8uC:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_B_FK5B501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 4u8u LINKER L1
(Glossoscolex
paulistus) 		5 / 10 ASP M 201
ARG M 176
VAL M 147
ILE M 132
PHE M 111
 None
 1.28A 2vn1B-4u8uM:
undetectable		 2vn1B-4u8uM:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 4u8u GLOBIN C CHAIN
(Glossoscolex
paulistus) 		5 / 12 ILE C 114
ASN C  74
LEU C 142
ILE C 145
ALA C 146
 HEM  C 201 (-3.6A)
None
HEM  C 201 (-4.8A)
None
None
 1.13A 3a50A-4u8uC:
undetectable		 3a50A-4u8uC:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 4u8u LINKER L1
LINKER L2
(Glossoscolex
paulistus) 		3 / 3 GLU N  82
HIS M 126
HIS M 127
 None
 0.51A 3co4A-4u8uN:
undetectable		 3co4A-4u8uN:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 4u8u GLOBIN C CHAIN
(Glossoscolex
paulistus) 		5 / 12 LEU C  70
LEU C  73
ASN C  74
LEU C  76
LEU C  20
 None
None
None
HEM  C 201 ( 4.4A)
None
 1.33A 3d90B-4u8uC:
undetectable		 3d90B-4u8uC:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FGR_B_ACTB21_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM)		 4u8u LINKER L1
(Glossoscolex
paulistus) 		4 / 4 ARG M 176
ASP M 200
ASP M 201
PRO M 104
 None
 1.21A 3fgrB-4u8uM:
undetectable		 3fgrB-4u8uM:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FGR_B_ACTB21_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM)		 4u8u LINKER L1
(Glossoscolex
paulistus) 		4 / 4 ARG M 176
ASP M 202
ASP M 201
PRO M 104
 None
 1.34A 3fgrB-4u8uM:
undetectable		 3fgrB-4u8uM:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4u8u LINKER L1
LINKER L2
(Glossoscolex
paulistus;
Glossoscolex
paulistus) 		4 / 7 GLY M 218
GLN M 207
VAL M 216
GLN N  81
 None
 0.89A 3fi0P-4u8uM:
undetectable		 3fi0P-4u8uM:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 4u8u LINKER L1
(Glossoscolex
paulistus) 		5 / 10 ASP M 201
ARG M 176
VAL M 147
ILE M 132
PHE M 111
 None
 1.45A 3ihzA-4u8uM:
undetectable		 3ihzA-4u8uM:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4u8u LINKER L3
(Glossoscolex
paulistus) 		5 / 12 GLY O 199
ASP O 112
ILE O 201
THR O 115
LEU O 185
 None
 1.11A 3iv6A-4u8uO:
undetectable		 3iv6A-4u8uO:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4u8u GLOBIN A CHAIN
(Glossoscolex
paulistus) 		5 / 12 LEU A  75
LEU A  95
TRP A 133
PHE A 117
ILE A 113
 HEM  A 201 ( 4.7A)
HEM  A 201 (-4.9A)
None
HEM  A 201 (-4.6A)
HEM  A 201 (-3.6A)
 1.25A 3kk6B-4u8uA:
undetectable		 3kk6B-4u8uA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4u8u GLOBIN B CHAIN
GLOBIN C CHAIN
(Glossoscolex
paulistus;
Glossoscolex
paulistus) 		4 / 4 GLY C  62
GLU C  61
ASP C  58
ASP B  82
 None
 1.21A 3mb5A-4u8uC:
2.3		 3mb5A-4u8uC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 4u8u LINKER L1
(Glossoscolex
paulistus) 		5 / 9 VAL M 115
ILE M 208
PHE M 153
ALA M 152
VAL M 192
 None
 1.11A 3me6C-4u8uM:
undetectable		 3me6C-4u8uM:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4u8u GLOBIN A CHAIN
GLOBIN B CHAIN
(Glossoscolex
paulistus) 		5 / 12 VAL B   5
LEU A  68
ILE A  32
GLY A  34
ALA A  35
 None
 1.07A 3n8zB-4u8uB:
undetectable		 3n8zB-4u8uB:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 4u8u GLOBIN B CHAIN
GLOBIN C CHAIN
(Glossoscolex
paulistus) 		4 / 8 PRO C  86
PRO B  58
GLN B  61
GLU B  59
 None
 1.03A 3oyaA-4u8uC:
undetectable		 3oyaA-4u8uC:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 4u8u GLOBIN C CHAIN
LINKER L1
(Glossoscolex
paulistus;
Glossoscolex
paulistus) 		3 / 3 ASP C  84
GLU M  66
SER C   6
 None
 0.85A 3p2kA-4u8uC:
undetectable		 3p2kA-4u8uC:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 4u8u GLOBIN B CHAIN
LINKER L1
(Glossoscolex
paulistus) 		5 / 12 ASP M  79
GLY M  92
GLY M  85
ASP M  84
ASP B  27
 None
None
None
CA  M 301 (-3.1A)
None
 1.07A 3prsA-4u8uM:
undetectable		 3prsA-4u8uM:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 4u8u GLOBIN A CHAIN
(Glossoscolex
paulistus) 		4 / 6 ILE A  79
LEU A  75
PHE A 117
GLY A 114
 None
HEM  A 201 ( 4.7A)
HEM  A 201 (-4.6A)
None
 1.02A 3sj1X-4u8uA:
undetectable		 3sj1X-4u8uA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 4u8u LINKER L3
(Glossoscolex
paulistus) 		4 / 7 PHE O  99
PHE O 197
PHE O 105
LEU O 185
 None
 1.01A 3t3sC-4u8uO:
undetectable		 3t3sC-4u8uO:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4u8u LINKER L1
(Glossoscolex
paulistus) 		5 / 10 ASP M 201
ARG M 176
VAL M 147
ILE M 132
PHE M 111
 None
 1.39A 3uf8A-4u8uM:
undetectable		 3uf8A-4u8uM:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4u8u LINKER L1
(Glossoscolex
paulistus) 		5 / 10 ASP M 201
ARG M 176
VAL M 147
ILE M 132
PHE M 111
 None
 1.45A 3uqaA-4u8uM:
undetectable		 3uqaA-4u8uM:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 4u8u LINKER L2
(Glossoscolex
paulistus) 		3 / 3 GLU N 219
GLY N 220
SER N 199
 None
 0.70A 4b53B-4u8uN:
undetectable		 4b53B-4u8uN:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 4u8u GLOBIN A CHAIN
(Glossoscolex
paulistus) 		5 / 12 VAL A 124
LEU A  68
VAL A  36
GLY A  34
ALA A  35
 None
 1.15A 4coxA-4u8uA:
undetectable		 4coxA-4u8uA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 4u8u GLOBIN A CHAIN
(Glossoscolex
paulistus) 		5 / 12 VAL A 124
LEU A  68
VAL A  36
GLY A  34
ALA A  35
 None
 1.15A 4coxB-4u8uA:
undetectable		 4coxB-4u8uA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 4u8u GLOBIN A CHAIN
(Glossoscolex
paulistus) 		5 / 12 VAL A 124
LEU A  68
VAL A  36
GLY A  34
ALA A  35
 None
 1.16A 4coxD-4u8uA:
undetectable		 4coxD-4u8uA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4u8u LINKER L2
(Glossoscolex
paulistus) 		3 / 3 PHE N 181
ASP N  86
ARG N 151
 None
 0.43A 4eahF-4u8uN:
undetectable		 4eahF-4u8uN:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4u8u LINKER L2
(Glossoscolex
paulistus) 		3 / 3 PHE N 181
ASP N  86
ARG N 151
 None
 0.43A 4eahG-4u8uN:
undetectable		 4eahG-4u8uN:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4u8u GLOBIN A CHAIN
(Glossoscolex
paulistus) 		4 / 8 GLY A  34
TYR A  64
LEU A  68
VAL A  71
 None
None
None
HEM  A 201 ( 4.3A)
 0.73A 4fgzB-4u8uA:
undetectable		 4fgzB-4u8uA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4u8u LINKER L2
(Glossoscolex
paulistus) 		4 / 6 ILE N 158
VAL N 217
SER N 160
ASP N 203
 None
 1.13A 4iaqA-4u8uN:
undetectable		 4iaqA-4u8uN:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 4u8u GLOBIN C CHAIN
(Glossoscolex
paulistus) 		4 / 9 PHE C 111
HIS C 100
PHE C  52
ILE C  45
 HEM  C 201 (-3.7A)
HEM  C 201 (-3.2A)
HEM  C 201 (-4.5A)
None
 1.08A 4jvlA-4u8uC:
undetectable		 4jvlA-4u8uC:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4u8u GLOBIN A CHAIN
(Glossoscolex
paulistus) 		5 / 12 VAL A 124
LEU A  68
VAL A  36
GLY A  34
ALA A  35
 None
 1.10A 4otyA-4u8uA:
undetectable		 4otyA-4u8uA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4u8u GLOBIN C CHAIN
(Glossoscolex
paulistus) 		5 / 10 VAL C 106
GLY C 143
ALA C 146
SER C 147
LEU C 149
 HEM  C 201 (-4.2A)
None
None
None
None
 1.08A 4ph9A-4u8uC:
undetectable		 4ph9A-4u8uC:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4u8u GLOBIN C CHAIN
(Glossoscolex
paulistus) 		5 / 10 VAL C 106
GLY C 143
ALA C 146
SER C 147
LEU C 149
 HEM  C 201 (-4.2A)
None
None
None
None
 1.10A 4ph9B-4u8uC:
undetectable		 4ph9B-4u8uC:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 4u8u GLOBIN B CHAIN
GLOBIN C CHAIN
(Glossoscolex
paulistus) 		3 / 3 GLN B  94
HIS B  90
ARG C  71
 HEM  B 201 ( 3.6A)
HEM  C 201 (-4.2A)
None
 1.13A 4qyqA-4u8uB:
undetectable		 4qyqA-4u8uB:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 4u8u GLOBIN B CHAIN
GLOBIN C CHAIN
(Glossoscolex
paulistus) 		3 / 3 GLN C  99
HIS C  95
ARG B  66
 HEM  C 201 ( 3.6A)
HEM  B 201 (-4.1A)
HEM  B 201 (-4.8A)
 1.23A 4qyqA-4u8uC:
undetectable		 4qyqA-4u8uC:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 4u8u GLOBIN B CHAIN
GLOBIN C CHAIN
(Glossoscolex
paulistus) 		3 / 3 GLN B  94
HIS B  90
ARG C  71
 HEM  B 201 ( 3.6A)
HEM  C 201 (-4.2A)
None
 1.14A 4qyqB-4u8uB:
undetectable		 4qyqB-4u8uB:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4u8u GLOBIN A CHAIN
(Glossoscolex
paulistus) 		5 / 12 VAL A 124
LEU A  68
VAL A  36
GLY A  34
ALA A  35
 None
 1.09A 4rrwC-4u8uA:
undetectable		 4rrwC-4u8uA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4u8u GLOBIN A CHAIN
(Glossoscolex
paulistus) 		5 / 12 VAL A 124
LEU A  68
VAL A  36
GLY A  34
ALA A  35
 None
 1.09A 4rrzC-4u8uA:
undetectable		 4rrzC-4u8uA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4u8u GLOBIN B CHAIN
GLOBIN C CHAIN
(Glossoscolex
paulistus) 		4 / 5 SER C  79
ARG C  71
GLY B  70
GLU B  87
 None
None
HEM  B 201 ( 4.4A)
None
 1.19A 5btiA-4u8uC:
undetectable
5btiB-4u8uC:
undetectable		 5btiA-4u8uC:
15.51
5btiB-4u8uC:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4u8u GLOBIN B CHAIN
GLOBIN C CHAIN
(Glossoscolex
paulistus) 		4 / 5 SER C  79
ARG C  71
GLY B  70
GLU B  87
 None
None
HEM  B 201 ( 4.4A)
None
 1.18A 5btiC-4u8uC:
undetectable
5btiD-4u8uC:
undetectable		 5btiC-4u8uC:
15.51
5btiD-4u8uC:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4u8u GLOBIN A CHAIN
GLOBIN B CHAIN
(Glossoscolex
paulistus) 		4 / 7 VAL B   5
LEU A  68
GLY A  34
ALA A  35
 None
 0.84A 5f1aB-4u8uB:
undetectable		 5f1aB-4u8uB:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 4u8u LINKER L1
(Glossoscolex
paulistus) 		5 / 11 ASP M 201
ARG M 176
VAL M 147
ILE M 132
PHE M 111
 None
 1.40A 5huaA-4u8uM:
undetectable		 5huaA-4u8uM:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 4u8u GLOBIN C CHAIN
(Glossoscolex
paulistus) 		5 / 12 PHE C 111
LEU C  38
LEU C 142
ALA C  75
LEU C  73
 HEM  C 201 (-3.7A)
CYN  C 202 (-4.7A)
HEM  C 201 (-4.8A)
HEM  C 201 (-3.6A)
None
 1.06A 5ienB-4u8uC:
3.5		 5ienB-4u8uC:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4u8u GLOBIN A CHAIN
(Glossoscolex
paulistus) 		5 / 12 PHE A  41
ALA A  47
LEU A  50
ILE A 113
LEU A  68
 None
HEM  A 201 ( 3.8A)
HEM  A 201 (-4.0A)
HEM  A 201 (-3.6A)
None
 1.14A 5ljcA-4u8uA:
undetectable		 5ljcA-4u8uA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHD_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4u8u LINKER L1
(Glossoscolex
paulistus) 		4 / 4 ARG M 176
PHE M 196
ASP M 205
LEU M  50
 None
 1.05A 5uhdC-4u8uM:
undetectable		 5uhdC-4u8uM:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4u8u LINKER L2
(Glossoscolex
paulistus) 		3 / 3 ARG N 130
PHE N 173
ARG N 216
 None
 0.98A 5y9yA-4u8uN:
undetectable		 5y9yA-4u8uN:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 4u8u LINKER L2
(Glossoscolex
paulistus) 		4 / 8 ASN N 116
PHE N 118
PHE N 204
VAL N 154
 None
 1.12A 6huoC-4u8uN:
2.9
6huoD-4u8uN:
2.6		 6huoC-4u8uN:
13.98
6huoD-4u8uN:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 4u8u GLOBIN C CHAIN
(Glossoscolex
paulistus) 		5 / 11 ILE C 114
HIS C 100
ALA C  75
PHE C 111
ALA C 146
 HEM  C 201 (-3.6A)
HEM  C 201 (-3.2A)
HEM  C 201 (-3.6A)
HEM  C 201 (-3.7A)
None
 1.28A 6ieyA-4u8uC:
undetectable
6ieyB-4u8uC:
undetectable		 6ieyA-4u8uC:
17.08
6ieyB-4u8uC:
17.08