SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u90'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)
4u90 GEPHYRIN
(Rattus
norvegicus)
5 / 10 LEU A 586
LEU A 555
LEU A 554
ILE A 568
LEU A 612
None
1.27A 1pcgA-4u90A:
undetectable
1pcgA-4u90A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)
4u90 GEPHYRIN
(Rattus
norvegicus)
4 / 7 MET A 504
VAL A 501
THR A 541
ARG A 564
None
1.11A 2kotA-4u90A:
undetectable
2kotA-4u90A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
5 / 12 CYH A 676
LEU A 710
ALA A 689
ASN A 707
ILE A 677
None
1.01A 3a35A-4u90A:
undetectable
3a35A-4u90A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
5 / 12 CYH A 676
LEU A 710
ALA A 689
ASN A 707
ILE A 677
None
0.99A 3a35B-4u90A:
undetectable
3a35B-4u90A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
5 / 12 CYH A 676
LEU A 710
ALA A 689
ASN A 707
ILE A 677
None
1.03A 3a3bA-4u90A:
undetectable
3a3bA-4u90A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)
4u90 GEPHYRIN
(Rattus
norvegicus)
3 / 3 HIS A 682
GLU A 684
HIS A 681
None
0.88A 3ba0A-4u90A:
3.5
3ba0A-4u90A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)
4u90 GEPHYRIN
(Rattus
norvegicus)
4 / 5 VAL A 639
VAL A 640
THR A 541
THR A 634
None
1.26A 3bjwG-4u90A:
undetectable
3bjwG-4u90A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
4 / 6 LYS A 362
ALA A 361
LEU A 365
VAL A 359
None
0.97A 3d2tB-4u90A:
undetectable
3d2tB-4u90A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
4u90 GEPHYRIN
(Rattus
norvegicus)
5 / 11 GLY A 406
PHE A 388
ASP A 382
ALA A 381
ALA A 423
None
None
BU1  A 801 ( 4.6A)
None
None
1.07A 3g88A-4u90A:
undetectable
3g88A-4u90A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
4u90 GEPHYRIN
(Rattus
norvegicus)
5 / 11 GLY A 406
PHE A 388
ASP A 382
ALA A 381
ALA A 451
None
None
BU1  A 801 ( 4.6A)
None
BU1  A 801 ( 3.2A)
0.88A 3g88A-4u90A:
undetectable
3g88A-4u90A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
4u90 GEPHYRIN
(Rattus
norvegicus)
5 / 11 GLY A 406
PHE A 388
ASP A 382
ALA A 381
ALA A 423
None
None
BU1  A 801 ( 4.6A)
None
None
1.09A 3g88B-4u90A:
undetectable
3g88B-4u90A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
4u90 GEPHYRIN
(Rattus
norvegicus)
5 / 11 GLY A 406
PHE A 388
ASP A 382
ALA A 381
ALA A 451
None
None
BU1  A 801 ( 4.6A)
None
BU1  A 801 ( 3.2A)
0.90A 3g88B-4u90A:
undetectable
3g88B-4u90A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
4u90 GEPHYRIN
(Rattus
norvegicus)
5 / 12 GLY A 406
PHE A 388
ASP A 382
ALA A 381
ALA A 423
None
None
BU1  A 801 ( 4.6A)
None
None
1.02A 3g89A-4u90A:
undetectable
3g89A-4u90A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
4u90 GEPHYRIN
(Rattus
norvegicus)
5 / 12 GLY A 406
PHE A 388
ASP A 382
ALA A 381
ALA A 451
None
None
BU1  A 801 ( 4.6A)
None
BU1  A 801 ( 3.2A)
0.79A 3g89A-4u90A:
undetectable
3g89A-4u90A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
4u90 GEPHYRIN
(Rattus
norvegicus)
5 / 11 GLY A 406
PHE A 388
ASP A 382
ALA A 381
ALA A 423
None
None
BU1  A 801 ( 4.6A)
None
None
1.03A 3g89B-4u90A:
undetectable
3g89B-4u90A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
4u90 GEPHYRIN
(Rattus
norvegicus)
5 / 11 GLY A 406
PHE A 388
ASP A 382
ALA A 381
ALA A 451
None
None
BU1  A 801 ( 4.6A)
None
BU1  A 801 ( 3.2A)
0.81A 3g89B-4u90A:
undetectable
3g89B-4u90A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
4u90 GEPHYRIN
(Rattus
norvegicus)
5 / 12 GLY A 406
PHE A 388
ASP A 382
ALA A 381
ALA A 423
None
None
BU1  A 801 ( 4.6A)
None
None
1.05A 3g8bA-4u90A:
undetectable
3g8bA-4u90A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
4u90 GEPHYRIN
(Rattus
norvegicus)
5 / 12 GLY A 406
PHE A 388
ASP A 382
ALA A 381
ALA A 451
None
None
BU1  A 801 ( 4.6A)
None
BU1  A 801 ( 3.2A)
0.84A 3g8bA-4u90A:
undetectable
3g8bA-4u90A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
4u90 GEPHYRIN
(Rattus
norvegicus)
5 / 12 GLY A 406
PHE A 388
ASP A 382
ALA A 381
ALA A 423
None
None
BU1  A 801 ( 4.6A)
None
None
1.08A 3g8bB-4u90A:
undetectable
3g8bB-4u90A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
4u90 GEPHYRIN
(Rattus
norvegicus)
5 / 12 GLY A 406
PHE A 388
ASP A 382
ALA A 381
ALA A 451
None
None
BU1  A 801 ( 4.6A)
None
BU1  A 801 ( 3.2A)
0.88A 3g8bB-4u90A:
undetectable
3g8bB-4u90A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
5 / 9 ASP A 422
ALA A 423
ILE A 447
GLY A 383
PRO A 405
None
None
BU1  A 801 ( 4.3A)
BU1  A 801 ( 3.6A)
None
1.07A 3u7sB-4u90A:
undetectable
3u7sB-4u90A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
5 / 9 ASP A 422
ALA A 423
ILE A 447
GLY A 383
PRO A 405
None
None
BU1  A 801 ( 4.3A)
BU1  A 801 ( 3.6A)
None
1.09A 3u7sA-4u90A:
undetectable
3u7sA-4u90A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)
4u90 GEPHYRIN
(Rattus
norvegicus)
5 / 12 LEU A 586
LEU A 555
LEU A 554
ILE A 568
LEU A 612
None
1.13A 4j24A-4u90A:
undetectable
4j24A-4u90A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)
4u90 GEPHYRIN
(Rattus
norvegicus)
5 / 12 ASN A 543
GLU A 560
GLY A 561
ILE A 562
ILE A 621
None
1.45A 4xucA-4u90A:
undetectable
4xucA-4u90A:
18.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ERS_A_ACTA803_0
(GEPHYRIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
3 / 3 THR A 342
ALA A 356
ASN A 496
None
0.11A 5ersA-4u90A:
51.1
5ersA-4u90A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)
4u90 GEPHYRIN
(Rattus
norvegicus)
4 / 5 PHE A 638
VAL A 574
PRO A 603
MET A 601
None
1.25A 6ekzA-4u90A:
undetectable
6ekzA-4u90A:
12.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FGC_A_ACTA811_0
(GEPHYRIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
3 / 3 LEU A 323
LEU A 605
ARG A 670
None
0.33A 6fgcA-4u90A:
51.0
6fgcA-4u90A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FGC_A_ACTA813_0
(GEPHYRIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
3 / 3 THR A 342
ALA A 356
LYS A 473
None
0.09A 6fgcA-4u90A:
51.0
6fgcA-4u90A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FGC_A_D95A816_0
(GEPHYRIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
10 / 11 ASP A 327
PHE A 330
ILE A 331
LEU A 334
LEU A 637
ARG A 653
PRO A 654
ILE A 656
MET A 711
MET A 731
None
0.39A 6fgcA-4u90A:
51.0
6fgcA-4u90A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FGC_A_D95A816_0
(GEPHYRIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
10 / 11 MET A 326
ASP A 327
PHE A 330
ILE A 331
LEU A 334
LEU A 637
PRO A 654
ILE A 656
MET A 711
MET A 731
None
0.48A 6fgcA-4u90A:
51.0
6fgcA-4u90A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FGC_A_D95A816_0
(GEPHYRIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
5 / 11 PHE A 330
ILE A 331
LEU A 637
PRO A 641
MET A 731
None
1.39A 6fgcA-4u90A:
51.0
6fgcA-4u90A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FGD_A_ACTA806_0
(GEPHYRIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
4 / 4 MET A 351
GLY A 352
HIS A 476
GLY A 478
None
0.22A 6fgdA-4u90A:
50.7
6fgdA-4u90A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FGD_A_ACTA807_0
(GEPHYRIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
4 / 4 PRO A 338
LEU A 340
VAL A 617
ARG A 618
None
0.13A 6fgdA-4u90A:
50.7
6fgdA-4u90A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FGD_A_ACTA810_0
(GEPHYRIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
3 / 3 LEU A 323
LEU A 605
ARG A 670
None
0.39A 6fgdA-4u90A:
50.7
6fgdA-4u90A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FGD_A_ACTA812_0
(GEPHYRIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
6 / 6 GLU A 343
ARG A 353
LYS A 497
PHE A 498
VAL A 500
PRO A 540
None
0.22A 6fgdA-4u90A:
50.7
6fgdA-4u90A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FGD_A_ACTA817_0
(GEPHYRIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
3 / 3 THR A 342
ALA A 356
LYS A 473
None
0.15A 6fgdA-4u90A:
50.7
6fgdA-4u90A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FGD_A_ACTA819_0
(GEPHYRIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
3 / 3 ARG A 660
GLY A 725
GLU A 726
None
0.30A 6fgdA-4u90A:
50.7
6fgdA-4u90A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FGD_A_ACTA820_0
(GEPHYRIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
4 / 5 GLU A 397
PRO A 399
THR A 400
GLN A 401
None
0.89A 6fgdA-4u90A:
50.7
6fgdA-4u90A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FGD_A_ACTA820_0
(GEPHYRIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
4 / 5 PRO A 399
THR A 400
GLN A 401
MET A 409
None
0.17A 6fgdA-4u90A:
50.7
6fgdA-4u90A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FGD_A_ACTA821_0
(GEPHYRIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
3 / 3 ARG A 387
PHE A 388
GLY A 406
BU1  A 801 ( 4.3A)
None
None
0.17A 6fgdA-4u90A:
50.7
6fgdA-4u90A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FGD_A_ACTA824_0
(GEPHYRIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
4 / 4 LEU A 334
ASP A 651
PRO A 652
ARG A 653
None
0.28A 6fgdA-4u90A:
50.7
6fgdA-4u90A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FGD_A_ACTA825_0
(GEPHYRIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
3 / 3 LYS A 658
VAL A 727
ASP A 729
None
0.50A 6fgdA-4u90A:
50.7
6fgdA-4u90A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FGD_A_ACTA826_0
(GEPHYRIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
3 / 3 HIS A 476
ARG A 644
ILE A 649
None
0.09A 6fgdA-4u90A:
50.7
6fgdA-4u90A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FGD_A_ACTA827_0
(GEPHYRIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
4 / 4 LYS A 373
GLN A 426
GLN A 455
ASP A 456
None
0.46A 6fgdA-4u90A:
50.7
6fgdA-4u90A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FGD_A_D8ZA831_0
(GEPHYRIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
11 / 11 MET A 326
ASP A 327
PHE A 330
ILE A 331
LEU A 637
ARG A 653
PRO A 654
ILE A 656
TYR A 673
MET A 711
MET A 731
None
0.40A 6fgdA-4u90A:
50.7
6fgdA-4u90A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FGD_A_D8ZA831_0
(GEPHYRIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
7 / 11 MET A 326
ASP A 327
PHE A 330
ILE A 331
LEU A 637
PRO A 641
TYR A 673
None
1.45A 6fgdA-4u90A:
50.7
6fgdA-4u90A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_0
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)
4u90 GEPHYRIN
(Rattus
norvegicus)
5 / 12 PRO A 641
ILE A 331
THR A 607
PHE A 622
PHE A 609
None
1.49A 6hloA-4u90A:
0.0
6hloA-4u90A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)
4u90 GEPHYRIN
(Rattus
norvegicus)
5 / 12 PRO A 641
ILE A 331
THR A 607
PHE A 622
PHE A 609
None
1.42A 6j20A-4u90A:
undetectable
6j20A-4u90A:
19.92