SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u9c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		5 / 12 PHE A 317
LEU A  89
ALA A 325
VAL A 338
ARG A 327
 None
 1.13A 1cbrA-4u9cA:
undetectable		 1cbrA-4u9cA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		5 / 12 PHE A 317
LEU A  89
ALA A 325
VAL A 338
ARG A 327
 None
 1.12A 1cbrB-4u9cA:
undetectable		 1cbrB-4u9cA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		5 / 12 LEU A 312
PHE A 316
PHE A 339
GLY A 315
GLY A 279
 None
 1.12A 1fe2A-4u9cA:
undetectable		 1fe2A-4u9cA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		4 / 8 ALA A  46
ASP A  85
ILE A  86
ILE A 329
 None
 0.71A 1p7lD-4u9cA:
undetectable		 1p7lD-4u9cA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		4 / 8 ALA A  46
ASP A  85
ILE A  86
ILE A 329
 None
 0.71A 1p7lC-4u9cA:
undetectable		 1p7lC-4u9cA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		5 / 12 LEU A 249
ASN A 185
PHE A 282
LEU A 245
TYR A 182
 None
 1.46A 1pj7A-4u9cA:
undetectable		 1pj7A-4u9cA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		4 / 8 ALA A  46
ASP A  85
ILE A  86
ILE A 329
 None
 0.72A 1rg9B-4u9cA:
undetectable		 1rg9B-4u9cA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		4 / 8 ALA A  46
ASP A  85
ILE A  86
ILE A 329
 None
 0.73A 1rg9A-4u9cA:
undetectable		 1rg9A-4u9cA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		4 / 8 ALA A  46
ASP A  85
ILE A  86
ILE A 329
 None
 0.72A 1rg9D-4u9cA:
undetectable		 1rg9D-4u9cA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		4 / 8 ALA A  46
ASP A  85
ILE A  86
ILE A 329
 None
 0.71A 1rg9C-4u9cA:
undetectable		 1rg9C-4u9cA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		5 / 12 LEU A 100
ALA A  50
THR A 219
VAL A 338
VAL A 133
 None
 1.12A 2g78A-4u9cA:
2.4		 2g78A-4u9cA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		5 / 12 TYR A 188
ALA A 234
ALA A 340
GLY A 184
TYR A 221
 None
 1.13A 2igtC-4u9cA:
undetectable		 2igtC-4u9cA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		4 / 6 SER A 334
VAL A 288
TYR A 271
ASP A 332
 None
 1.37A 2x45A-4u9cA:
undetectable		 2x45A-4u9cA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_SAMA228_0
(CATECHOL
O-METHYLTRANSFERASE)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		5 / 10 GLY A 131
SER A 220
GLU A 120
SER A 166
GLN A  96
 None
 1.49A 3s68A-4u9cA:
undetectable		 3s68A-4u9cA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		5 / 10 ARG A 327
GLY A 326
LEU A 245
LEU A 312
ILE A 273
 None
 1.05A 3wdmB-4u9cA:
undetectable		 3wdmB-4u9cA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		5 / 10 ARG A 327
GLY A 326
LEU A 245
LEU A 312
ILE A 273
 None
 1.01A 3wdmD-4u9cA:
undetectable		 3wdmD-4u9cA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		4 / 5 THR A 269
ILE A 250
LYS A 248
GLU A 235
 None
 1.49A 4acbC-4u9cA:
undetectable		 4acbC-4u9cA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		4 / 8 ALA A  46
ASP A  85
ILE A  86
ILE A 329
 None
 0.83A 4ndnB-4u9cA:
undetectable		 4ndnB-4u9cA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		4 / 8 ALA A  46
ASP A  85
ILE A  86
ILE A 329
 None
 0.80A 4ndnD-4u9cA:
undetectable		 4ndnD-4u9cA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		5 / 12 LEU A  89
GLY A  48
ARG A 327
GLU A 120
LEU A 100
 None
 1.31A 5czyA-4u9cA:
undetectable		 5czyA-4u9cA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		4 / 6 LYS A 293
SER A 334
VAL A 335
ASP A 307
 None
 1.26A 5hesA-4u9cA:
undetectable		 5hesA-4u9cA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		4 / 6 GLU A 323
ALA A 234
LEU A 249
TYR A 165
 None
 1.05A 5igiA-4u9cA:
undetectable		 5igiA-4u9cA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		4 / 8 TYR A 182
PHE A 127
SER A 173
ASN A 320
 None
 0.95A 5l1fA-4u9cA:
undetectable
5l1fB-4u9cA:
undetectable		 5l1fA-4u9cA:
19.43
5l1fB-4u9cA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		4 / 8 ALA A  46
ASP A  85
ILE A  86
ILE A 329
 None
 0.75A 5t8sA-4u9cA:
undetectable		 5t8sA-4u9cA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4u9c LACTOFERRIN-BINDING
PROTEIN B
(Neisseria
meningitidis) 		4 / 7 ALA A  46
ASP A  85
ILE A  86
ILE A 329
 None
 0.92A 6fbnA-4u9cA:
undetectable		 6fbnA-4u9cA:
24.71