SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u9o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
(Vibrio
cholerae) 		5 / 9 PHE A 131
VAL A 180
GLY A 177
VAL A 151
ILE A 149
 None
 1.29A 2a1oB-4u9oA:
undetectable		 2a1oB-4u9oA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
(Vibrio
cholerae) 		4 / 6 THR A 258
ALA A 246
ARG A 260
PRO A  71
 None
 1.33A 2ql8A-4u9oA:
undetectable
2ql8B-4u9oA:
undetectable		 2ql8A-4u9oA:
17.91
2ql8B-4u9oA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
(Vibrio
cholerae) 		4 / 7 VAL A 165
ILE A 245
GLN A 242
LEU A 181
 None
 0.88A 3bjwH-4u9oA:
undetectable		 3bjwH-4u9oA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
(Vibrio
cholerae) 		5 / 10 LEU A 122
VAL A 244
VAL A 180
GLY A 177
TRP A 237
 None
 1.37A 3qipA-4u9oA:
undetectable		 3qipA-4u9oA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
(Vibrio
cholerae) 		4 / 5 PHE A 131
GLY A 177
ILE A 149
VAL A 189
 None
 0.78A 3wrkA-4u9oA:
undetectable		 3wrkA-4u9oA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
(Vibrio
cholerae) 		5 / 12 LEU A 181
VAL A 175
GLY A 177
ALA A 176
LEU A 252
 None
 1.06A 4coxA-4u9oA:
undetectable		 4coxA-4u9oA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
(Vibrio
cholerae) 		5 / 12 LEU A 181
VAL A 175
GLY A 177
ALA A 176
LEU A 252
 None
 1.08A 4coxB-4u9oA:
undetectable		 4coxB-4u9oA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
(Vibrio
cholerae) 		5 / 12 LEU A 181
VAL A 175
GLY A 177
ALA A 176
LEU A 252
 None
 1.09A 4coxD-4u9oA:
undetectable		 4coxD-4u9oA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
(Vibrio
cholerae) 		4 / 7 ILE A 239
ASP A 179
LEU A 178
GLY A 177
 None
 0.89A 4iqqB-4u9oA:
undetectable		 4iqqB-4u9oA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
(Vibrio
cholerae) 		4 / 7 ILE A 239
ASP A 179
LEU A 178
GLY A 177
 None
 0.79A 4iqqC-4u9oA:
undetectable		 4iqqC-4u9oA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
(Vibrio
cholerae) 		5 / 9 ASP A  49
VAL A  51
PRO A  71
VAL A  72
ILE A  92
 None
 1.15A 4ll3B-4u9oA:
undetectable		 4ll3B-4u9oA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
(Vibrio
cholerae) 		5 / 11 HIS A 320
GLY A 306
TYR A  36
TYR A 319
SER A 305
 None
 1.31A 4rv6A-4u9oA:
undetectable		 4rv6A-4u9oA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
(Vibrio
cholerae) 		5 / 11 HIS A 320
GLY A 306
TYR A  36
TYR A 319
SER A 305
 None
 1.30A 4rv6B-4u9oA:
undetectable		 4rv6B-4u9oA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
(Vibrio
cholerae) 		4 / 5 SER A 300
ALA A 309
HIS A 320
LEU A  32
 None
 1.26A 5dzkb-4u9oA:
undetectable
5dzkp-4u9oA:
undetectable		 5dzkb-4u9oA:
22.04
5dzkp-4u9oA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
(Vibrio
cholerae) 		4 / 5 SER A 300
ALA A 309
HIS A 320
LEU A  32
 None
 1.28A 5dzkc-4u9oA:
undetectable
5dzkq-4u9oA:
undetectable		 5dzkc-4u9oA:
22.04
5dzkq-4u9oA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
(Vibrio
cholerae) 		4 / 5 SER A 300
ALA A 309
HIS A 320
LEU A  32
 None
 1.32A 5dzkf-4u9oA:
undetectable
5dzkt-4u9oA:
undetectable		 5dzkf-4u9oA:
22.04
5dzkt-4u9oA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
(Vibrio
cholerae) 		4 / 6 SER A 300
ALA A 309
HIS A 320
LEU A  32
 None
 1.24A 5dzkg-4u9oA:
undetectable
5dzku-4u9oA:
undetectable		 5dzkg-4u9oA:
22.04
5dzku-4u9oA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
(Vibrio
cholerae) 		5 / 12 ILE A  92
VAL A  72
HIS A 313
VAL A 323
LEU A 316
 None
 1.22A 5ergB-4u9oA:
undetectable		 5ergB-4u9oA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
(Vibrio
cholerae) 		4 / 4 VAL A 123
LEU A 122
LEU A 127
ASP A 243
 None
 1.45A 5xv7A-4u9oA:
undetectable		 5xv7A-4u9oA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
(Vibrio
cholerae) 		3 / 3 ARG A 115
LYS A 119
ARG A 318
 None
 1.07A 6c06D-4u9oA:
undetectable		 6c06D-4u9oA:
undetectable