SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u9p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 4u9p UPF0264 PROTEIN
MJ1099
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 206
ILE A 194
ALA A 210
GLY A 209
ALA A 211
 None
 0.77A 1bx4A-4u9pA:
undetectable		 1bx4A-4u9pA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4u9p UPF0264 PROTEIN
MJ1099
(Methanocaldococc
us
jannaschii) 		3 / 3 LYS A  85
ASP A  22
CYH A 234
 None
 1.31A 2br4F-4u9pA:
undetectable		 2br4F-4u9pA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4u9p UPF0264 PROTEIN
MJ1099
(Methanocaldococc
us
jannaschii) 		4 / 4 ASP A 124
ASP A 162
ASP A 151
GLY A 157
 None
 1.05A 2igtC-4u9pA:
undetectable		 2igtC-4u9pA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4u9p UPF0264 PROTEIN
MJ1099
(Methanocaldococc
us
jannaschii) 		3 / 3 GLY A  32
GLY A  60
GLY A  35
 None
 0.33A 3bogC-4u9pA:
undetectable		 3bogC-4u9pA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4u9p UPF0264 PROTEIN
MJ1099
(Methanocaldococc
us
jannaschii) 		3 / 3 GLY A  32
GLY A  60
GLY A  35
 None
 0.27A 3bogD-4u9pA:
undetectable		 3bogD-4u9pA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4u9p UPF0264 PROTEIN
MJ1099
(Methanocaldococc
us
jannaschii) 		4 / 5 VAL A 128
THR A  58
GLY A  35
LYS A  27
 None
 0.87A 3elzB-4u9pA:
undetectable		 3elzB-4u9pA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4u9p UPF0264 PROTEIN
MJ1099
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 206
VAL A   5
ILE A   2
ALA A 186
LEU A 185
 None
 0.92A 3fpjA-4u9pA:
undetectable		 3fpjA-4u9pA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4u9p UPF0264 PROTEIN
MJ1099
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A   4
ASP A  25
THR A  58
GLY A 187
MET A 149
 None
 1.27A 3g1uD-4u9pA:
undetectable		 3g1uD-4u9pA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 4u9p UPF0264 PROTEIN
MJ1099
(Methanocaldococc
us
jannaschii) 		4 / 8 ASP A  25
SER A  56
LEU A 150
ASP A 151
 None
 0.94A 3m0wE-4u9pA:
undetectable
3m0wF-4u9pA:
undetectable
3m0wG-4u9pA:
undetectable
3m0wH-4u9pA:
undetectable		 3m0wE-4u9pA:
16.14
3m0wF-4u9pA:
16.14
3m0wG-4u9pA:
16.14
3m0wH-4u9pA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 4u9p UPF0264 PROTEIN
MJ1099
(Methanocaldococc
us
jannaschii) 		5 / 10 VAL A 147
ILE A 204
GLY A 206
ALA A 120
VAL A 118
 None
 0.96A 3t3cB-4u9pA:
undetectable		 3t3cB-4u9pA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4u9p UPF0264 PROTEIN
MJ1099
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  34
ALA A 184
VAL A 118
ALA A 120
ILE A 204
 None
 1.06A 4x1kD-4u9pA:
undetectable		 4x1kD-4u9pA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4u9p UPF0264 PROTEIN
MJ1099
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A 202
ALA A 184
VAL A 118
ALA A 120
ILE A 204
 None
 1.12A 4x1kD-4u9pA:
undetectable		 4x1kD-4u9pA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4u9p UPF0264 PROTEIN
MJ1099
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  34
ALA A 184
VAL A 118
ALA A 120
ILE A 204
 None
 1.00A 4x20B-4u9pA:
undetectable		 4x20B-4u9pA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 4u9p UPF0264 PROTEIN
MJ1099
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  69
LEU A 100
VAL A  59
GLY A  60
ASP A  61
 None
 1.16A 5nnaA-4u9pA:
undetectable		 5nnaA-4u9pA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 4u9p UPF0264 PROTEIN
MJ1099
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  69
LEU A 100
VAL A  59
GLY A  60
ASP A  61
 None
 1.20A 5nnaB-4u9pA:
undetectable		 5nnaB-4u9pA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 4u9p UPF0264 PROTEIN
MJ1099
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  69
LEU A 100
VAL A  59
GLY A  60
ASP A  61
 None
 1.21A 5nnaC-4u9pA:
1.9		 5nnaC-4u9pA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 4u9p UPF0264 PROTEIN
MJ1099
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  69
LEU A 100
VAL A  59
GLY A  60
ASP A  61
 None
 1.16A 5nnaD-4u9pA:
2.0		 5nnaD-4u9pA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 4u9p UPF0264 PROTEIN
MJ1099
(Methanocaldococc
us
jannaschii) 		4 / 6 TYR A 126
LEU A 150
GLU A 132
LEU A 134
 None
 1.43A 5xooA-4u9pA:
undetectable		 5xooA-4u9pA:
15.29