SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u9s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 4u9s NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
(Vibrio
cholerae) 		3 / 3 LEU C 221
LEU C 145
MET C 149
 None
FMN  C 301 (-4.4A)
None
 0.81A 1ya3B-4u9sC:
undetectable		 1ya3B-4u9sC:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 4u9s NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
(Vibrio
cholerae) 		4 / 8 GLY C 220
ILE C 205
ASN C 229
SER C 228
 None
 1.03A 2a8tB-4u9sC:
undetectable		 2a8tB-4u9sC:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 4u9s NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
(Vibrio
cholerae) 		3 / 3 LYS C 112
GLY C 245
PRO C 246
 None
 1.01A 2hreB-4u9sC:
undetectable		 2hreB-4u9sC:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4u9s NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
(Vibrio
cholerae) 		5 / 12 LEU C 256
VAL C 136
ALA C  88
LEU C 239
PHE C 244
 None
 1.32A 4iarA-4u9sC:
undetectable		 4iarA-4u9sC:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4u9s NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
(Vibrio
cholerae) 		3 / 3 ALA C  88
TYR C  91
PRO C 139
 None
 0.72A 4zdyA-4u9sC:
undetectable		 4zdyA-4u9sC:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4u9s NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
(Vibrio
cholerae) 		4 / 6 LYS C 135
GLU C 156
GLY C 159
ASP C 158
 None
 1.05A 5a06D-4u9sC:
undetectable		 5a06D-4u9sC:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 4u9s NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
(Vibrio
cholerae) 		5 / 12 LEU C 176
GLY C 177
GLY C 178
VAL C 180
LEU C 226
 FMN  C 301 (-4.1A)
FMN  C 301 (-3.1A)
None
None
FMN  C 301 (-3.6A)
 1.14A 5uc1B-4u9sC:
undetectable		 5uc1B-4u9sC:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u9s NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
(Vibrio
cholerae) 		4 / 8 SER C 103
ARG C 117
GLN C 110
ASN C 120
 None
 1.23A 5vunB-4u9sC:
undetectable		 5vunB-4u9sC:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u9s NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
(Vibrio
cholerae) 		4 / 8 SER C 103
ARG C 117
GLN C 110
ASN C 120
 None
 1.28A 5vuoB-4u9sC:
undetectable		 5vuoB-4u9sC:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4u9s NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
(Vibrio
cholerae) 		4 / 5 ILE C  49
PHE C  67
ARG C  74
THR C 133
 None
GOL  C 302 (-3.4A)
None
None
 1.24A 5z84N-4u9sC:
undetectable
5z84W-4u9sC:
undetectable		 5z84N-4u9sC:
17.51
5z84W-4u9sC:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u9s NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
(Vibrio
cholerae) 		4 / 8 SER C 103
ARG C 117
GLN C 110
ASN C 120
 None
 1.30A 6auuB-4u9sC:
undetectable		 6auuB-4u9sC:
19.91