SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u9u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2D55_C_DVAC8_0 (ACTINOMYCIN D)	4u9u	NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F (Vibrio cholerae)	3 / 3	PRO A 242 THR A 232 PRO A 234	FAD A1501 (-4.8A) None None	0.44A	2d55C-4u9uA: undetectable	2d55C-4u9uA: 2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KPC_A_SAMA1000_0 (UNCHARACTERIZED PROTEIN MJ0100)	4u9u	NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F (Vibrio cholerae)	5 / 11	ILE A 279 VAL A 387 ILE A 388 ASN A 400 ILE A 401	None	1.26A	3kpcA-4u9uA: undetectable	3kpcA-4u9uA: 18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W1W_B_CHDB502_0 (FERROCHELATASE, MITOCHONDRIAL)	4u9u	NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F (Vibrio cholerae)	5 / 9	ILE A 388 LEU A 391 PRO A 287 SER A 213 GLY A 280	None None None FAD A1501 (-3.1A) None	1.08A	3w1wB-4u9uA: 3.3	3w1wB-4u9uA: 22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MMD_A_29EA603_1 (TRANSPORTER)	4u9u	NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F (Vibrio cholerae)	5 / 10	PRO A 161 GLY A 166 PHE A 162 SER A 261 GLY A 262	None	1.23A	4mmdA-4u9uA: undetectable	4mmdA-4u9uA: 20.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4U9U_A_ACTA1502_0 (NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F)	4u9u	NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F (Vibrio cholerae)	5 / 5	ARG A 229 GLY A 282 ALA A 283 GLY A 379 PRO A 380	ACT A1502 ( 3.8A) ACT A1502 (-3.3A) FAD A1501 (-3.7A) ACT A1502 (-4.0A) ACT A1502 (-4.0A)	0.02A	4u9uA-4u9uA: 49.2	4u9uA-4u9uA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4U9U_B_ACTB1502_0 (NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F)	4u9u	NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F (Vibrio cholerae)	5 / 5	ARG A 229 GLY A 282 ALA A 283 GLY A 379 PRO A 380	ACT A1502 ( 3.8A) ACT A1502 (-3.3A) FAD A1501 (-3.7A) ACT A1502 (-4.0A) ACT A1502 (-4.0A)	0.20A	4u9uB-4u9uA: 46.4	4u9uB-4u9uA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FHZ_D_READ602_1 (ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3)	4u9u	NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F (Vibrio cholerae)	5 / 12	ILE A 223 ARG A 289 CYH A 135 CYH A 258 LEU A 226	None	1.36A	5fhzD-4u9uA: 5.4	5fhzD-4u9uA: 19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HWD_K_BO2K301_0 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4u9u	NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F (Vibrio cholerae)	5 / 11	ALA A 286 ALA A 215 GLY A 281 GLY A 282 ALA A 283	FAD A1501 ( 4.4A) None None ACT A1502 (-3.3A) FAD A1501 (-3.7A)	0.87A	6hwdK-4u9uA: undetectable 6hwdL-4u9uA: undetectable	6hwdK-4u9uA: 14.71 6hwdL-4u9uA: 17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HWD_Y_BO2Y301_0 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4u9u	NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F (Vibrio cholerae)	5 / 11	ALA A 286 ALA A 215 GLY A 281 GLY A 282 ALA A 283	FAD A1501 ( 4.4A) None None ACT A1502 (-3.3A) FAD A1501 (-3.7A)	0.87A	6hwdY-4u9uA: undetectable 6hwdZ-4u9uA: undetectable	6hwdY-4u9uA: 14.71 6hwdZ-4u9uA: 17.83

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2D55_C_DVAC8_0","ACTINOMYCIN D","4u9u","NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F","Vibrio cholerae",3,"PRO A 242;THR A 232;PRO A 234","FAD A1501 (-4.8A);None;None","0.44A","2d55C-4u9uA:undetectable","2d55C-4u9uA:2.68"],["3KPC_A_SAMA1000_0","UNCHARACTERIZED PROTEIN MJ0100","4u9u","NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F","Vibrio cholerae",5,"ILE A 279;VAL A 387;ILE A 388;ASN A 400;ILE A 401","None","1.26A","3kpcA-4u9uA:undetectable","3kpcA-4u9uA:18.44"],["3W1W_B_CHDB502_0","FERROCHELATASE, MITOCHONDRIAL","4u9u","NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F","Vibrio cholerae",5,"ILE A 388;LEU A 391;PRO A 287;SER A 213;GLY A 280","None;None;None;FAD A1501 (-3.1A);None","1.08A","3w1wB-4u9uA:3.3","3w1wB-4u9uA:22.19"],["4MMD_A_29EA603_1","TRANSPORTER","4u9u","NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F","Vibrio cholerae",5,"PRO A 161;GLY A 166;PHE A 162;SER A 261;GLY A 262","None","1.23A","4mmdA-4u9uA:undetectable","4mmdA-4u9uA:20.46"],["4U9U_A_ACTA1502_0","NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F","4u9u","NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F","Vibrio cholerae",5,"ARG A 229;GLY A 282;ALA A 283;GLY A 379;PRO A 380","ACT A1502 ( 3.8A);ACT A1502 (-3.3A);FAD A1501 (-3.7A);ACT A1502 (-4.0A);ACT A1502 (-4.0A)","0.02A","4u9uA-4u9uA:49.2","4u9uA-4u9uA:100.00"],["4U9U_B_ACTB1502_0","NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F","4u9u","NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F","Vibrio cholerae",5,"ARG A 229;GLY A 282;ALA A 283;GLY A 379;PRO A 380","ACT A1502 ( 3.8A);ACT A1502 (-3.3A);FAD A1501 (-3.7A);ACT A1502 (-4.0A);ACT A1502 (-4.0A)","0.20A","4u9uB-4u9uA:46.4","4u9uB-4u9uA:100.00"],["5FHZ_D_READ602_1","ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3","4u9u","NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F","Vibrio cholerae",5,"ILE A 223;ARG A 289;CYH A 135;CYH A 258;LEU A 226","None","1.36A","5fhzD-4u9uA:5.4","5fhzD-4u9uA:19.17"],["6HWD_K_BO2K301_0","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4u9u","NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F","Vibrio cholerae",5,"ALA A 286;ALA A 215;GLY A 281;GLY A 282;ALA A 283","FAD A1501 ( 4.4A);None;None;ACT A1502 (-3.3A);FAD A1501 (-3.7A)","0.87A","6hwdK-4u9uA:undetectable;6hwdL-4u9uA:undetectable","6hwdK-4u9uA:14.71;6hwdL-4u9uA:17.83"],["6HWD_Y_BO2Y301_0","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4u9u","NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F","Vibrio cholerae",5,"ALA A 286;ALA A 215;GLY A 281;GLY A 282;ALA A 283","FAD A1501 ( 4.4A);None;None;ACT A1502 (-3.3A);FAD A1501 (-3.7A)","0.87A","6hwdY-4u9uA:undetectable;6hwdZ-4u9uA:undetectable","6hwdY-4u9uA:14.71;6hwdZ-4u9uA:17.83"]]