SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u9v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 4u9v N-ALPHA-ACETYLTRANSF
ERASE 40
(Homo
sapiens) 		4 / 6 LEU B 173
LEU B 214
ILE B 156
ARG B 216
 ACO  B 301 ( 4.2A)
None
None
None
 1.01A 2rlfA-4u9vB:
undetectable
2rlfB-4u9vB:
undetectable		 2rlfA-4u9vB:
10.71
2rlfB-4u9vB:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 4u9v N-ALPHA-ACETYLTRANSF
ERASE 40
(Homo
sapiens) 		4 / 6 LEU B 173
LEU B 214
ILE B 156
ARG B 216
 ACO  B 301 ( 4.2A)
None
None
None
 0.90A 2rlfC-4u9vB:
undetectable
2rlfD-4u9vB:
undetectable		 2rlfC-4u9vB:
10.71
2rlfD-4u9vB:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 4u9v N-ALPHA-ACETYLTRANSF
ERASE 40
(Homo
sapiens) 		3 / 3 CYH B 137
HIS B 123
PHE B 124
 ACO  B 301 ( 4.3A)
None
None
 1.14A 3cr4X-4u9vB:
undetectable		 3cr4X-4u9vB:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4u9v N-ALPHA-ACETYLTRANSF
ERASE 40
(Homo
sapiens) 		3 / 3 ASP B 132
ARG B 217
LYS B 170
 None
 1.27A 3wipG-4u9vB:
undetectable		 3wipG-4u9vB:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 4u9v N-ALPHA-ACETYLTRANSF
ERASE 40
(Homo
sapiens) 		4 / 8 LYS B  46
ILE B  57
LEU B 109
ILE B 158
 None
 0.96A 4dtaB-4u9vB:
undetectable		 4dtaB-4u9vB:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4u9v N-ALPHA-ACETYLTRANSF
ERASE 40
(Homo
sapiens) 		4 / 7 LEU B 155
LYS B 153
GLN B 160
LEU B 161
 None
 1.12A 4ib4A-4u9vB:
undetectable		 4ib4A-4u9vB:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4u9v N-ALPHA-ACETYLTRANSF
ERASE 40
(Homo
sapiens) 		5 / 11 VAL B 140
ALA B 120
LEU B 190
TYR B  48
LEU B 109
 ACO  B 301 (-4.2A)
None
None
None
None
 1.04A 6dk1B-4u9vB:
undetectable		 6dk1B-4u9vB:
20.00