SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uad'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		5 / 11 LEU A 260
ALA A 272
LEU A 268
ALA A 230
THR A 227
 None
 1.26A 1tz8A-4uadA:
undetectable
1tz8B-4uadA:
undetectable		 1tz8A-4uadA:
14.71
1tz8B-4uadA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		4 / 6 ARG A 395
ALA A 441
THR A 403
ALA A 398
 None
 0.96A 1w0gA-4uadA:
undetectable		 1w0gA-4uadA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		5 / 12 LEU A 303
LEU A 315
ILE A 360
LEU A 345
LEU A 342
 None
 1.04A 2bdmA-4uadA:
undetectable		 2bdmA-4uadA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		5 / 12 LEU A 206
GLY A 192
ASN A 236
ALA A 233
ALA A 230
 None
 1.10A 2bm9C-4uadA:
undetectable		 2bm9C-4uadA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		5 / 11 LEU A 299
LEU A 261
SER A 266
LEU A 269
LEU A 302
 None
 1.04A 2ceoA-4uadA:
undetectable		 2ceoA-4uadA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		5 / 10 LEU A 420
GLY A 421
LEU A 417
ILE A 402
PHE A 380
 None
 1.08A 2f8dA-4uadA:
undetectable		 2f8dA-4uadA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		5 / 10 LEU A 420
GLY A 421
LEU A 417
ILE A 402
PHE A 380
 None
 1.10A 2f8dB-4uadA:
undetectable		 2f8dB-4uadA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		3 / 3 SER A 347
HIS A 305
ASP A 267
 None
 0.76A 2oxtA-4uadA:
undetectable		 2oxtA-4uadA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		5 / 12 THR A 410
ILE A 414
GLY A 409
PHE A 380
ILE A 375
 None
 1.29A 2y7kC-4uadA:
undetectable		 2y7kC-4uadA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		5 / 9 THR A 410
ILE A 414
GLY A 409
PHE A 380
ILE A 375
 None
 1.26A 2y7wA-4uadA:
undetectable		 2y7wA-4uadA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		5 / 7 THR A 410
ILE A 414
GLY A 409
PHE A 380
ILE A 375
 None
 1.26A 2y7wC-4uadA:
undetectable		 2y7wC-4uadA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		5 / 9 ILE A 470
ILE A 479
LEU A 497
GLU A 446
LEU A 449
 None
 1.31A 3f78A-4uadA:
undetectable		 3f78A-4uadA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		5 / 9 ILE A 470
ILE A 479
LEU A 497
GLU A 446
LEU A 449
 None
 1.35A 3f78B-4uadA:
undetectable		 3f78B-4uadA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		5 / 12 LEU A 476
LEU A 442
LEU A 445
LEU A 449
LEU A 482
 None
 1.00A 3hm1A-4uadA:
undetectable		 3hm1A-4uadA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		5 / 12 ALA A 275
LEU A 260
LEU A 257
SER A 280
ALA A 230
 None
 1.45A 3lbdA-4uadA:
undetectable		 3lbdA-4uadA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		4 / 5 LEU A 269
LEU A 268
LEU A 257
SER A 258
 None
 0.99A 3vhuA-4uadA:
undetectable		 3vhuA-4uadA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		5 / 12 ILE A 470
LEU A 476
ALA A 494
LEU A 497
LEU A 445
 None
 1.38A 4m11C-4uadA:
undetectable		 4m11C-4uadA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		5 / 12 GLY A 324
ASN A 284
ILE A 363
ASN A 320
THR A 359
 None
 1.35A 4pooA-4uadA:
undetectable		 4pooA-4uadA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		4 / 5 TYR A 501
ILE A 479
PRO A 465
THR A 406
 None
 1.15A 4ze1A-4uadA:
undetectable		 4ze1A-4uadA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		3 / 3 ALA A 233
ASN A 236
LEU A 237
 None
 0.39A 5i1nB-4uadA:
undetectable		 5i1nB-4uadA:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		3 / 3 ALA A 233
ASN A 236
LEU A 237
 None
 0.40A 5i1oC-4uadA:
undetectable		 5i1oC-4uadA:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		3 / 3 ALA A 233
ASN A 236
LEU A 237
 None
 0.35A 5i1pA-4uadA:
undetectable		 5i1pA-4uadA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		4 / 6 TYR A 501
ASP A 477
LEU A 476
GLY A 475
 None
 0.98A 5nooC-4uadA:
undetectable		 5nooC-4uadA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		4 / 6 ASP A 182
GLN A 184
LEU A 217
SER A 221
 None
 0.84A 6ekuA-4uadA:
undetectable		 6ekuA-4uadA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens) 		4 / 6 ARG A 395
ALA A 441
THR A 403
ALA A 398
 None
 0.97A 6ma6A-4uadA:
undetectable		 6ma6A-4uadA:
10.62