SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uap'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JC9_A_ADNA1497_1 (CYTOSOLIC PURINE 5'-NUCLEOTIDASE)	4uap	GLYCOSYL HYDROLASE, FAMILY 31/FIBRONECTIN TYPE III DOMAIN PROTEIN (Clostridium perfringens)	4 / 7	ARG A 76 ASP A 39 THR A 140 ILE A 85	NGA A 201 (-2.7A) None NGA A 201 ( 4.6A) None	1.15A	2jc9A-4uapA: undetectable	2jc9A-4uapA: 14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RFM_A_CFFA330_1 (ADENOSINE RECEPTOR A2A)	4uap	GLYCOSYL HYDROLASE, FAMILY 31/FIBRONECTIN TYPE III DOMAIN PROTEIN (Clostridium perfringens)	4 / 7	VAL A 91 LEU A 141 MET A 38 ILE A 143	None	0.88A	3rfmA-4uapA: undetectable	3rfmA-4uapA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HGC_A_HCYA501_1 (SERPIN)	4uap	GLYCOSYL HYDROLASE, FAMILY 31/FIBRONECTIN TYPE III DOMAIN PROTEIN (Clostridium perfringens)	5 / 12	VAL A 116 PHE A 62 ILE A 127 PHE A 148 ASN A 70	None	1.39A	5hgcA-4uapA: undetectable	5hgcA-4uapA: 17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HU9_Q_PCFQ202_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 5A, MITOCHONDRIAL CYTOCHROME C OXIDASE SUBUNIT 1)	4uap	GLYCOSYL HYDROLASE, FAMILY 31/FIBRONECTIN TYPE III DOMAIN PROTEIN (Clostridium perfringens)	4 / 6	TYR A 117 ILE A 73 ALA A 131 ASP A 103	None	1.14A	6hu9m-4uapA: undetectable 6hu9q-4uapA: undetectable	6hu9m-4uapA: 15.48 6hu9q-4uapA: 26.22

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2JC9_A_ADNA1497_1","CYTOSOLIC PURINE 5'-NUCLEOTIDASE","4uap","GLYCOSYL HYDROLASE, FAMILY 31\/FIBRONECTIN TYPE III DOMAIN PROTEIN","Clostridium perfringens",4,"ARG A  76;ASP A  39;THR A 140;ILE A  85","NGA A 201 (-2.7A);None;NGA A 201 ( 4.6A);None","1.15A","2jc9A-4uapA:undetectable","2jc9A-4uapA:14.03"],["3RFM_A_CFFA330_1","ADENOSINE RECEPTOR A2A","4uap","GLYCOSYL HYDROLASE, FAMILY 31\/FIBRONECTIN TYPE III DOMAIN PROTEIN","Clostridium perfringens",4,"VAL A  91;LEU A 141;MET A  38;ILE A 143","None","0.88A","3rfmA-4uapA:undetectable","3rfmA-4uapA:20.00"],["5HGC_A_HCYA501_1","SERPIN","4uap","GLYCOSYL HYDROLASE, FAMILY 31\/FIBRONECTIN TYPE III DOMAIN PROTEIN","Clostridium perfringens",5,"VAL A 116;PHE A  62;ILE A 127;PHE A 148;ASN A  70","None","1.39A","5hgcA-4uapA:undetectable","5hgcA-4uapA:17.40"],["6HU9_Q_PCFQ202_0","CYTOCHROME C OXIDASE POLYPEPTIDE 5A, MITOCHONDRIAL;CYTOCHROME C OXIDASE SUBUNIT 1","4uap","GLYCOSYL HYDROLASE, FAMILY 31\/FIBRONECTIN TYPE III DOMAIN PROTEIN","Clostridium perfringens",4,"TYR A 117;ILE A  73;ALA A 131;ASP A 103","None","1.14A","6hu9m-4uapA:undetectable;6hu9q-4uapA:undetectable","6hu9m-4uapA:15.48;6hu9q-4uapA:26.22"]]