SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uaq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2
(Mycobacterium
tuberculosis) 		4 / 7 THR A 137
SER A 185
TYR A 183
TRP A 149
 None
 1.36A 1eiiA-4uaqA:
undetectable		 1eiiA-4uaqA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 164
GLY A 162
SER A 168
GLU A 172
 None
 0.66A 1mrjA-4uaqA:
undetectable		 1mrjA-4uaqA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2
(Mycobacterium
tuberculosis) 		3 / 3 ASP A  70
LEU A  59
LEU A  60
 None
 0.73A 1np1B-4uaqA:
undetectable		 1np1B-4uaqA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2
(Mycobacterium
tuberculosis) 		3 / 3 SER A  31
ASP A 105
CYH A 381
 None
 1.12A 2br4E-4uaqA:
2.2		 2br4E-4uaqA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  76
ALA A  78
LEU A  95
ALA A  98
VAL A  35
 None
 1.00A 2bxgB-4uaqA:
undetectable		 2bxgB-4uaqA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 441
SER A 554
LEU A 522
GLY A 524
 None
 1.04A 2j2pD-4uaqA:
undetectable
2j2pF-4uaqA:
undetectable		 2j2pD-4uaqA:
13.71
2j2pF-4uaqA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 102
LEU A  99
LEU A  95
GLY A 125
LEU A  62
 None
 0.85A 2ouzA-4uaqA:
undetectable		 2ouzA-4uaqA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)		 4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 545
PRO A 407
GLY A 385
MET A 109
 None
 1.31A 3aqiB-4uaqA:
undetectable		 3aqiB-4uaqA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2
(Mycobacterium
tuberculosis) 		4 / 5 ALA A 372
LEU A 230
GLY A 190
THR A 182
 None
 0.97A 3dl9A-4uaqA:
undetectable		 3dl9A-4uaqA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 127
VAL A 212
ILE A 121
VAL A 135
VAL A 133
 None
 1.06A 3nu9B-4uaqA:
undetectable		 3nu9B-4uaqA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2
(Mycobacterium
tuberculosis) 		4 / 4 PRO A 444
LEU A 525
ILE A 506
ARG A 545
 None
 1.42A 3w1wA-4uaqA:
undetectable		 3w1wA-4uaqA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 224
ASP A 219
ASN A 540
 None
 0.80A 4q5mA-4uaqA:
undetectable		 4q5mA-4uaqA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2
(Mycobacterium
tuberculosis) 		5 / 10 GLU A 414
LEU A 458
HIS A 434
THR A 494
LEU A 525
 None
 1.36A 5mm4B-4uaqA:
undetectable		 5mm4B-4uaqA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2
(Mycobacterium
tuberculosis) 		5 / 10 GLU A 414
LEU A 462
HIS A 434
THR A 494
LEU A 525
 None
 1.45A 5mm4B-4uaqA:
undetectable		 5mm4B-4uaqA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2
(Mycobacterium
tuberculosis) 		6 / 12 LEU A 525
GLY A 553
LEU A 522
GLY A 523
GLY A 524
PRO A 444
 None
 1.42A 5wyqB-4uaqA:
undetectable		 5wyqB-4uaqA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 594
ASP A 595
GLN A 598
VAL A 432
 None
 1.27A 6bzoF-4uaqA:
undetectable		 6bzoF-4uaqA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 215
VAL A 106
ALA A 387
THR A 386
 None
 0.97A 6cduC-4uaqA:
undetectable
6cduD-4uaqA:
3.5		 6cduC-4uaqA:
16.58
6cduD-4uaqA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 127
VAL A 212
ILE A 121
VAL A 135
VAL A 133
 None
 1.07A 6dh0B-4uaqA:
undetectable		 6dh0B-4uaqA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2
(Mycobacterium
tuberculosis) 		5 / 12 GLN A 347
GLY A 362
GLY A 234
GLU A 363
THR A 361
 None
 1.21A 6exiC-4uaqA:
undetectable
6exiD-4uaqA:
undetectable		 6exiC-4uaqA:
8.42
6exiD-4uaqA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2
(Mycobacterium
tuberculosis) 		4 / 5 GLY A 190
LEU A 373
SER A 207
TYR A 177
 None
 1.22A 6ji6A-4uaqA:
undetectable		 6ji6A-4uaqA:
14.14