SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uar'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4uar PROTEIN CBBY
(Rhodobacter
sphaeroides) 		4 / 4 LEU A 210
VAL A 193
CYH A 191
ALA A 184
 None
 1.29A 1mz9E-4uarA:
undetectable		 1mz9E-4uarA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4uar PROTEIN CBBY
(Rhodobacter
sphaeroides) 		4 / 8 PHE A 214
ASP A 224
LEU A 223
GLY A 222
 None
 0.80A 1rtsA-4uarA:
undetectable		 1rtsA-4uarA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 4uar PROTEIN CBBY
(Rhodobacter
sphaeroides) 		4 / 6 PHE A 138
ALA A 112
LEU A 111
ILE A   5
 None
 1.06A 1sbrA-4uarA:
undetectable
1sbrB-4uarA:
undetectable		 1sbrA-4uarA:
20.43
1sbrB-4uarA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 4uar PROTEIN CBBY
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 220
ASP A  99
GLY A  96
PHE A 214
ALA A 102
 None
 1.21A 2kceB-4uarA:
undetectable		 2kceB-4uarA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 4uar PROTEIN CBBY
(Rhodobacter
sphaeroides) 		4 / 6 ILE A 109
ARG A 110
LEU A 111
ASP A 139
 None
 0.83A 2rlfA-4uarA:
undetectable
2rlfD-4uarA:
undetectable		 2rlfA-4uarA:
12.94
2rlfD-4uarA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 4uar PROTEIN CBBY
(Rhodobacter
sphaeroides) 		4 / 5 ASP A 139
ILE A 109
VAL A 172
THR A  12
 None
 1.11A 3eigA-4uarA:
2.8		 3eigA-4uarA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4uar PROTEIN CBBY
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 219
ALA A 215
GLY A  96
LEU A 174
ILE A 192
 None
 0.92A 3ku1A-4uarA:
undetectable		 3ku1A-4uarA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4uar PROTEIN CBBY
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 219
ALA A 215
GLY A  96
LEU A 174
ILE A 192
 None
 0.91A 3ku1C-4uarA:
undetectable		 3ku1C-4uarA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 4uar PROTEIN CBBY
(Rhodobacter
sphaeroides) 		4 / 5 ASN A 121
ASP A   8
GLU A 202
SER A 118
 None
 1.49A 3p2kC-4uarA:
2.0		 3p2kC-4uarA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 4uar PROTEIN CBBY
(Rhodobacter
sphaeroides) 		3 / 3 LYS A 185
LEU A 181
ALA A 184
 None
 0.79A 4iizA-4uarA:
undetectable		 4iizA-4uarA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 4uar PROTEIN CBBY
(Rhodobacter
sphaeroides) 		5 / 9 ILE A   5
LEU A 174
ILE A 109
PHE A 214
GLY A 219
 None
 1.11A 4kukA-4uarA:
undetectable		 4kukA-4uarA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4uar PROTEIN CBBY
(Rhodobacter
sphaeroides) 		5 / 12 PHE A   7
GLU A 175
ALA A 171
ALA A 187
GLY A 188
 None
 1.08A 4oaeA-4uarA:
undetectable		 4oaeA-4uarA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4uar PROTEIN CBBY
(Rhodobacter
sphaeroides) 		4 / 6 ARG A 182
GLY A 180
SER A 177
LEU A 178
 None
 1.25A 5bphA-4uarA:
2.8		 5bphA-4uarA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 4uar PROTEIN CBBY
(Rhodobacter
sphaeroides) 		4 / 6 SER A 177
GLU A 202
ASP A 155
GLY A 186
 None
 0.96A 5cdpA-4uarA:
undetectable
5cdpB-4uarA:
2.2		 5cdpA-4uarA:
21.17
5cdpB-4uarA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 4uar PROTEIN CBBY
(Rhodobacter
sphaeroides) 		4 / 7 PHE A 214
ASP A 224
LEU A 223
GLY A 222
 None
 0.82A 5h3aB-4uarA:
undetectable		 5h3aB-4uarA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 4uar PROTEIN CBBY
(Rhodobacter
sphaeroides) 		5 / 12 HIS A  75
GLY A  11
THR A  49
GLY A  50
GLY A  51
 None
None
None
GOL  A 301 (-3.4A)
GOL  A 301 ( 4.7A)
 1.10A 6brdB-4uarA:
undetectable		 6brdB-4uarA:
19.47