SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uav'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S9P_A_DESA459_1 (ESTROGEN-RELATED RECEPTOR GAMMA)	4uav	HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN AT3G48420 (Arabidopsis thaliana)	5 / 12	LEU A 212 LEU A 213 ALA A 218 VAL A 194 ILE A 169	None	1.00A	1s9pA-4uavA: undetectable	1s9pA-4uavA: 19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S9P_D_DESD600_1 (ESTROGEN-RELATED RECEPTOR GAMMA)	4uav	HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN AT3G48420 (Arabidopsis thaliana)	5 / 12	LEU A 212 LEU A 213 ALA A 218 VAL A 194 ILE A 169	None	1.12A	1s9pD-4uavA: undetectable	1s9pD-4uavA: 19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SKX_A_RFPA1_2 (ORPHAN NUCLEAR RECEPTOR PXR)	4uav	HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN AT3G48420 (Arabidopsis thaliana)	4 / 5	LYS A 252 PHE A 304 LEU A 313 LEU A 188	None	1.28A	1skxA-4uavA: undetectable	1skxA-4uavA: 21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J2P_F_SC2F1291_1 (FICOLIN-2)	4uav	HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN AT3G48420 (Arabidopsis thaliana)	4 / 6	LEU A 263 ASP A 258 ASP A 82 GLU A 284	None MG A 401 (-2.6A) MG A 401 (-2.7A) None	1.23A	2j2pE-4uavA: undetectable 2j2pF-4uavA: undetectable	2j2pE-4uavA: 20.90 2j2pF-4uavA: 20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KVV_A_URFA254_1 (URIDINE PHOSPHORYLASE)	4uav	HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN AT3G48420 (Arabidopsis thaliana)	4 / 6	GLY A 156 GLN A 160 ARG A 106 ILE A 154	None	1.14A	3kvvA-4uavA: 2.9	3kvvA-4uavA: 23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KVV_E_URFE254_1 (URIDINE PHOSPHORYLASE)	4uav	HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN AT3G48420 (Arabidopsis thaliana)	4 / 6	GLY A 156 GLN A 160 ARG A 106 ILE A 154	None	1.17A	3kvvE-4uavA: 2.8	3kvvE-4uavA: 23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SP9_B_IL2B901_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR DELTA)	4uav	HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN AT3G48420 (Arabidopsis thaliana)	5 / 12	LEU A 87 VAL A 196 PHE A 224 LEU A 188 VAL A 184	None	1.14A	3sp9B-4uavA: undetectable	3sp9B-4uavA: 21.03

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1S9P_A_DESA459_1","ESTROGEN-RELATED RECEPTOR GAMMA","4uav","HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN AT3G48420","Arabidopsis thaliana",5,"LEU A 212;LEU A 213;ALA A 218;VAL A 194;ILE A 169","None","1.00A","1s9pA-4uavA:undetectable","1s9pA-4uavA:19.22"],["1S9P_D_DESD600_1","ESTROGEN-RELATED RECEPTOR GAMMA","4uav","HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN AT3G48420","Arabidopsis thaliana",5,"LEU A 212;LEU A 213;ALA A 218;VAL A 194;ILE A 169","None","1.12A","1s9pD-4uavA:undetectable","1s9pD-4uavA:19.22"],["1SKX_A_RFPA1_2","ORPHAN NUCLEAR RECEPTOR PXR","4uav","HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN AT3G48420","Arabidopsis thaliana",4,"LYS A 252;PHE A 304;LEU A 313;LEU A 188","None","1.28A","1skxA-4uavA:undetectable","1skxA-4uavA:21.41"],["2J2P_F_SC2F1291_1","FICOLIN-2;FICOLIN-2","4uav","HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN AT3G48420","Arabidopsis thaliana",4,"LEU A 263;ASP A 258;ASP A  82;GLU A 284","None; MG A 401 (-2.6A); MG A 401 (-2.7A);None","1.23A","2j2pE-4uavA:undetectable;2j2pF-4uavA:undetectable","2j2pE-4uavA:20.90;2j2pF-4uavA:20.90"],["3KVV_A_URFA254_1","URIDINE PHOSPHORYLASE","4uav","HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN AT3G48420","Arabidopsis thaliana",4,"GLY A 156;GLN A 160;ARG A 106;ILE A 154","None","1.14A","3kvvA-4uavA:2.9","3kvvA-4uavA:23.84"],["3KVV_E_URFE254_1","URIDINE PHOSPHORYLASE","4uav","HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN AT3G48420","Arabidopsis thaliana",4,"GLY A 156;GLN A 160;ARG A 106;ILE A 154","None","1.17A","3kvvE-4uavA:2.8","3kvvE-4uavA:23.84"],["3SP9_B_IL2B901_1","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA","4uav","HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN AT3G48420","Arabidopsis thaliana",5,"LEU A  87;VAL A 196;PHE A 224;LEU A 188;VAL A 184","None","1.14A","3sp9B-4uavA:undetectable","3sp9B-4uavA:21.03"]]