SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uc0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		5 / 10 ALA A 212
PHE A 215
GLY A 216
GLU A 208
PRO A 207
 None
 1.27A 1cmcA-4uc0A:
undetectable
1cmcB-4uc0A:
undetectable		 1cmcA-4uc0A:
14.09
1cmcB-4uc0A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		5 / 11 GLU A 208
PRO A 207
ALA A 212
PHE A 215
GLY A 216
 None
 1.36A 1mjqA-4uc0A:
undetectable
1mjqB-4uc0A:
undetectable		 1mjqA-4uc0A:
14.09
1mjqB-4uc0A:
14.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		6 / 10 GLY A 110
GLU A 185
VAL A 201
GLY A 202
THR A 226
ASN A 227
 HPA  A 301 (-3.5A)
HPA  A 301 (-2.9A)
HPA  A 301 (-4.9A)
HPA  A 301 (-3.6A)
HPA  A 301 (-4.2A)
HPA  A 301 (-3.0A)
 0.62A 1pwyE-4uc0A:
32.6		 1pwyE-4uc0A:
40.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		7 / 10 GLY A 110
PHE A 184
GLU A 185
GLY A 202
MET A 203
THR A 226
ASN A 227
 HPA  A 301 (-3.5A)
None
HPA  A 301 (-2.9A)
HPA  A 301 (-3.6A)
HPA  A 301 (-4.4A)
HPA  A 301 (-4.2A)
HPA  A 301 (-3.0A)
 0.60A 1pwyE-4uc0A:
32.6		 1pwyE-4uc0A:
40.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		5 / 10 GLY A 202
PHE A 184
GLU A 185
GLY A 181
VAL A 201
 HPA  A 301 (-3.6A)
None
HPA  A 301 (-2.9A)
None
HPA  A 301 (-4.9A)
 1.25A 1pwyE-4uc0A:
32.6		 1pwyE-4uc0A:
40.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		8 / 10 GLY A 110
PHE A 184
GLU A 185
VAL A 201
GLY A 202
MET A 203
THR A 226
ASN A 227
 HPA  A 301 (-3.5A)
None
HPA  A 301 (-2.9A)
HPA  A 301 (-4.9A)
HPA  A 301 (-3.6A)
HPA  A 301 (-4.4A)
HPA  A 301 (-4.2A)
HPA  A 301 (-3.0A)
 0.54A 1v3qE-4uc0A:
32.9		 1v3qE-4uc0A:
40.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		4 / 7 VAL A 254
LYS A 258
ILE A 261
GLY A 264
 None
 0.87A 3bjwB-4uc0A:
undetectable		 3bjwB-4uc0A:
15.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		5 / 6 GLY A 110
GLU A 185
GLY A 202
MET A 203
ASN A 227
 HPA  A 301 (-3.5A)
HPA  A 301 (-2.9A)
HPA  A 301 (-3.6A)
HPA  A 301 (-4.4A)
HPA  A 301 (-3.0A)
 0.61A 3e9rA-4uc0A:
33.0		 3e9rA-4uc0A:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		5 / 6 GLY A 110
GLU A 185
GLY A 202
MET A 203
ASN A 227
 HPA  A 301 (-3.5A)
HPA  A 301 (-2.9A)
HPA  A 301 (-3.6A)
HPA  A 301 (-4.4A)
HPA  A 301 (-3.0A)
 0.63A 3e9rC-4uc0A:
32.8		 3e9rC-4uc0A:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		8 / 12 SER A  25
ALA A 108
GLY A 110
GLU A 185
VAL A 201
GLY A 202
MET A 203
ASN A 227
 None
HPA  A 301 (-4.0A)
HPA  A 301 (-3.5A)
HPA  A 301 (-2.9A)
HPA  A 301 (-4.9A)
HPA  A 301 (-3.6A)
HPA  A 301 (-4.4A)
HPA  A 301 (-3.0A)
 0.61A 3f8wA-4uc0A:
33.4		 3f8wA-4uc0A:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		8 / 12 TYR A  80
ALA A 108
GLY A 110
GLU A 185
VAL A 201
GLY A 202
MET A 203
ASN A 227
 None
HPA  A 301 (-4.0A)
HPA  A 301 (-3.5A)
HPA  A 301 (-2.9A)
HPA  A 301 (-4.9A)
HPA  A 301 (-3.6A)
HPA  A 301 (-4.4A)
HPA  A 301 (-3.0A)
 0.43A 3f8wA-4uc0A:
33.4		 3f8wA-4uc0A:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		8 / 12 HIS A  78
TYR A  80
GLY A 110
GLU A 185
VAL A 201
GLY A 202
MET A 203
ASN A 227
 None
None
HPA  A 301 (-3.5A)
HPA  A 301 (-2.9A)
HPA  A 301 (-4.9A)
HPA  A 301 (-3.6A)
HPA  A 301 (-4.4A)
HPA  A 301 (-3.0A)
 0.43A 3f8wB-4uc0A:
33.3		 3f8wB-4uc0A:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		8 / 12 SER A  25
HIS A  78
GLY A 110
GLU A 185
VAL A 201
GLY A 202
MET A 203
ASN A 227
 None
None
HPA  A 301 (-3.5A)
HPA  A 301 (-2.9A)
HPA  A 301 (-4.9A)
HPA  A 301 (-3.6A)
HPA  A 301 (-4.4A)
HPA  A 301 (-3.0A)
 0.62A 3f8wB-4uc0A:
33.3		 3f8wB-4uc0A:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		9 / 12 HIS A  78
TYR A  80
ALA A 108
GLY A 110
GLU A 185
VAL A 201
GLY A 202
MET A 203
ASN A 227
 None
None
HPA  A 301 (-4.0A)
HPA  A 301 (-3.5A)
HPA  A 301 (-2.9A)
HPA  A 301 (-4.9A)
HPA  A 301 (-3.6A)
HPA  A 301 (-4.4A)
HPA  A 301 (-3.0A)
 0.40A 3f8wC-4uc0A:
33.5		 3f8wC-4uc0A:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		9 / 12 SER A  25
HIS A  78
ALA A 108
GLY A 110
GLU A 185
VAL A 201
GLY A 202
MET A 203
ASN A 227
 None
None
HPA  A 301 (-4.0A)
HPA  A 301 (-3.5A)
HPA  A 301 (-2.9A)
HPA  A 301 (-4.9A)
HPA  A 301 (-3.6A)
HPA  A 301 (-4.4A)
HPA  A 301 (-3.0A)
 0.61A 3f8wC-4uc0A:
33.5		 3f8wC-4uc0A:
35.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		5 / 10 ILE A 261
PHE A  65
ILE A  70
ILE A 104
LEU A  30
 None
 1.01A 3o1cA-4uc0A:
undetectable		 3o1cA-4uc0A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		5 / 10 ILE A 261
PHE A  65
ILE A  70
ILE A 104
LEU A  30
 None
 1.01A 3o1xA-4uc0A:
undetectable		 3o1xA-4uc0A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		5 / 10 ILE A 261
PHE A  65
ILE A  70
ILE A 104
LEU A  30
 None
 1.04A 3qgzA-4uc0A:
undetectable		 3qgzA-4uc0A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		4 / 6 THR A 205
ASN A 107
GLY A  24
ILE A  21
 None
 1.04A 3w9tF-4uc0A:
undetectable		 3w9tF-4uc0A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		4 / 6 THR A 195
GLY A 197
ILE A 128
LEU A 112
 None
 1.21A 4ac9C-4uc0A:
4.8		 4ac9C-4uc0A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		4 / 6 THR A 195
GLY A 197
ILE A 128
LEU A 112
 None
 1.19A 4acaC-4uc0A:
undetectable		 4acaC-4uc0A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		6 / 12 ILE A 104
THR A 106
LEU A  27
LEU A  30
GLY A  28
ILE A  70
 None
 1.38A 4c9lA-4uc0A:
undetectable		 4c9lA-4uc0A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		6 / 12 ILE A 104
THR A 106
LEU A  27
LEU A  30
GLY A  28
ILE A  70
 None
 1.35A 4c9lB-4uc0A:
undetectable		 4c9lB-4uc0A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		5 / 10 LEU A 253
LEU A 257
VAL A  22
LEU A 103
VAL A 100
 None
 1.14A 4po0A-4uc0A:
undetectable		 4po0A-4uc0A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Agrobacterium
vitis) 		4 / 7 ILE A 169
VAL A 121
ALA A 222
THR A 106
 None
 0.95A 6cduC-4uc0A:
undetectable
6cduD-4uc0A:
undetectable		 6cduC-4uc0A:
21.47
6cduD-4uc0A:
21.47