SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uc7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4uc7 NUCLEOPROTEIN
(Human
orthopneumovirus) 		5 / 12 LEU A 119
ILE A  44
PHE A 213
VAL A 212
PHE A 219
 None
 1.03A 2ygpA-4uc7A:
undetectable		 2ygpA-4uc7A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 4uc7 NUCLEOPROTEIN
(Human
orthopneumovirus) 		4 / 4 PHE A 111
LYS A 110
ILE A 104
THR A 121
 None
 1.44A 3ia4B-4uc7A:
undetectable		 3ia4B-4uc7A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 4uc7 NUCLEOPROTEIN
(Human
orthopneumovirus) 		4 / 4 PHE A 111
LYS A 110
ILE A 129
THR A 121
 None
 1.06A 3ia4B-4uc7A:
undetectable		 3ia4B-4uc7A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4uc7 NUCLEOPROTEIN
(Human
orthopneumovirus) 		4 / 6 VAL A  95
VAL A  40
ILE A  44
LEU A  64
 None
 0.90A 4l1wB-4uc7A:
undetectable		 4l1wB-4uc7A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 4uc7 NUCLEOPROTEIN
(Human
orthopneumovirus) 		5 / 12 LEU A 161
PHE A 243
ARG A 238
LEU A 164
ALA A 165
 None
 1.17A 5h5fA-4uc7A:
undetectable		 5h5fA-4uc7A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4uc7 NUCLEOPROTEIN
(Human
orthopneumovirus) 		4 / 5 PHE A 213
LEU A 161
GLY A 227
ILE A 220
 None
 1.02A 5ik1A-4uc7A:
undetectable		 5ik1A-4uc7A:
20.94