SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ucl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2B9E_A_SAMA1201_0 (NOL1/NOP2/SUN DOMAIN FAMILY, MEMBER 5 ISOFORM 2)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	5 / 12	GLY A1700 ASN A1701 LEU A1720 ASP A1755 PHE A1782	None	0.97A	2b9eA-4uclA: 7.7	2b9eA-4uclA: 20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BR4_F_SAMF301_0 (CEPHALOSPORIN HYDROXYLASE CMCI)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	5 / 12	GLU A1697 SER A1668 ASP A1755 ASP A1779 ALA A1780	None	1.05A	2br4F-4uclA: 9.6	2br4F-4uclA: 18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FK8_A_SAMA302_0 (METHOXY MYCOLIC ACID SYNTHASE 4)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	5 / 12	ILE A1695 GLY A1696 GLY A1698 LEU A1720 ALA A1780	None	0.67A	2fk8A-4uclA: 7.2	2fk8A-4uclA: 25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NYU_A_SAMA201_0 (PUTATIVE RIBOSOMAL RNA METHYLTRANSFERASE 2)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	5 / 12	GLY A1696 GLY A1700 TRP A1702 LEU A1720 LYS A1817	None	0.95A	2nyuA-4uclA: 10.2	2nyuA-4uclA: 16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NYU_B_SAMB201_0 (PUTATIVE RIBOSOMAL RNA METHYLTRANSFERASE 2)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	6 / 12	GLY A1696 GLY A1700 TRP A1702 LEU A1720 THR A1757 LYS A1817	None	1.03A	2nyuB-4uclA: 9.9	2nyuB-4uclA: 16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OK6_H_BEZH2001_0 (AROMATIC AMINE DEHYDROGENASE, LARGE SUBUNIT AROMATIC AMINE DEHYDROGENASE, SMALL SUBUNIT)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	5 / 10	PHE A1968 GLY A1998 LEU A2001 ASN A1661 PHE A1880	None	1.47A	2ok6A-4uclA: undetectable 2ok6H-4uclA: undetectable	2ok6A-4uclA: 22.27 2ok6H-4uclA: 15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OXT_C_SAMC300_0 (NUCLEOSIDE-2'-O-METH YLTRANSFERASE)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	5 / 12	GLY A1696 GLY A1698 LEU A1720 ASP A1779 LYS A1817	None	0.96A	2oxtC-4uclA: 11.0	2oxtC-4uclA: 21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WA2_B_SAMB1267_0 (NON-STRUCTURAL PROTEIN 5)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	5 / 12	GLY A1696 GLY A1698 LEU A1720 THR A1757 ASP A1779	None	0.96A	2wa2B-4uclA: 10.5	2wa2B-4uclA: 21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DOU_A_SAMA1_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	5 / 12	GLY A1696 GLY A1700 LEU A1720 ALA A1780 LYS A1817	None	0.50A	3douA-4uclA: 9.4	3douA-4uclA: 20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IHT_A_SAMA200_0 (S-ADENOSYL-L-METHION INE METHYL TRANSFERASE)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	5 / 12	GLY A1696 GLY A1698 GLY A1700 ASP A1755 ASP A1779	None	0.73A	3ihtA-4uclA: 7.6	3ihtA-4uclA: 19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L8L_B_DVAB6_0 (GRAMICIDIN D)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	3 / 3	TRP A1795 ALA A1756 VAL A1792	None	0.96A	3l8lA-4uclA: undetectable 3l8lB-4uclA: undetectable	3l8lA-4uclA: 28.00 3l8lB-4uclA: 3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OKX_B_SAMB201_0 (YAEB-LIKE PROTEIN RPA0152)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	3 / 3	LYS A1991 ARG A1662 LYS A1871	SO4 A2409 (-3.1A) SO4 A2409 (-3.1A) None	1.33A	3okxA-4uclA: undetectable	3okxA-4uclA: 17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QPK_A_CUA601_0 (LACCASE-1)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	4 / 5	HIS A1798 CYH A1805 ILE A1804 LEU A1773	ZN A2408 (-3.3A) ZN A2408 (-2.3A) ZN A2408 ( 4.5A) None	1.34A	3qpkA-4uclA: undetectable	3qpkA-4uclA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3R24_A_SAMA302_0 (2'-O-METHYL TRANSFERASE)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	5 / 12	GLY A1696 LEU A1720 ASP A1755 PHE A1782 LYS A1817	None	1.29A	3r24A-4uclA: 10.0	3r24A-4uclA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S3V_A_TOPA193_1 (DIHYDROFOLATE REDUCTASE)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	4 / 5	LEU A1814 ILE A1793 PRO A1828 PHE A1789	None	1.12A	3s3vA-4uclA: undetectable	3s3vA-4uclA: 20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3S_E_9PLE1_1 (CYTOCHROME P450 2A13)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	4 / 8	ALA A1704 ASN A1701 PHE A1667 ALA A1699	None	1.12A	3t3sE-4uclA: undetectable	3t3sE-4uclA: 21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KRH_A_SAMA900_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE 2)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	5 / 12	GLY A1696 GLY A1698 LEU A1720 ASP A1755 ALA A1756	None	0.63A	4krhA-4uclA: 7.6	4krhA-4uclA: 23.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UCI_A_ADNA2414_1 (RNA-DIRECTED RNA POLYMERASE L)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	5 / 6	GLU A1781 PHE A1782 PHE A1788 TYR A1818 HIS A1819	None	0.51A	4uciA-4uclA: 58.4	4uciA-4uclA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UCI_A_SAMA2409_0 (RNA-DIRECTED RNA POLYMERASE L)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	10 / 12	GLY A1696 GLU A1697 GLY A1698 GLY A1700 ASN A1701 TRP A1702 LEU A1720 ALA A1756 ALA A1780 LYS A1817	None	0.94A	4uciA-4uclA: 58.4	4uciA-4uclA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UCI_A_SAMA2409_0 (RNA-DIRECTED RNA POLYMERASE L)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	9 / 12	GLY A1696 GLU A1697 GLY A1698 GLY A1700 ASN A1701 TRP A1702 SER A1719 LEU A1720 ALA A1756	None	1.16A	4uciA-4uclA: 58.4	4uciA-4uclA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UCI_A_SAMA2409_0 (RNA-DIRECTED RNA POLYMERASE L)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	10 / 12	THR A1670 GLY A1696 GLY A1698 GLY A1700 ASN A1701 TRP A1702 LEU A1720 ALA A1756 ALA A1780 LYS A1817	None	0.58A	4uciA-4uclA: 58.4	4uciA-4uclA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UCI_A_SAMA2409_0 (RNA-DIRECTED RNA POLYMERASE L)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	9 / 12	THR A1670 GLY A1696 GLY A1698 GLY A1700 ASN A1701 TRP A1702 SER A1719 LEU A1720 ALA A1756	None	0.83A	4uciA-4uclA: 58.4	4uciA-4uclA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UCI_A_SAMA2409_1 (RNA-DIRECTED RNA POLYMERASE L)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	4 / 4	SER A1668 ASP A1725 ASP A1755 ASP A1779	None	0.58A	4uciA-4uclA: 58.4	4uciA-4uclA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UCI_B_ADNB2415_1 (RNA-DIRECTED RNA POLYMERASE L)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	6 / 7	GLU A1781 PHE A1782 PHE A1788 LYS A1817 TYR A1818 HIS A1819	None	0.60A	4uciB-4uclA: 58.3	4uciB-4uclA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UCI_B_SAMB2409_0 (RNA-DIRECTED RNA POLYMERASE L)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	10 / 12	GLY A1696 GLU A1697 GLY A1698 GLY A1700 ASN A1701 TRP A1702 LEU A1720 ALA A1756 ALA A1780 LYS A1817	None	0.94A	4uciB-4uclA: 58.3	4uciB-4uclA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UCI_B_SAMB2409_0 (RNA-DIRECTED RNA POLYMERASE L)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	10 / 12	GLY A1696 GLU A1697 GLY A1698 GLY A1700 ASN A1701 TRP A1702 SER A1719 LEU A1720 ALA A1756 LYS A1817	None	1.11A	4uciB-4uclA: 58.3	4uciB-4uclA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UCI_B_SAMB2409_0 (RNA-DIRECTED RNA POLYMERASE L)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	10 / 12	THR A1670 GLY A1696 GLY A1698 GLY A1700 ASN A1701 TRP A1702 LEU A1720 ALA A1756 ALA A1780 LYS A1817	None	0.59A	4uciB-4uclA: 58.3	4uciB-4uclA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UCI_B_SAMB2409_0 (RNA-DIRECTED RNA POLYMERASE L)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	10 / 12	THR A1670 GLY A1696 GLY A1698 GLY A1700 ASN A1701 TRP A1702 SER A1719 LEU A1720 ALA A1756 LYS A1817	None	0.82A	4uciB-4uclA: 58.3	4uciB-4uclA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UCI_B_SAMB2409_1 (RNA-DIRECTED RNA POLYMERASE L)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	4 / 4	SER A1668 ASP A1725 ASP A1755 ASP A1779	None	0.58A	4uciB-4uclA: 58.3	4uciB-4uclA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UCK_A_SAMA2409_0 (RNA-DIRECTED RNA POLYMERASE L)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	7 / 12	GLY A1696 GLU A1697 GLY A1698 GLY A1700 LEU A1720 THR A1757 ALA A1780	None	0.95A	4uckA-4uclA: 57.5	4uckA-4uclA: 99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UCK_A_SAMA2409_0 (RNA-DIRECTED RNA POLYMERASE L)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	7 / 12	GLY A1696 GLU A1697 GLY A1698 GLY A1700 SER A1719 LEU A1720 THR A1757	None	1.14A	4uckA-4uclA: 57.5	4uckA-4uclA: 99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UCK_A_SAMA2409_0 (RNA-DIRECTED RNA POLYMERASE L)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	10 / 12	THR A1670 GLY A1696 GLY A1698 GLY A1700 ASN A1701 TRP A1702 LEU A1720 ALA A1756 THR A1757 ALA A1780	None	0.53A	4uckA-4uclA: 57.5	4uckA-4uclA: 99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UCK_A_SAMA2409_0 (RNA-DIRECTED RNA POLYMERASE L)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	10 / 12	THR A1670 GLY A1696 GLY A1698 GLY A1700 ASN A1701 TRP A1702 SER A1719 LEU A1720 ALA A1756 THR A1757	None	0.79A	4uckA-4uclA: 57.5	4uckA-4uclA: 99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UCK_B_SAMB2409_0 (RNA-DIRECTED RNA POLYMERASE L)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	10 / 12	THR A1670 GLY A1698 GLY A1700 ASN A1701 TRP A1702 LEU A1720 ALA A1756 THR A1757 ALA A1780 LYS A1817	None	0.55A	4uckB-4uclA: 58.7	4uckB-4uclA: 99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UCK_B_SAMB2409_0 (RNA-DIRECTED RNA POLYMERASE L)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	10 / 12	THR A1670 GLY A1698 GLY A1700 ASN A1701 TRP A1702 SER A1719 LEU A1720 ALA A1756 THR A1757 LYS A1817	None	0.79A	4uckB-4uclA: 58.7	4uckB-4uclA: 99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UCK_B_SAMB2409_0 (RNA-DIRECTED RNA POLYMERASE L)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	10 / 12	THR A1670 GLY A1700 ASN A1701 TRP A1702 LEU A1720 ASP A1722 ALA A1756 THR A1757 ALA A1780 LYS A1817	None	0.65A	4uckB-4uclA: 58.7	4uckB-4uclA: 99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UCK_B_SAMB2409_0 (RNA-DIRECTED RNA POLYMERASE L)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	10 / 12	THR A1670 GLY A1700 ASN A1701 TRP A1702 SER A1719 LEU A1720 ASP A1722 ALA A1756 THR A1757 LYS A1817	None	0.85A	4uckB-4uclA: 58.7	4uckB-4uclA: 99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UCK_B_SAMB2409_1 (RNA-DIRECTED RNA POLYMERASE L)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	4 / 6	GLY A1696 ASP A1725 ASP A1755 ASP A1779	None	0.69A	4uckB-4uclA: 58.7	4uckB-4uclA: 99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UCK_B_SAMB2409_1 (RNA-DIRECTED RNA POLYMERASE L)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	4 / 6	GLY A1696 GLU A1697 ASP A1755 ASP A1779	None	0.89A	4uckB-4uclA: 58.7	4uckB-4uclA: 99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4UCK_B_SAMB2409_1 (RNA-DIRECTED RNA POLYMERASE L)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	4 / 6	SER A1668 GLY A1696 ASP A1755 ASP A1779	None	0.61A	4uckB-4uclA: 58.7	4uckB-4uclA: 99.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZE1_A_X2NA602_2 (LANOSTEROL 14-ALPHA DEMETHYLASE)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	4 / 5	VAL A1615 TYR A1717 ILE A1695 THR A1670	None	1.32A	4ze1A-4uclA: undetectable	4ze1A-4uclA: 23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZVC_A_BEZA301_0 (DIGUANYLATE CYCLASE DOSC)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	4 / 8	ILE A1680 LEU A1852 ILE A1775 LEU A1687	None	0.72A	4zvcA-4uclA: undetectable 4zvcB-4uclA: undetectable	4zvcA-4uclA: 14.42 4zvcB-4uclA: 14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZVC_A_BEZA301_0 (DIGUANYLATE CYCLASE DOSC)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	4 / 8	ILE A1775 LEU A1687 ILE A1680 LEU A1852	None	0.72A	4zvcA-4uclA: undetectable 4zvcB-4uclA: undetectable	4zvcA-4uclA: 14.42 4zvcB-4uclA: 14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ERG_B_SAMB401_1 (TRNA (ADENINE(58)-N(1))-M ETHYLTRANSFERASE CATALYTIC SUBUNIT TRM61)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	4 / 7	GLY A1696 GLY A1698 ASP A1755 ASP A1779	None	0.62A	5ergB-4uclA: 8.4	5ergB-4uclA: 21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M8R_C_MMSC516_1 (5,6-DIHYDROXYINDOLE- 2-CARBOXYLIC ACID OXIDASE)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	4 / 8	HIS A1761 LEU A1749 GLY A1746 VAL A1716	None	1.01A	5m8rC-4uclA: undetectable	5m8rC-4uclA: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7P_A_ACRA1421_1 (GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	4 / 5	TYR A1717 TYR A1732 GLY A1700 GLY A1698	None	1.08A	5x7pA-4uclA: undetectable	5x7pA-4uclA: 15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YN6_A_SAMA401_0 (NSP16 PROTEIN)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	5 / 12	GLY A1696 LEU A1720 ASP A1755 ASP A1779 PHE A1782	None	1.20A	5yn6A-4uclA: 9.9	5yn6A-4uclA: 22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN5_A_LLLA301_0 (AMINOGLYCOSIDE N(3)-ACETYLTRANSFERA SE, AAC(3)-IVA)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	4 / 6	ASP A1725 GLU A1697 ASP A1779 GLU A1848	None None None SO4 A2409 ( 4.7A)	1.14A	6mn5A-4uclA: undetectable	6mn5A-4uclA: 10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN5_B_LLLB301_0 (AMINOGLYCOSIDE N(3)-ACETYLTRANSFERA SE, AAC(3)-IVA)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	4 / 7	ASP A1725 GLU A1697 ASP A1779 GLU A1848	None None None SO4 A2409 ( 4.7A)	1.06A	6mn5B-4uclA: undetectable	6mn5B-4uclA: 10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN5_C_LLLC301_0 (AMINOGLYCOSIDE N(3)-ACETYLTRANSFERA SE, AAC(3)-IVA)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	4 / 6	ASP A1725 GLU A1697 ASP A1779 GLU A1848	None None None SO4 A2409 ( 4.7A)	0.91A	6mn5C-4uclA: undetectable	6mn5C-4uclA: 10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN5_D_LLLD301_0 (AMINOGLYCOSIDE N(3)-ACETYLTRANSFERA SE, AAC(3)-IVA)	4ucl	RNA-DIRECTED RNA POLYMERASE L (Human metapneumovirus)	4 / 6	ASP A1725 GLU A1697 ASP A1779 GLU A1848	None None None SO4 A2409 ( 4.7A)	1.03A	6mn5D-4uclA: undetectable	6mn5D-4uclA: 10.86

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2B9E_A_SAMA1201_0","NOL1\/NOP2\/SUN DOMAIN FAMILY, MEMBER 5 ISOFORM 2","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",5,"GLY A1700;ASN A1701;LEU A1720;ASP A1755;PHE A1782","None","0.97A","2b9eA-4uclA:7.7","2b9eA-4uclA:20.48"],["2BR4_F_SAMF301_0","CEPHALOSPORIN HYDROXYLASE CMCI","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",5,"GLU A1697;SER A1668;ASP A1755;ASP A1779;ALA A1780","None","1.05A","2br4F-4uclA:9.6","2br4F-4uclA:18.34"],["2FK8_A_SAMA302_0","METHOXY MYCOLIC ACID SYNTHASE 4","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",5,"ILE A1695;GLY A1696;GLY A1698;LEU A1720;ALA A1780","None","0.67A","2fk8A-4uclA:7.2","2fk8A-4uclA:25.11"],["2NYU_A_SAMA201_0","PUTATIVE RIBOSOMAL RNA METHYLTRANSFERASE 2","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",5,"GLY A1696;GLY A1700;TRP A1702;LEU A1720;LYS A1817","None","0.95A","2nyuA-4uclA:10.2","2nyuA-4uclA:16.87"],["2NYU_B_SAMB201_0","PUTATIVE RIBOSOMAL RNA METHYLTRANSFERASE 2","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",6,"GLY A1696;GLY A1700;TRP A1702;LEU A1720;THR A1757;LYS A1817","None","1.03A","2nyuB-4uclA:9.9","2nyuB-4uclA:16.87"],["2OK6_H_BEZH2001_0","AROMATIC AMINE DEHYDROGENASE, LARGE SUBUNIT;AROMATIC AMINE DEHYDROGENASE, SMALL SUBUNIT","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",5,"PHE A1968;GLY A1998;LEU A2001;ASN A1661;PHE A1880","None","1.47A","2ok6A-4uclA:undetectable;2ok6H-4uclA:undetectable","2ok6A-4uclA:22.27;2ok6H-4uclA:15.18"],["2OXT_C_SAMC300_0","NUCLEOSIDE-2'-O-METHYLTRANSFERASE","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",5,"GLY A1696;GLY A1698;LEU A1720;ASP A1779;LYS A1817","None","0.96A","2oxtC-4uclA:11.0","2oxtC-4uclA:21.04"],["2WA2_B_SAMB1267_0","NON-STRUCTURAL PROTEIN 5","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",5,"GLY A1696;GLY A1698;LEU A1720;THR A1757;ASP A1779","None","0.96A","2wa2B-4uclA:10.5","2wa2B-4uclA:21.08"],["3DOU_A_SAMA1_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",5,"GLY A1696;GLY A1700;LEU A1720;ALA A1780;LYS A1817","None","0.50A","3douA-4uclA:9.4","3douA-4uclA:20.52"],["3IHT_A_SAMA200_0","S-ADENOSYL-L-METHIONINE METHYL TRANSFERASE","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",5,"GLY A1696;GLY A1698;GLY A1700;ASP A1755;ASP A1779","None","0.73A","3ihtA-4uclA:7.6","3ihtA-4uclA:19.50"],["3L8L_B_DVAB6_0","GRAMICIDIN D","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",3,"TRP A1795;ALA A1756;VAL A1792","None","0.96A","3l8lA-4uclA:undetectable;3l8lB-4uclA:undetectable","3l8lA-4uclA:28.00;3l8lB-4uclA:3.79"],["3OKX_B_SAMB201_0","YAEB-LIKE PROTEIN RPA0152","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",3,"LYS A1991;ARG A1662;LYS A1871","SO4 A2409 (-3.1A);SO4 A2409 (-3.1A);None","1.33A","3okxA-4uclA:undetectable","3okxA-4uclA:17.87"],["3QPK_A_CUA601_0","LACCASE-1","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",4,"HIS A1798;CYH A1805;ILE A1804;LEU A1773"," ZN A2408 (-3.3A); ZN A2408 (-2.3A); ZN A2408 ( 4.5A);None","1.34A","3qpkA-4uclA:undetectable","3qpkA-4uclA:19.93"],["3R24_A_SAMA302_0","2'-O-METHYL TRANSFERASE","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",5,"GLY A1696;LEU A1720;ASP A1755;PHE A1782;LYS A1817","None","1.29A","3r24A-4uclA:10.0","3r24A-4uclA:undetectable"],["3S3V_A_TOPA193_1","DIHYDROFOLATE REDUCTASE","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",4,"LEU A1814;ILE A1793;PRO A1828;PHE A1789","None","1.12A","3s3vA-4uclA:undetectable","3s3vA-4uclA:20.26"],["3T3S_E_9PLE1_1","CYTOCHROME P450 2A13","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",4,"ALA A1704;ASN A1701;PHE A1667;ALA A1699","None","1.12A","3t3sE-4uclA:undetectable","3t3sE-4uclA:21.30"],["4KRH_A_SAMA900_0","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE 2","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",5,"GLY A1696;GLY A1698;LEU A1720;ASP A1755;ALA A1756","None","0.63A","4krhA-4uclA:7.6","4krhA-4uclA:23.33"],["4UCI_A_ADNA2414_1","RNA-DIRECTED RNA POLYMERASE L","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",5,"GLU A1781;PHE A1782;PHE A1788;TYR A1818;HIS A1819","None","0.51A","4uciA-4uclA:58.4","4uciA-4uclA:100.00"],["4UCI_A_SAMA2409_0","RNA-DIRECTED RNA POLYMERASE L","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",10,"GLY A1696;GLU A1697;GLY A1698;GLY A1700;ASN A1701;TRP A1702;LEU A1720;ALA A1756;ALA A1780;LYS A1817","None","0.94A","4uciA-4uclA:58.4","4uciA-4uclA:100.00"],["4UCI_A_SAMA2409_0","RNA-DIRECTED RNA POLYMERASE L","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",9,"GLY A1696;GLU A1697;GLY A1698;GLY A1700;ASN A1701;TRP A1702;SER A1719;LEU A1720;ALA A1756","None","1.16A","4uciA-4uclA:58.4","4uciA-4uclA:100.00"],["4UCI_A_SAMA2409_0","RNA-DIRECTED RNA POLYMERASE L","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",10,"THR A1670;GLY A1696;GLY A1698;GLY A1700;ASN A1701;TRP A1702;LEU A1720;ALA A1756;ALA A1780;LYS A1817","None","0.58A","4uciA-4uclA:58.4","4uciA-4uclA:100.00"],["4UCI_A_SAMA2409_0","RNA-DIRECTED RNA POLYMERASE L","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",9,"THR A1670;GLY A1696;GLY A1698;GLY A1700;ASN A1701;TRP A1702;SER A1719;LEU A1720;ALA A1756","None","0.83A","4uciA-4uclA:58.4","4uciA-4uclA:100.00"],["4UCI_A_SAMA2409_1","RNA-DIRECTED RNA POLYMERASE L","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",4,"SER A1668;ASP A1725;ASP A1755;ASP A1779","None","0.58A","4uciA-4uclA:58.4","4uciA-4uclA:100.00"],["4UCI_B_ADNB2415_1","RNA-DIRECTED RNA POLYMERASE L","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",6,"GLU A1781;PHE A1782;PHE A1788;LYS A1817;TYR A1818;HIS A1819","None","0.60A","4uciB-4uclA:58.3","4uciB-4uclA:100.00"],["4UCI_B_SAMB2409_0","RNA-DIRECTED RNA POLYMERASE L","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",10,"GLY A1696;GLU A1697;GLY A1698;GLY A1700;ASN A1701;TRP A1702;LEU A1720;ALA A1756;ALA A1780;LYS A1817","None","0.94A","4uciB-4uclA:58.3","4uciB-4uclA:100.00"],["4UCI_B_SAMB2409_0","RNA-DIRECTED RNA POLYMERASE L","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",10,"GLY A1696;GLU A1697;GLY A1698;GLY A1700;ASN A1701;TRP A1702;SER A1719;LEU A1720;ALA A1756;LYS A1817","None","1.11A","4uciB-4uclA:58.3","4uciB-4uclA:100.00"],["4UCI_B_SAMB2409_0","RNA-DIRECTED RNA POLYMERASE L","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",10,"THR A1670;GLY A1696;GLY A1698;GLY A1700;ASN A1701;TRP A1702;LEU A1720;ALA A1756;ALA A1780;LYS A1817","None","0.59A","4uciB-4uclA:58.3","4uciB-4uclA:100.00"],["4UCI_B_SAMB2409_0","RNA-DIRECTED RNA POLYMERASE L","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",10,"THR A1670;GLY A1696;GLY A1698;GLY A1700;ASN A1701;TRP A1702;SER A1719;LEU A1720;ALA A1756;LYS A1817","None","0.82A","4uciB-4uclA:58.3","4uciB-4uclA:100.00"],["4UCI_B_SAMB2409_1","RNA-DIRECTED RNA POLYMERASE L","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",4,"SER A1668;ASP A1725;ASP A1755;ASP A1779","None","0.58A","4uciB-4uclA:58.3","4uciB-4uclA:100.00"],["4UCK_A_SAMA2409_0","RNA-DIRECTED RNA POLYMERASE L","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",7,"GLY A1696;GLU A1697;GLY A1698;GLY A1700;LEU A1720;THR A1757;ALA A1780","None","0.95A","4uckA-4uclA:57.5","4uckA-4uclA:99.76"],["4UCK_A_SAMA2409_0","RNA-DIRECTED RNA POLYMERASE L","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",7,"GLY A1696;GLU A1697;GLY A1698;GLY A1700;SER A1719;LEU A1720;THR A1757","None","1.14A","4uckA-4uclA:57.5","4uckA-4uclA:99.76"],["4UCK_A_SAMA2409_0","RNA-DIRECTED RNA POLYMERASE L","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",10,"THR A1670;GLY A1696;GLY A1698;GLY A1700;ASN A1701;TRP A1702;LEU A1720;ALA A1756;THR A1757;ALA A1780","None","0.53A","4uckA-4uclA:57.5","4uckA-4uclA:99.76"],["4UCK_A_SAMA2409_0","RNA-DIRECTED RNA POLYMERASE L","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",10,"THR A1670;GLY A1696;GLY A1698;GLY A1700;ASN A1701;TRP A1702;SER A1719;LEU A1720;ALA A1756;THR A1757","None","0.79A","4uckA-4uclA:57.5","4uckA-4uclA:99.76"],["4UCK_B_SAMB2409_0","RNA-DIRECTED RNA POLYMERASE L","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",10,"THR A1670;GLY A1698;GLY A1700;ASN A1701;TRP A1702;LEU A1720;ALA A1756;THR A1757;ALA A1780;LYS A1817","None","0.55A","4uckB-4uclA:58.7","4uckB-4uclA:99.76"],["4UCK_B_SAMB2409_0","RNA-DIRECTED RNA POLYMERASE L","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",10,"THR A1670;GLY A1698;GLY A1700;ASN A1701;TRP A1702;SER A1719;LEU A1720;ALA A1756;THR A1757;LYS A1817","None","0.79A","4uckB-4uclA:58.7","4uckB-4uclA:99.76"],["4UCK_B_SAMB2409_0","RNA-DIRECTED RNA POLYMERASE L","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",10,"THR A1670;GLY A1700;ASN A1701;TRP A1702;LEU A1720;ASP A1722;ALA A1756;THR A1757;ALA A1780;LYS A1817","None","0.65A","4uckB-4uclA:58.7","4uckB-4uclA:99.76"],["4UCK_B_SAMB2409_0","RNA-DIRECTED RNA POLYMERASE L","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",10,"THR A1670;GLY A1700;ASN A1701;TRP A1702;SER A1719;LEU A1720;ASP A1722;ALA A1756;THR A1757;LYS A1817","None","0.85A","4uckB-4uclA:58.7","4uckB-4uclA:99.76"],["4UCK_B_SAMB2409_1","RNA-DIRECTED RNA POLYMERASE L","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",4,"GLY A1696;ASP A1725;ASP A1755;ASP A1779","None","0.69A","4uckB-4uclA:58.7","4uckB-4uclA:99.76"],["4UCK_B_SAMB2409_1","RNA-DIRECTED RNA POLYMERASE L","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",4,"GLY A1696;GLU A1697;ASP A1755;ASP A1779","None","0.89A","4uckB-4uclA:58.7","4uckB-4uclA:99.76"],["4UCK_B_SAMB2409_1","RNA-DIRECTED RNA POLYMERASE L","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",4,"SER A1668;GLY A1696;ASP A1755;ASP A1779","None","0.61A","4uckB-4uclA:58.7","4uckB-4uclA:99.76"],["4ZE1_A_X2NA602_2","LANOSTEROL 14-ALPHA DEMETHYLASE","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",4,"VAL A1615;TYR A1717;ILE A1695;THR A1670","None","1.32A","4ze1A-4uclA:undetectable","4ze1A-4uclA:23.24"],["4ZVC_A_BEZA301_0","DIGUANYLATE CYCLASE DOSC","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",4,"ILE A1680;LEU A1852;ILE A1775;LEU A1687","None","0.72A","4zvcA-4uclA:undetectable;4zvcB-4uclA:undetectable","4zvcA-4uclA:14.42;4zvcB-4uclA:14.42"],["4ZVC_A_BEZA301_0","DIGUANYLATE CYCLASE DOSC","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",4,"ILE A1775;LEU A1687;ILE A1680;LEU A1852","None","0.72A","4zvcA-4uclA:undetectable;4zvcB-4uclA:undetectable","4zvcA-4uclA:14.42;4zvcB-4uclA:14.42"],["5ERG_B_SAMB401_1","TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRM61","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",4,"GLY A1696;GLY A1698;ASP A1755;ASP A1779","None","0.62A","5ergB-4uclA:8.4","5ergB-4uclA:21.48"],["5M8R_C_MMSC516_1","5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACID OXIDASE","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",4,"HIS A1761;LEU A1749;GLY A1746;VAL A1716","None","1.01A","5m8rC-4uclA:undetectable","5m8rC-4uclA:21.10"],["5X7P_A_ACRA1421_1","GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",4,"TYR A1717;TYR A1732;GLY A1700;GLY A1698","None","1.08A","5x7pA-4uclA:undetectable","5x7pA-4uclA:15.04"],["5YN6_A_SAMA401_0","NSP16 PROTEIN","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",5,"GLY A1696;LEU A1720;ASP A1755;ASP A1779;PHE A1782","None","1.20A","5yn6A-4uclA:9.9","5yn6A-4uclA:22.51"],["6MN5_A_LLLA301_0","AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE, AAC(3)-IVA","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",4,"ASP A1725;GLU A1697;ASP A1779;GLU A1848","None;None;None;SO4 A2409 ( 4.7A)","1.14A","6mn5A-4uclA:undetectable","6mn5A-4uclA:10.86"],["6MN5_B_LLLB301_0","AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE, AAC(3)-IVA","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",4,"ASP A1725;GLU A1697;ASP A1779;GLU A1848","None;None;None;SO4 A2409 ( 4.7A)","1.06A","6mn5B-4uclA:undetectable","6mn5B-4uclA:10.86"],["6MN5_C_LLLC301_0","AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE, AAC(3)-IVA","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",4,"ASP A1725;GLU A1697;ASP A1779;GLU A1848","None;None;None;SO4 A2409 ( 4.7A)","0.91A","6mn5C-4uclA:undetectable","6mn5C-4uclA:10.86"],["6MN5_D_LLLD301_0","AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE, AAC(3)-IVA","4ucl","RNA-DIRECTED RNA POLYMERASE L","Human metapneumovirus",4,"ASP A1725;GLU A1697;ASP A1779;GLU A1848","None;None;None;SO4 A2409 ( 4.7A)","1.03A","6mn5D-4uclA:undetectable","6mn5D-4uclA:10.86"]]