SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ucw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KQB_B_BEZB525_0 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	4ucw	HYDROGENASE (NIFE) SMALL SUBUNIT HYDA (Desulfovibrio fructosivorans)	4 / 5	GLU A 250 GLY A 247 THR A 256 PHE A 253	None F3S A1266 (-4.6A) None None	1.27A	1kqbA-4ucwA: undetectable 1kqbB-4ucwA: undetectable	1kqbA-4ucwA: 22.38 1kqbB-4ucwA: 22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXD_A_ACRA732_1 (ALPHA AMYLASE)	4ucw	HYDROGENASE (NIFE) SMALL SUBUNIT HYDA (Desulfovibrio fructosivorans)	5 / 9	GLY A 247 PRO A 145 GLY A 146 GLY A 119 GLY A 118	F3S A1266 (-4.6A) None None None None	1.05A	1mxdA-4ucwA: undetectable	1mxdA-4ucwA: 22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WG8_A_SAMA3142_0 (PREDICTED S-ADENOSYLMETHIONINE -DEPENDENT METHYLTRANSFERASE)	4ucw	HYDROGENASE (NIFE) SMALL SUBUNIT HYDA (Desulfovibrio fructosivorans)	5 / 12	GLY A 76 GLY A 77 GLY A 132 PHE A 154 HIS A 13	SF4 A1267 ( 4.9A) None None None None	1.03A	1wg8A-4ucwA: undetectable	1wg8A-4ucwA: 22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WG8_B_SAMB3141_0 (PREDICTED S-ADENOSYLMETHIONINE -DEPENDENT METHYLTRANSFERASE)	4ucw	HYDROGENASE (NIFE) SMALL SUBUNIT HYDA (Desulfovibrio fructosivorans)	5 / 12	GLY A 76 GLY A 77 GLY A 132 PHE A 154 HIS A 13	SF4 A1267 ( 4.9A) None None None None	0.99A	1wg8B-4ucwA: undetectable	1wg8B-4ucwA: 22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YA4_C_CTXC3_1 (CES1 PROTEIN)	4ucw	HYDROGENASE (NIFE) SMALL SUBUNIT HYDA (Desulfovibrio fructosivorans)	5 / 12	LEU A 42 SER A 41 LEU A 35 LEU A 72 LEU A 162	None	1.06A	1ya4C-4ucwA: undetectable	1ya4C-4ucwA: 17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DCM_X_SAMX5452_0 (UNCHARACTERIZED PROTEIN TM_1570)	4ucw	HYDROGENASE (NIFE) SMALL SUBUNIT HYDA (Desulfovibrio fructosivorans)	5 / 11	ALA A 116 GLY A 119 ILE A 144 ASN A 143 SER A 249	None None None None F3S A1266 ( 4.0A)	0.91A	3dcmX-4ucwA: undetectable	3dcmX-4ucwA: 21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FPJ_B_SAMB301_1 (PUTATIVE UNCHARACTERIZED PROTEIN)	4ucw	HYDROGENASE (NIFE) SMALL SUBUNIT HYDA (Desulfovibrio fructosivorans)	4 / 7	GLY A 132 GLY A 77 THR A 80 ALA A 136	None	0.86A	3fpjB-4ucwA: undetectable	3fpjB-4ucwA: 20.06

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1KQB_B_BEZB525_0","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","4ucw","HYDROGENASE (NIFE) SMALL SUBUNIT HYDA","Desulfovibrio fructosivorans",4,"GLU A 250;GLY A 247;THR A 256;PHE A 253","None;F3S A1266 (-4.6A);None;None","1.27A","1kqbA-4ucwA:undetectable;1kqbB-4ucwA:undetectable","1kqbA-4ucwA:22.38;1kqbB-4ucwA:22.38"],["1MXD_A_ACRA732_1","ALPHA AMYLASE","4ucw","HYDROGENASE (NIFE) SMALL SUBUNIT HYDA","Desulfovibrio fructosivorans",5,"GLY A 247;PRO A 145;GLY A 146;GLY A 119;GLY A 118","F3S A1266 (-4.6A);None;None;None;None","1.05A","1mxdA-4ucwA:undetectable","1mxdA-4ucwA:22.10"],["1WG8_A_SAMA3142_0","PREDICTED S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE","4ucw","HYDROGENASE (NIFE) SMALL SUBUNIT HYDA","Desulfovibrio fructosivorans",5,"GLY A  76;GLY A  77;GLY A 132;PHE A 154;HIS A  13","SF4 A1267 ( 4.9A);None;None;None;None","1.03A","1wg8A-4ucwA:undetectable","1wg8A-4ucwA:22.47"],["1WG8_B_SAMB3141_0","PREDICTED S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE","4ucw","HYDROGENASE (NIFE) SMALL SUBUNIT HYDA","Desulfovibrio fructosivorans",5,"GLY A  76;GLY A  77;GLY A 132;PHE A 154;HIS A  13","SF4 A1267 ( 4.9A);None;None;None;None","0.99A","1wg8B-4ucwA:undetectable","1wg8B-4ucwA:22.47"],["1YA4_C_CTXC3_1","CES1 PROTEIN","4ucw","HYDROGENASE (NIFE) SMALL SUBUNIT HYDA","Desulfovibrio fructosivorans",5,"LEU A  42;SER A  41;LEU A  35;LEU A  72;LEU A 162","None","1.06A","1ya4C-4ucwA:undetectable","1ya4C-4ucwA:17.38"],["3DCM_X_SAMX5452_0","UNCHARACTERIZED PROTEIN TM_1570","4ucw","HYDROGENASE (NIFE) SMALL SUBUNIT HYDA","Desulfovibrio fructosivorans",5,"ALA A 116;GLY A 119;ILE A 144;ASN A 143;SER A 249","None;None;None;None;F3S A1266 ( 4.0A)","0.91A","3dcmX-4ucwA:undetectable","3dcmX-4ucwA:21.29"],["3FPJ_B_SAMB301_1","PUTATIVE UNCHARACTERIZED PROTEIN","4ucw","HYDROGENASE (NIFE) SMALL SUBUNIT HYDA","Desulfovibrio fructosivorans",4,"GLY A 132;GLY A  77;THR A  80;ALA A 136","None","0.86A","3fpjB-4ucwA:undetectable","3fpjB-4ucwA:20.06"]]