SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ud8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		4 / 6 SER A 312
GLY A 356
THR A 262
ILE A 354
 PE5  A 901 (-3.6A)
PE5  A 901 ( 3.8A)
None
None
 0.79A 1gtnD-4ud8A:
undetectable
1gtnE-4ud8A:
undetectable		 1gtnD-4ud8A:
10.22
1gtnE-4ud8A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		4 / 7 SER A 312
GLY A 356
THR A 262
ILE A 354
 PE5  A 901 (-3.6A)
PE5  A 901 ( 3.8A)
None
None
 0.86A 1gtnF-4ud8A:
undetectable
1gtnG-4ud8A:
undetectable		 1gtnF-4ud8A:
10.22
1gtnG-4ud8A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		4 / 7 SER A 312
GLY A 356
THR A 262
ILE A 354
 PE5  A 901 (-3.6A)
PE5  A 901 ( 3.8A)
None
None
 0.88A 1gtnJ-4ud8A:
undetectable
1gtnK-4ud8A:
undetectable		 1gtnJ-4ud8A:
10.22
1gtnK-4ud8A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 ILE A 233
ILE A 212
MET A 225
ALA A 223
ARG A 234
 None
 1.48A 1ki7B-4ud8A:
undetectable		 1ki7B-4ud8A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 ARG A 198
PHE A 317
ALA A 315
LEU A 335
LEU A 285
 None
 1.14A 1og5A-4ud8A:
undetectable		 1og5A-4ud8A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 VAL A  99
ALA A  96
HIS A  93
 None
 0.79A 1q23L-4ud8A:
undetectable		 1q23L-4ud8A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		4 / 6 ARG A 234
GLU A 424
ILE A 425
PRO A 426
 None
 1.03A 2fcnA-4ud8A:
undetectable
2fcnB-4ud8A:
undetectable		 2fcnA-4ud8A:
10.15
2fcnB-4ud8A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 11 ILE A 184
GLY A 114
HIS A 115
THR A 157
GLY A 185
 None
FAD  A 601 (-3.2A)
FAD  A 601 (-2.5A)
None
FAD  A 601 (-3.6A)
 1.23A 2fn1B-4ud8A:
undetectable		 2fn1B-4ud8A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 11 VAL A 254
VAL A 351
SER A 169
ILE A 348
ALA A 176
 None
 1.25A 2zbzA-4ud8A:
undetectable		 2zbzA-4ud8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 ASN A 478
GLY A 236
GLY A 190
LEU A 508
TYR A 500
 FAD  A 601 (-3.7A)
None
None
None
None
 1.21A 2zw9A-4ud8A:
undetectable		 2zw9A-4ud8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 GLU A 279
LEU A 275
ILE A 309
LEU A 267
TYR A 463
 None
 1.09A 2zzaA-4ud8A:
undetectable		 2zzaA-4ud8A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 11 GLU A 279
LEU A 275
ILE A 309
LEU A 267
TYR A 463
 None
 1.07A 2zzaB-4ud8A:
undetectable		 2zzaB-4ud8A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 CYH A 179
SER A 180
LEU A 182
THR A 157
GLN A  70
 FAD  A 601 (-1.7A)
None
FAD  A 601 (-4.5A)
None
None
 1.15A 3a35B-4ud8A:
undetectable		 3a35B-4ud8A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 GLU A 279
LEU A 275
ILE A 309
LEU A 267
TYR A 463
 None
 1.09A 3datA-4ud8A:
undetectable		 3datA-4ud8A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 LEU A 108
LEU A 245
VAL A 213
VAL A 243
LEU A 135
 None
None
None
FAD  A 601 ( 4.2A)
FAD  A 601 (-4.7A)
 0.94A 3gwxB-4ud8A:
undetectable		 3gwxB-4ud8A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 GLU A 279
LEU A 275
ILE A 309
LEU A 267
TYR A 463
 None
 1.13A 3ia4A-4ud8A:
undetectable		 3ia4A-4ud8A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 GLU A 279
LEU A 275
ILE A 309
LEU A 267
TYR A 463
 None
 1.10A 3ia4B-4ud8A:
undetectable		 3ia4B-4ud8A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 GLU A 279
LEU A 275
ILE A 309
LEU A 267
TYR A 463
 None
 1.12A 3ia4C-4ud8A:
undetectable		 3ia4C-4ud8A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 GLU A 279
LEU A 275
ILE A 309
LEU A 267
TYR A 463
 None
 1.12A 3ia4D-4ud8A:
undetectable		 3ia4D-4ud8A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 9 GLY A 191
ALA A 192
ILE A 158
GLY A 185
ILE A 244
 None
FAD  A 601 (-4.3A)
None
FAD  A 601 (-3.6A)
FAD  A 601 (-3.8A)
 0.90A 3s53A-4ud8A:
undetectable		 3s53A-4ud8A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		4 / 8 LEU A  75
PHE A 377
ASP A 116
TYR A  74
 None
PE5  A 901 (-3.9A)
FAD  A 601 (-4.1A)
None
 0.92A 4drjB-4ud8A:
undetectable		 4drjB-4ud8A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 SER A 112
GLY A 237
ILE A 233
ALA A 232
VAL A 229
 FAD  A 601 (-2.7A)
None
None
None
None
 1.12A 4dx5B-4ud8A:
undetectable		 4dx5B-4ud8A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		4 / 5 ARG A 452
TRP A 456
ILE A 457
ASN A  71
 None
 1.33A 4i00A-4ud8A:
undetectable		 4i00A-4ud8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 ARG A  73
GLU A 118
ASN A  71
 None
 0.87A 4imaD-4ud8A:
undetectable		 4imaD-4ud8A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 ARG A  73
GLU A 118
ASN A  71
 None
 0.89A 4ip7D-4ud8A:
undetectable		 4ip7D-4ud8A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 ILE A 158
GLY A 203
ALA A 204
ALA A 210
ILE A 244
 None
None
None
None
FAD  A 601 (-3.8A)
 0.99A 4nkxC-4ud8A:
undetectable		 4nkxC-4ud8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 ILE A 158
GLY A 203
ALA A 204
ALA A 210
ILE A 244
 None
None
None
None
FAD  A 601 (-3.8A)
 0.97A 4nkxD-4ud8A:
undetectable		 4nkxD-4ud8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 LEU A 393
GLY A 395
THR A 408
ILE A 295
PHE A 400
 None
 0.76A 4p6xI-4ud8A:
undetectable		 4p6xI-4ud8A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 SER A 112
GLY A 237
ILE A 233
ALA A 232
VAL A 229
 FAD  A 601 (-2.7A)
None
None
None
None
 1.15A 4u95B-4ud8A:
undetectable		 4u95B-4ud8A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		4 / 5 ASP A 516
PHE A 520
PHE A 521
VAL A  98
 None
 1.04A 5a1rA-4ud8A:
undetectable		 5a1rA-4ud8A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 TYR A 476
GLY A 238
LEU A 110
SER A 121
VAL A 189
 FAD  A 601 (-4.6A)
FAD  A 601 (-3.4A)
FAD  A 601 (-4.4A)
FAD  A 601 (-2.4A)
None
 1.11A 5dpdA-4ud8A:
undetectable		 5dpdA-4ud8A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 TYR A 476
GLY A 238
LEU A 110
SER A 121
VAL A 189
 FAD  A 601 (-4.6A)
FAD  A 601 (-3.4A)
FAD  A 601 (-4.4A)
FAD  A 601 (-2.4A)
None
 1.17A 5dpdB-4ud8A:
undetectable		 5dpdB-4ud8A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 LEU A 178
LYS A 436
HIS A 187
GLY A 201
PHE A 290
 FAD  A 601 (-3.9A)
None
FAD  A 601 (-4.0A)
None
None
 1.43A 5hm8A-4ud8A:
undetectable		 5hm8A-4ud8A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 LEU A 178
LYS A 436
HIS A 187
GLY A 201
PHE A 290
 FAD  A 601 (-3.9A)
None
FAD  A 601 (-4.0A)
None
None
 1.43A 5hm8B-4ud8A:
undetectable		 5hm8B-4ud8A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 LEU A 178
LYS A 436
HIS A 187
GLY A 201
PHE A 290
 FAD  A 601 (-3.9A)
None
FAD  A 601 (-4.0A)
None
None
 1.43A 5hm8C-4ud8A:
undetectable		 5hm8C-4ud8A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 LEU A 178
LYS A 436
HIS A 187
GLY A 201
PHE A 290
 FAD  A 601 (-3.9A)
None
FAD  A 601 (-4.0A)
None
None
 1.43A 5hm8D-4ud8A:
undetectable		 5hm8D-4ud8A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 LEU A 178
LYS A 436
HIS A 187
GLY A 201
PHE A 290
 FAD  A 601 (-3.9A)
None
FAD  A 601 (-4.0A)
None
None
 1.43A 5hm8E-4ud8A:
undetectable		 5hm8E-4ud8A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 LEU A 178
LYS A 436
HIS A 187
GLY A 201
PHE A 290
 FAD  A 601 (-3.9A)
None
FAD  A 601 (-4.0A)
None
None
 1.43A 5hm8F-4ud8A:
undetectable		 5hm8F-4ud8A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 LEU A 178
LYS A 436
HIS A 187
GLY A 201
PHE A 290
 FAD  A 601 (-3.9A)
None
FAD  A 601 (-4.0A)
None
None
 1.43A 5hm8G-4ud8A:
undetectable		 5hm8G-4ud8A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 LEU A 178
LYS A 436
HIS A 187
GLY A 201
PHE A 290
 FAD  A 601 (-3.9A)
None
FAD  A 601 (-4.0A)
None
None
 1.43A 5hm8H-4ud8A:
undetectable		 5hm8H-4ud8A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_C_PFLC407_1
(PROTON-GATED ION
CHANNEL)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 9 TYR A 463
TYR A 467
ILE A 388
TRP A 410
TYR A 461
 None
 1.13A 5mvnC-4ud8A:
0.2		 5mvnC-4ud8A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		5 / 10 TYR A 463
TYR A 467
ILE A 388
TRP A 410
TYR A 461
 None
 1.14A 5mvnD-4ud8A:
undetectable		 5mvnD-4ud8A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 GLY A 183
LEU A 182
HIS A 115
 FAD  A 601 (-3.6A)
FAD  A 601 (-4.5A)
FAD  A 601 (-2.5A)
 0.58A 5u63A-4ud8A:
undetectable		 5u63A-4ud8A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		3 / 3 GLY A 183
LEU A 182
HIS A 115
 FAD  A 601 (-3.6A)
FAD  A 601 (-4.5A)
FAD  A 601 (-2.5A)
 0.65A 5u63B-4ud8A:
undetectable		 5u63B-4ud8A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN
(Arabidopsis
thaliana) 		4 / 8 ARG A 111
HIS A 115
ASP A 134
GLU A  64
 None
FAD  A 601 (-2.5A)
None
None
 1.21A 6mn4C-4ud8A:
undetectable		 6mn4C-4ud8A:
17.50