SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4udr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 6 LEU A 215
ILE A 263
ARG A 497
VAL A  32
 None
 1.10A 1db1A-4udrA:
undetectable		 1db1A-4udrA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 12 LEU A  71
PRO A 390
VAL A 392
ALA A 468
PHE A 394
 None
 1.24A 1gseA-4udrA:
undetectable		 1gseA-4udrA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 12 LEU A 269
GLY A 463
TYR A  89
ILE A  73
THR A 376
 None
 1.12A 1p91B-4udrA:
undetectable		 1p91B-4udrA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 11 LEU A 264
ARG A 277
VAL A 300
GLY A 301
ALA A 472
 None
 1.28A 2bxgA-4udrA:
undetectable		 2bxgA-4udrA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 12 PHE A 394
ALA A 266
GLY A  92
GLY A  14
TRP A  68
 None
FAD  A 700 (-3.6A)
None
FAD  A 700 (-3.2A)
FAD  A 700 (-4.1A)
 1.08A 2igtA-4udrA:
2.8		 2igtA-4udrA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 12 PHE A 394
ALA A 266
GLY A  92
GLY A  14
TRP A  68
 None
FAD  A 700 (-3.6A)
None
FAD  A 700 (-3.2A)
FAD  A 700 (-4.1A)
 1.08A 2igtB-4udrA:
2.8		 2igtB-4udrA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 12 SER A  18
GLY A  12
GLY A  13
ALA A 211
GLY A  38
 None
FAD  A 700 (-3.2A)
FAD  A 700 ( 4.8A)
None
None
 0.73A 2pkkA-4udrA:
3.2		 2pkkA-4udrA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 12 SER A  18
GLY A  12
GLY A  13
ALA A 211
GLY A  38
 None
FAD  A 700 (-3.2A)
FAD  A 700 ( 4.8A)
None
None
 0.74A 2pkmA-4udrA:
undetectable		 2pkmA-4udrA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 6 LEU A 444
LEU A 447
ILE A 413
ARG A 411
 None
 0.92A 2rlfB-4udrA:
undetectable
2rlfC-4udrA:
undetectable		 2rlfB-4udrA:
6.68
2rlfC-4udrA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		3 / 3 PRO A 272
LEU A 275
ARG A 297
 None
None
FMT  A1530 (-3.0A)
 0.84A 3aqiB-4udrA:
undetectable		 3aqiB-4udrA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 10 GLY A 213
THR A 201
THR A  15
LEU A 517
THR A 137
 None
None
FAD  A 700 (-3.8A)
None
None
 1.30A 3bexA-4udrA:
undetectable
3bexB-4udrA:
undetectable		 3bexA-4udrA:
19.74
3bexB-4udrA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 11 GLY A 213
THR A 201
THR A  15
LEU A 517
THR A 137
 None
None
FAD  A 700 (-3.8A)
None
None
 1.29A 3bexC-4udrA:
undetectable
3bexD-4udrA:
undetectable		 3bexC-4udrA:
19.74
3bexD-4udrA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 11 THR A  15
LEU A 517
THR A 137
GLY A 213
THR A 201
 FAD  A 700 (-3.8A)
None
None
None
None
 1.29A 3bexE-4udrA:
undetectable
3bexF-4udrA:
undetectable		 3bexE-4udrA:
19.74
3bexF-4udrA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 11 GLY A 213
THR A 201
THR A  15
LEU A 517
THR A 137
 None
None
FAD  A 700 (-3.8A)
None
None
 1.28A 3bf1A-4udrA:
undetectable
3bf1B-4udrA:
undetectable		 3bf1A-4udrA:
19.74
3bf1B-4udrA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 11 GLY A 213
THR A 201
THR A  15
LEU A 517
THR A 137
 None
None
FAD  A 700 (-3.8A)
None
None
 1.29A 3bf1C-4udrA:
undetectable
3bf1D-4udrA:
undetectable		 3bf1C-4udrA:
19.74
3bf1D-4udrA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 11 THR A  15
LEU A 517
THR A 137
GLY A 213
THR A 201
 FAD  A 700 (-3.8A)
None
None
None
None
 1.31A 3bf1C-4udrA:
undetectable
3bf1D-4udrA:
undetectable		 3bf1C-4udrA:
19.74
3bf1D-4udrA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 11 GLY A 213
THR A 201
THR A  15
LEU A 517
THR A 137
 None
None
FAD  A 700 (-3.8A)
None
None
 1.31A 3bf1E-4udrA:
undetectable
3bf1F-4udrA:
undetectable		 3bf1E-4udrA:
19.74
3bf1F-4udrA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 11 THR A  15
LEU A 517
THR A 137
GLY A 213
THR A 201
 FAD  A 700 (-3.8A)
None
None
None
None
 1.31A 3bf1E-4udrA:
undetectable
3bf1F-4udrA:
undetectable		 3bf1E-4udrA:
19.74
3bf1F-4udrA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 7 GLU A 306
SER A 308
VAL A 465
TRP A 369
 None
 1.22A 3dqtA-4udrA:
undetectable
3dqtB-4udrA:
undetectable		 3dqtA-4udrA:
23.67
3dqtB-4udrA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 9 LEU A 528
GLY A 488
ALA A 499
THR A 265
ILE A  10
 None
 1.45A 3jusB-4udrA:
undetectable		 3jusB-4udrA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 8 GLU A 306
SER A 308
VAL A 370
TRP A 369
 None
 1.27A 3jx1A-4udrA:
undetectable
3jx1B-4udrA:
undetectable		 3jx1A-4udrA:
22.40
3jx1B-4udrA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 7 SER A 308
LEU A 412
ILE A 310
PHE A 368
 None
 1.07A 3ln1C-4udrA:
undetectable		 3ln1C-4udrA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 8 ASP A 350
PHE A 368
LEU A 403
ASP A 402
 None
 0.92A 3m0wE-4udrA:
undetectable
3m0wF-4udrA:
undetectable
3m0wG-4udrA:
undetectable
3m0wH-4udrA:
undetectable		 3m0wE-4udrA:
10.66
3m0wF-4udrA:
10.66
3m0wG-4udrA:
10.66
3m0wH-4udrA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 7 SER A 308
VAL A 465
TRP A 369
GLU A 306
 None
 1.16A 3n5tA-4udrA:
undetectable
3n5tB-4udrA:
undetectable		 3n5tA-4udrA:
24.04
3n5tB-4udrA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 7 GLU A 306
SER A 308
VAL A 465
TRP A 369
 None
 1.24A 3n61A-4udrA:
undetectable
3n61B-4udrA:
undetectable		 3n61A-4udrA:
22.40
3n61B-4udrA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 7 GLU A 306
SER A 308
VAL A 465
VAL A 370
 None
 1.29A 3n61A-4udrA:
undetectable
3n61B-4udrA:
undetectable		 3n61A-4udrA:
22.40
3n61B-4udrA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 10 LEU A 275
GLY A 267
ALA A 266
ILE A 263
ILE A 274
 None
FAD  A 700 (-3.7A)
FAD  A 700 (-3.6A)
None
None
 1.10A 3nu6B-4udrA:
undetectable		 3nu6B-4udrA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 12 ILE A 527
VAL A 493
ILE A 280
ILE A 263
ALA A 487
 None
 1.22A 3ohtA-4udrA:
undetectable
3ohtB-4udrA:
undetectable		 3ohtA-4udrA:
22.26
3ohtB-4udrA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 12 GLY A 362
ALA A 314
ALA A 364
THR A 317
LEU A 316
 None
 1.03A 3p2kA-4udrA:
3.0		 3p2kA-4udrA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 8 GLU A 306
SER A 308
VAL A 370
TRP A 369
 None
 1.27A 3rqlA-4udrA:
undetectable
3rqlB-4udrA:
undetectable		 3rqlA-4udrA:
22.40
3rqlB-4udrA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		3 / 3 ASN A 188
ALA A 199
ARG A 159
 None
 0.72A 3tj7C-4udrA:
undetectable
3tj7D-4udrA:
undetectable		 3tj7C-4udrA:
16.67
3tj7D-4udrA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 12 GLY A 267
ALA A 266
ILE A  35
ILE A 263
ILE A 274
 FAD  A 700 (-3.7A)
FAD  A 700 (-3.6A)
None
None
None
 1.01A 3tkgC-4udrA:
undetectable		 3tkgC-4udrA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 5 ASP A 140
GLY A 158
TYR A 143
ASP A 186
 None
 1.20A 3w9tA-4udrA:
undetectable		 3w9tA-4udrA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 5 ASP A 140
GLY A 158
TYR A 143
ASP A 186
 None
 1.19A 3w9tB-4udrA:
undetectable		 3w9tB-4udrA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 5 ASP A 140
GLY A 158
TYR A 143
ASP A 186
 None
 1.20A 3w9tF-4udrA:
undetectable		 3w9tF-4udrA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 9 THR A 278
LEU A 237
GLY A 245
VAL A 233
VAL A 248
 None
None
None
FAD  A 700 (-4.0A)
None
 1.08A 4c9pA-4udrA:
undetectable		 4c9pA-4udrA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 8 GLU A 306
SER A 308
VAL A 370
TRP A 369
 None
 1.35A 4d32A-4udrA:
undetectable
4d32B-4udrA:
undetectable		 4d32A-4udrA:
22.40
4d32B-4udrA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 12 GLY A  12
GLY A  17
THR A 265
LEU A 264
VAL A 233
 FAD  A 700 (-3.2A)
None
None
None
FAD  A 700 (-4.0A)
 1.21A 4f84A-4udrA:
2.2		 4f84A-4udrA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 8 ILE A  50
GLY A  14
ASN A 513
GLU A  36
 None
FAD  A 700 (-3.2A)
FAD  A 700 (-4.0A)
FAD  A 700 (-2.7A)
 0.95A 4fgjA-4udrA:
2.3
4fgjB-4udrA:
undetectable		 4fgjA-4udrA:
18.63
4fgjB-4udrA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 5 GLY A  97
GLY A  98
ASN A 102
GLU A  36
 FAD  A 700 (-3.2A)
FAD  A 700 (-3.1A)
FAD  A 700 (-4.1A)
FAD  A 700 (-2.7A)
 1.30A 4fglC-4udrA:
2.3		 4fglC-4udrA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 5 GLY A  97
GLY A  98
ASN A 513
GLU A  36
 FAD  A 700 (-3.2A)
FAD  A 700 (-3.1A)
FAD  A 700 (-4.0A)
FAD  A 700 (-2.7A)
 1.16A 4fglC-4udrA:
2.3		 4fglC-4udrA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 11 ILE A 355
ILE A 337
LEU A 412
ALA A 179
ALA A 178
 None
 1.06A 4h1nA-4udrA:
undetectable		 4h1nA-4udrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 12 GLY A  12
GLY A  13
GLY A  17
LEU A 264
VAL A 246
 FAD  A 700 (-3.2A)
FAD  A 700 ( 4.8A)
None
None
None
 0.90A 4htfA-4udrA:
undetectable		 4htfA-4udrA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 12 GLY A  12
GLY A  13
GLY A  17
LEU A 264
VAL A 246
 FAD  A 700 (-3.2A)
FAD  A 700 ( 4.8A)
None
None
None
 0.93A 4htfB-4udrA:
undetectable		 4htfB-4udrA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 7 ASN A 395
ALA A  77
VAL A 462
ARG A 459
 None
 0.88A 4ijiH-4udrA:
undetectable		 4ijiH-4udrA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 7 GLU A 306
SER A 308
VAL A 465
TRP A 369
 None
 1.18A 4k5jA-4udrA:
undetectable
4k5jB-4udrA:
undetectable		 4k5jA-4udrA:
23.94
4k5jB-4udrA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 12 ILE A 263
GLY A  14
GLY A  12
ALA A  21
ALA A 210
 None
FAD  A 700 (-3.2A)
FAD  A 700 (-3.2A)
None
None
 1.10A 4kicB-4udrA:
2.4		 4kicB-4udrA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 12 PRO A 373
ALA A 339
ALA A 408
GLY A 409
LEU A 412
 None
 0.89A 4oaeA-4udrA:
1.5		 4oaeA-4udrA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 9 ALA A 524
ALA A 520
LEU A 517
SER A  25
LEU A  24
 None
 1.24A 4or0A-4udrA:
undetectable		 4or0A-4udrA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 11 ARG A  23
SER A  25
SER A 218
ASP A 216
LEU A 225
 None
 1.48A 4or0A-4udrA:
undetectable		 4or0A-4udrA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 8 THR A  41
THR A 229
GLY A  96
GLY A  97
 None
None
None
FAD  A 700 (-3.2A)
 0.75A 4qvvK-4udrA:
undetectable
4qvvL-4udrA:
undetectable		 4qvvK-4udrA:
18.79
4qvvL-4udrA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 8 THR A  41
THR A 229
GLY A  96
GLY A  97
 None
None
None
FAD  A 700 (-3.2A)
 0.75A 4qvvY-4udrA:
undetectable
4qvvZ-4udrA:
undetectable		 4qvvY-4udrA:
18.79
4qvvZ-4udrA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 7 GLU A 306
ARG A  60
TYR A  89
GLY A 464
 None
 0.87A 4rdxA-4udrA:
undetectable		 4rdxA-4udrA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 12 HIS A 307
ALA A 467
SER A 469
GLY A 109
PRO A 373
 None
 1.02A 4uilH-4udrA:
undetectable
4uilL-4udrA:
undetectable		 4uilH-4udrA:
18.44
4uilL-4udrA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 6 ASP A  40
GLU A  36
ILE A 155
PRO A  47
 None
FAD  A 700 (-2.7A)
None
None
 1.01A 4xi3C-4udrA:
undetectable		 4xi3C-4udrA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 6 LEU A 215
GLU A  36
ILE A 155
PRO A  47
 None
FAD  A 700 (-2.7A)
None
None
 1.10A 4xi3C-4udrA:
undetectable		 4xi3C-4udrA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 7 ASP A 500
ILE A 503
GLY A 488
THR A 265
 FAD  A 700 (-4.3A)
None
None
None
 1.11A 4zxiA-4udrA:
undetectable		 4zxiA-4udrA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 7 GLU A 306
SER A 308
VAL A 465
TRP A 369
 None
 1.21A 5adlA-4udrA:
undetectable
5adlB-4udrA:
undetectable		 5adlA-4udrA:
23.94
5adlB-4udrA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 8 SER A  99
GLY A  96
ALA A 499
GLY A  17
 None
 0.84A 5albL-4udrA:
undetectable		 5albL-4udrA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 7 GLU A 306
SER A 308
VAL A 465
TRP A 369
 None
 1.21A 5fj3A-4udrA:
undetectable
5fj3B-4udrA:
undetectable		 5fj3A-4udrA:
23.94
5fj3B-4udrA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 7 GLY A 301
LYS A 380
ASP A 285
ASN A 303
 None
 1.01A 5mvsA-4udrA:
2.1		 5mvsA-4udrA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		3 / 3 THR A 509
HIS A 307
ASN A 511
 None
None
FAD  A 700 (-4.7A)
 0.78A 5n4tA-4udrA:
undetectable		 5n4tA-4udrA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 12 ALA A  16
GLY A  13
GLU A  36
GLY A  12
LEU A  71
 FAD  A 700 (-3.3A)
FAD  A 700 ( 4.8A)
FAD  A 700 (-2.7A)
FAD  A 700 (-3.2A)
None
 1.19A 5ul4A-4udrA:
2.4		 5ul4A-4udrA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 7 GLU A 306
SER A 308
VAL A 465
TRP A 369
 None
 1.20A 5vv7A-4udrA:
undetectable
5vv7B-4udrA:
undetectable		 5vv7A-4udrA:
23.94
5vv7B-4udrA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 7 GLU A 306
SER A 308
VAL A 465
TRP A 369
 None
 1.20A 5vvnA-4udrA:
undetectable
5vvnB-4udrA:
undetectable		 5vvnA-4udrA:
23.94
5vvnB-4udrA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		3 / 3 TYR A   8
LEU A  20
ASP A 500
 None
None
FAD  A 700 (-4.3A)
 0.76A 5zv2B-4udrA:
undetectable		 5zv2B-4udrA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 7 SER A 308
VAL A 465
TRP A 369
GLU A 306
 None
 1.22A 6av6A-4udrA:
undetectable
6av6B-4udrA:
undetectable		 6av6A-4udrA:
11.00
6av6B-4udrA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 7 GLU A 306
SER A 308
VAL A 465
TRP A 369
 None
 1.27A 6av6C-4udrA:
undetectable
6av6D-4udrA:
0.8		 6av6C-4udrA:
11.00
6av6D-4udrA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 7 SER A 308
VAL A 465
TRP A 369
GLU A 306
 None
 1.27A 6av7A-4udrA:
undetectable
6av7B-4udrA:
undetectable		 6av7A-4udrA:
11.00
6av7B-4udrA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		5 / 12 ILE A  46
THR A  41
VAL A 219
VAL A 221
SER A  18
 None
 1.14A 6bzoC-4udrA:
undetectable		 6bzoC-4udrA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE
(Methylovorus
sp.
MP688) 		4 / 6 THR A 347
ARG A 112
PRO A 373
ARG A 405
 None
 1.43A 6ef6A-4udrA:
undetectable		 6ef6A-4udrA:
21.74