SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4uds'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 4uds MBDR REGULATOR
(Azoarcus
sp.
CIB) 		3 / 3 ALA A 172
HIS A 173
VAL A 176
 None
 0.41A 1lqtB-4udsA:
undetectable		 1lqtB-4udsA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 4uds MBDR REGULATOR
(Azoarcus
sp.
CIB) 		3 / 3 ALA A 172
HIS A 173
VAL A 176
 None
 0.42A 1lquB-4udsA:
undetectable		 1lquB-4udsA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 4uds MBDR REGULATOR
(Azoarcus
sp.
CIB) 		5 / 12 GLY A  46
ILE A  52
ALA A  42
TYR A  55
SER A  16
 None
 1.17A 1ri4A-4udsA:
undetectable		 1ri4A-4udsA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 4uds MBDR REGULATOR
(Azoarcus
sp.
CIB) 		4 / 5 ASP A  26
LEU A  27
MET A  40
ARG A  44
 None
 1.27A 2gj5A-4udsA:
undetectable		 2gj5A-4udsA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 4uds MBDR REGULATOR
(Azoarcus
sp.
CIB) 		5 / 9 ILE A  41
ILE A  38
PHE A  28
THR A  58
ALA A  61
 None
 1.17A 2m9qA-4udsA:
undetectable		 2m9qA-4udsA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 4uds MBDR REGULATOR
(Azoarcus
sp.
CIB) 		3 / 3 PRO A 108
GLU A 179
TYR A 181
 None
 0.81A 2zmbA-4udsA:
undetectable		 2zmbA-4udsA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4uds MBDR REGULATOR
(Azoarcus
sp.
CIB) 		5 / 12 LEU A 146
ALA A 148
GLY A 141
SER A 162
LEU A 165
 None
 1.07A 3gyqA-4udsA:
undetectable
3gyqB-4udsA:
undetectable		 3gyqA-4udsA:
22.74
3gyqB-4udsA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 4uds MBDR REGULATOR
(Azoarcus
sp.
CIB) 		4 / 6 LEU A  67
GLU A  69
ILE A 115
PRO A  77
 None
 0.82A 4xi3C-4udsA:
undetectable		 4xi3C-4udsA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4uds MBDR REGULATOR
(Azoarcus
sp.
CIB) 		6 / 12 ILE A 135
VAL A 111
HIS A 110
GLY A  32
THR A  36
TYR A  33
 None
 1.26A 5igtA-4udsA:
undetectable		 5igtA-4udsA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4uds MBDR REGULATOR
(Azoarcus
sp.
CIB) 		3 / 3 TYR A  81
HIS A 142
MET A 139
 None
 1.03A 6af6A-4udsA:
undetectable		 6af6A-4udsA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4uds MBDR REGULATOR
(Azoarcus
sp.
CIB) 		5 / 12 LEU A 113
VAL A 111
ARG A 138
ILE A  74
ASP A  76
 None
 1.24A 6bxmA-4udsA:
undetectable		 6bxmA-4udsA:
21.07